Nerve Regeneration

Publication Title: 
Neural Regeneration Research

OBJECTIVE: To evaluate the effectiveness and safety of the Xingnao Kaiqiao needling method for treating acute ischemic stroke. DATA SOURCES: We retrieved relevant randomized controlled trials involving Xingnao Kaiqiao acupuncture for treatment of acute ischemic stroke. The China National Knowledge Infrastructure, Weipu Information Resources System, Wanfang Medical Data System, Chinese Biomedical Literature Database, Cochrane Library, and PubMed were searched from June 2006 to March 2016.

Author(s): 
Yang, Zhi-Xin
Xie, Jia-Hong
Liu, Ding-Ding
Publication Title: 
Neural Regeneration Research

OBJECTIVE: To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL: We retrieved data from the Chinese National Knowledge Infrastructure (1979-2012), Wanfang (1980-2012), VIP (1989-2012), Chinese Biomedical Literature (1975-2012), PubMed (1966-2012), Ovid Lww (-2012), and Cochrane Library (-2012) Database using the internet.

Author(s): 
Zhang, Jiping
Chen, Jing
Chen, Junqi
Li, Xiaohui
Lai, Xueyan
Zhang, Shaoqun
Wang, Shengxu
Publication Title: 
Neural Regeneration Research

OBJECTIVE: To systematically evaluate the long-term effect and safety of Xingnao Kaiqiao needling method in ischemic stroke treatment. DATA RETRIEVAL: We retrieved relevant random and semi-random controlled trials that used the Xingnao Kaiqiao needling method to treat ischemic stroke compared with various control treatments such as conventional drugs or other acupuncture therapies.

Author(s): 
Yang, Zhi-Xin
Xie, Jia-Hong
Liu, Yong-Ping
Miao, Guang-Xin
Wang, Ying-Han
Wu, Sheng-Mei
Li, Yuan
Publication Title: 
Neural Regeneration Research

OBJECTIVE: To assess the efficacy of acupuncture combined with vitamin B12 acupoint injection versus acupuncture alone to reduce incomplete recovery in patients with Bell's palsy. DATA RETRIEVAL: A computer-based online retrieval of Medline, Web of Science, CNKI, CBM databases until April 2014 was performed for relevant trials, using the key words "Bell's palsy or idiopathic facial palsy or facial palsy" and "acupuncture or vitamin B12 or methylcobalamin".

Author(s): 
Wang, Li-Li
Guan, Ling
Hao, Peng-Liang
Du, Jin-Long
Zhang, Meng-Xue
Publication Title: 
The Journal of Pharmacy and Pharmacology

Axonal regeneration is important for functional recovery following nerve damage. Centella asiatica Urban herb, also known as Hydrocotyle asiatica L., has been used in Ayurvedic medicine for centuries as a nerve tonic. Here, we show that Centella asiatica ethanolic extract (100 microg mL-1) elicits a marked increase in neurite outgrowth in human SH-SY5Y cells in the presence of nerve growth factor (NGF). However, a water extract of Centella was ineffective at 100 microg mL-1.

Author(s): 
Soumyanath, Amala
Zhong, Yong-Ping
Gold, Sandra A.
Yu, XiaoLin
Koop, Dennis R.
Bourdette, Dennis
Gold, Bruce G.
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

An ideal therapeutic for stroke or spinal cord injury should promote survival and regeneration in the CNS. Arginase 1 (Arg1) has been shown to protect motor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins. To identify small molecules that capture Arg1's protective and regenerative properties, we screened a hippocampal cell line stably expressing the proximal promoter region of the arginase 1 gene fused to a reporter gene against a library of compounds containing clinically approved drugs.

Author(s): 
Ma, Thong C.
Campana, Aline
Lange, Philipp S.
Lee, Hsin-Hwa
Banerjee, Kasturi
Bryson, J. Barney
Mahishi, Lata
Alam, Shabnam
Giger, Roman J.
Barnes, Stephen
Morris, Sidney M.
Willis, Dianna E.
Twiss, Jeffrey L.
Filbin, Marie T.
Ratan, Rajiv R.
Publication Title: 
Annals of Anatomy = Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft

Insufficient recovery after peripheral nerve injury has been attributed to (i) poor pathfinding of regrowing axons, (ii) excessive collateral axonal branching at the lesion site and (iii) polyneuronal innervation of the neuromuscular junctions (NMJ). The facial nerve transection model has been used initially to measure restoration of function after varying therapies and to examine the mechanisms underlying their effects. Since it is very difficult to control the navigation of several thousand axons, efforts concentrated on collateral branching and NMJ-polyinnervation.

Author(s): 
Skouras, Emmanouil
Ozsoy, Umut
Sarikcioglu, Levent
Angelov, Doychin N.
Publication Title: 
The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques

BACKGROUND AND PURPOSE: Sildenafil citrate has been shown to enhance neurogenesis, angiogenesis, synaptogenesis, and neurological outcome by augmentation of cyclic guanosine monophosphate (cGMP) levels in animal models of ischemic stroke. Whether sildenafil citrate may be helpful for recovery in human stroke is unknown at this time. METHODS: A 41-year-old woman with locked-in syndrome due to pontine infarction began receiving 150 mg of oral sildenafil citrate daily on a compassionate use basis in August 2003 and continues treatment at this time.

Author(s): 
Silver, Brian
Grover, Kavita M.
Arcila, Ximena
Mitsias, Panayiotis D.
Bowyer, Susan M.
Chopp, Michael
Publication Title: 
Lasers in Surgery and Medicine

BACKGROUND AND OBJECTIVE: Low level light (or laser) therapy (LLLT) is a rapidly growing modality used in physical therapy, chiropractic, sports medicine and increasingly in mainstream medicine. LLLT is used to increase wound healing and tissue regeneration, to relieve pain and inflammation, to prevent tissue death, to mitigate degeneration in many neurological indications.

Author(s): 
Hashmi, Javad T.
Huang, Ying-Ying
Sharma, Sulbha K.
Kurup, Divya Balachandran
De Taboada, Luis
Carroll, James D.
Hamblin, Michael R.
Publication Title: 
Journal of Pharmacological Sciences

Shengmai-san (SMS) is a traditional Chinese medicine used to treat diverse symptoms including cardiovascular and neurological disorders. Here we investigated the effects of SMS on regenerative responses of spinal cord axons in rats that were given contusion injury at the lower thoracic level. The injury cavity was confined to a restricted area by SMS treatment, and the signals of glial scar protein chondroitin sulphate proteoglycan (CSPG) and inflammatory cell marker protein CD11beta were heavily observed within the injury cavity in SMS-treated animals.

Author(s): 
Seo, Tae Beom
Baek, Kyungmin
Kwon, Ku-Birm
Lee, Sang-Ik
Lim, Jong-Soon
Seol, In Chan
Kim, Yoon Sik
Seo, Young-Bae
Namgung, Uk

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