Nerve Growth Factor

Publication Title: 
Addiction Biology

We investigated the Cytosin-phosphatidyl-Guanin (CpG) island promoter methylation (mean and methylation of individual CpG-sites) of the nerve growth factor (NGF) gene in the blood of alcohol-dependent patients (57 male patients) during withdrawal (days 1, 7 and 14). Methylation and NGF serum levels did not change significantly from days 1-7. From days 7-14, mean methylation increased (F?=?30.55, P?<?0.001), whereas the NGF serum levels decreased significantly (days 7-14: F?=?17.95, P?<?0.001).

Heberlein, Annemarie
Muschler, Marc
Frieling, Helge
Behr, Michael
Eberlein, Christian
Wilhelm, Julia
Grˆschl, Michael
Kornhuber, Johannes
Bleich, Stefan
Hillemacher, Thomas
Publication Title: 

Our current knowledge of the neurobiology of romantic love remains scanty. In view of the complexity of a sentiment like love, it would not be surprising that a diversity of biochemical mechanisms could be involved in the mood changes of the initial stage of a romance. In the present study, we have examined whether the early romantic phase of a loving relationship could be associated with alterations in circulating levels of neurotrophins (NTs).

Emanuele, Enzo
Politi, Pierluigi
Bianchi, Marika
Minoretti, Piercarlo
Bertona, Marco
Geroldi, Diego
Publication Title: 
Archives Italiennes De Biologie

Romantic love is the catalyst behind the spread of the human life. The neurobiology of love embraces the hypothesis that what we call "romantic attachment" or "romantic love" may be at least in part the expression of biological factors. A corollary of this hypothesis states that it is possible to learn much about the nature of human love by studying the molecules involved in the expression of social and affiliative behaviours. Under this theoretical framework, we have investigated the changes in plasma neurotrophin levels in subjects with early stage romantic love.

Emanuele, Enzo
Publication Title: 
The Journal of Biological Chemistry

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that predisposes individuals to develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). Due to the lack of information on the molecular mechanism of NF1-associated tumor pathogenesis or biomarkers/therapeutic targets, an effective treatment for NF1 tumors has not been established.

Kobayashi, Daiki
Hirayama, Mio
Komohara, Yoshihiro
Mizuguchi, Souhei
Wilson Morifuji, Masayo
Ihn, Hironobu
Takeya, Motohiro
Kuramochi, Akira
Araki, Norie
Publication Title: 
Acta Medica Okayama

We studied the effects of natural essential oil on neurite outgrowth in PC12m3 neuronal cells to elucidate the mechanism underlying the action of the oils used in aromatherapy. Neurite outgrowth can be induced by nerve growth factor (NGF), where ERK and p38 MAPK among MAPK pathways play important roles in activating intracellular signal transduction. In this study, we investigated whether d-limonene, the major component of essential oils from oranges, can promote neurite outgrowth in PC12m3 cells, in which neurite outgrowth can be induced by various physical stimulations.

Shinomiya, Misae
Kawamura, Kenji
Tanida, Emiko
Nagoshi, Megumi
Motoda, Hirotoshi
Kasanami, Yoshiko
Hiragami, Fukumi
Kano, Yoshio
Publication Title: 
Journal of Ethnopharmacology

The effects of an ayurvedic compound (MAK-5) alone or together with nerve growth factor (NGF) on the neurite outgrowth of PC12 cells was studied. PC12 cells treated with NGF alone showed a clear neurite outgrowth with a decrease of the proliferation at the dose higher than 5 ng/ml. MAK-5 alone does not induce significant neurite outgrowth in the PC12 cells and does not decrease the proliferation.

Rodella, Luigi
Borsani, Elisa
Rezzani, Rita
Lanzi, Roberto
Lonati, Claudio
Bianchi, Rossella
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

Nerve growth factor (NGF) can induce apoptosis by signaling through the p75 neurotrophin receptor (p75(NTR)) in several nerve cell populations. Cultured embryonic motor neurons expressing p75(NTR) are not vulnerable to NGF unless they are exposed to an exogenous flux of nitric oxide (*NO). In the present study, we show that p75(NTR)-mediated apoptosis in motor neurons involved neutral sphingomyelinase activation, increased mitochondrial superoxide production, and cytochrome c release to the cytosol.

Pehar, Mariana
Vargas, Marcelo R.
Robinson, Kristine M.
Cassina, Patricia
Díaz-Amarilla, Pablo J.
Hagen, Tory M.
Radi, Rafael
Barbeito, Luis
Beckman, Joseph S.
Publication Title: 
Brain Research

Chronic morphine administration induces functional and morphological alterations in the mesolimbic dopamine system (MLDS), which is believed to be the neurobiological substrate of opiate addiction. Our previous studies have demonstrated that peripheral electrical stimulation (PES) can suppress morphine withdrawal syndrome and morphine-induced conditioned place preference (CPP) in rats. The present study was designed to investigate if PES could reverse the cell size reduction induced by chronic morphine treatment in the ventral tegmental area (VTA), which is an important area of the MLDS.

Chu, Ning-Ning
Zuo, Yan-Fang
Meng, Li
Lee, David Yue-Wei
Han, Ji-sheng
Cui, Cai-Lian
Publication Title: 
FEBS letters

The pharmacology and clinical application of traditional Chinese medicine has been extensively documented. We have used an in vitro model system, PC12 cells, to demonstrate the presence of neuroactive compounds in Ganoderma lucidum (lingzhi). Ganoderma extract induced the neuronal differentiation of PC12 cells and prevented nerve growth factor-dependent PC12 neurons from apoptosis.

Cheung, W. M.
Hui, W. S.
Chu, P. W.
Chiu, S. W.
Ip, N. Y.
Publication Title: 
Biological & Pharmaceutical Bulletin

Aster scaber T. (Asteraceae) has been used to treat bruises, snakebite, headache, and dizziness in traditional Chinese medicine. In the present study, the neuroprotective effect of four quinic acid derivatives from A. scaber on amyloid Abeta-induced PC12 cell toxicity was investigated. When cells were treated with quinic acid derivatives prior to Abeta, cell toxicity was significantly diminished. Among quinic acid derivatives, (-)4,5-dicaffeoyl quinic acid (1) gave the highest protection against Abeta-induced cell toxicity.

Hur, J. Y.
Soh, Y.
Kim, B. H.
Suk, K.
Sohn, N. W.
Kim, H. C.
Kwon, H. C.
Lee, K. R.
Kim, S. Y.


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