Publication Title: 
Experimental Neurology

Among several genetic mutations known to cause amyotrophic lateral sclerosis (ALS), a hexanucleotide repeat expansion in the C9orf72 gene is the most common. In approximately 30% of C9orf72-ALS cases, 5-methylcytosine (5mC) levels within the C9orf72 promoter are increased, resulting in a modestly attenuated phenotype. The developmental timing of C9orf72 promoter hypermethylation and the reason why it occurs in only a subset of patients remain unknown.

Esanov, Rustam
Belle, Kinsley C.
van Blitterswijk, Marka
Belzil, Veronique V.
Rademakers, Rosa
Dickson, Dennis W.
Petrucelli, Leonard
Boylan, Kevin B.
Dykxhoorn, Derek M.
Wuu, Joanne
Benatar, Michael
Wahlestedt, Claes
Zeier, Zane
Publication Title: 
Stem Cells (Dayton, Ohio)

Mesenchymal stem cells (MSCs) exhibit immune-suppressive properties, follow a pattern of multilineage differentiation, and exhibit transdifferentiation potential. Ease in expansion from adult bone marrow, as well as its separation from ethical issues, makes MSCs appealing for clinical application. MSCs treated with retinoic acid resulted in synaptic transmission, based on immunostaining of synaptophysin and electrophysiological studies. In situ hybridization indicated that the neurotransmitter gene preprotachykinin-I was expressed in these cells.

Cho, Kyung Jin
Trzaska, Katarzyna A.
Greco, Steven J.
McArdle, Joseph
Wang, Fu Shun
Ye, Jiang-Hong
Rameshwar, Pranela
Publication Title: 
FASEB journal: official publication of the Federation of American Societies for Experimental Biology

The presence of pericytes in brain regions undergoing repair is evident of the recruitment of bone marrow-derived multipotent regenerative cells to the neurovascular unit during angiogenesis. At present, post mortem sampling is the only way to identify them. Therefore, such cell typing is inadequate for preserving neural progenitor cells for any meaningful stem cell therapy. We aimed to target cerebral pericytes in vivo using dual gene transcript-targeted MRI (GT-tMRI) in male C57black6 mice after a 60-min bilateral carotid artery occlusion (BCAO).

Liu, Christina H.
Ren, Jia Q.
You, Zerong
Yang, Jinsheng
Liu, Charng-Ming
Uppal, Ritika
Liu, Philip K.
Publication Title: 
PloS One

Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia, followed by sight threatening pathologic neovascularization in the second phase. Previously we found that Sirtuin1 (Sirt1), a metabolically dependent protein deacetylase, regulates vascular regeneration in a mouse model of oxygen-induced proliferative retinopathy (OIR), as neuronal depletion of Sirt1 in retina worsens retinopathy.

Michan, Shaday
Juan, Aimee M.
Hurst, Christian G.
Cui, Zhenghao
Evans, Lucy P.
Hatton, Colman J.
Pei, Dorothy T.
Ju, Meihua
Sinclair, David A.
Smith, Lois E. H.
Chen, Jing
Publication Title: 
Journal of Child Neurology

Gliomatosis confined to the cerebellum is most unusual. We report such a case in a 20-month-old male who presented with unsteadiness. Magnetic resonance imaging revealed a diffuse area of abnormal signal intensity within both cerebellar hemispheres, which did not enhance after contrast administration. The patient underwent a biopsy, which revealed a diffuse glioma infiltrating the cerebellum. Overall, the tumor cells had oligodendroglioma-like features and exhibited only focal vimentin immunoreactivity.

Chadarévian, Jean-Pierre de
Legido, Agustin
Halligan, Gregory E.
Faerber, Eric N.
Piatt, Joseph H.
Morrissette, Jennifer D.
Ara, Jahan
Grant, Mitzie L.
Katsetos, Christos D.
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