Neuropeptide Y

Publication Title: 
Molecular and Cellular Endocrinology

Laboratory studies consistently demonstrate extended lifespan in animals on calorie restriction (CR), where total caloric intake is reduced by 10-40% but adequate nutrition is otherwise maintained. CR has been further shown to delay the onset and severity of chronic diseases associated with aging such as cancer, and to extend the functional health span of important faculties like cognition. Less understood are the underlying mechanisms through which CR might act to induce such alterations.

Author(s): 
Minor, Robin K.
Chang, Joy W.
de Cabo, Rafael
Publication Title: 
Experimental Biology and Medicine (Maywood, N.J.)

Aging degrades motivation, cognition, sensory modalities and physical capacities, essentially dimming zestful living. Bradykinesis (declining physical movement) is a highly reliable biomarker of aging and mortality risk. Mice fed a complex dietary supplement (DSP) designed to ameliorate five mechanisms associated with aging showed no loss of total daily locomotion compared with >50% decrement in old untreated mice.

Author(s): 
Aksenov, Vadim
Long, Jiangang
Lokuge, Sonali
Foster, Jane A.
Liu, Jiankang
Rollo, C. David
Publication Title: 
Science (New York, N.Y.)
Author(s): 
Marx, Jean
Publication Title: 
Molecular and Cellular Endocrinology

Laboratory studies consistently demonstrate extended lifespan in animals on calorie restriction (CR), where total caloric intake is reduced by 10-40% but adequate nutrition is otherwise maintained. CR has been further shown to delay the onset and severity of chronic diseases associated with aging such as cancer, and to extend the functional health span of important faculties like cognition. Less understood are the underlying mechanisms through which CR might act to induce such alterations.

Author(s): 
Minor, Robin K.
Chang, Joy W.
de Cabo, Rafael
Publication Title: 
Cellular and molecular life sciences: CMLS

Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of alcoholism.

Author(s): 
Moonat, Sachin
Starkman, Bela G.
Sakharkar, Amul
Pandey, Subhash C.
Publication Title: 
The American Journal of Psychiatry

OBJECTIVE: Most research on the effects of severe psychological stress has focused on stress-related psychopathology. Here, the author develops psychobiological models of resilience to extreme stress. METHOD: An integrative model of resilience and vulnerability that encompasses the neurochemical response patterns to acute stress and the neural mechanisms mediating reward, fear conditioning and extinction, and social behavior is proposed.

Author(s): 
Charney, Dennis S.
Publication Title: 
British Journal of Pharmacology

Despite the generally held view that alcohol is an unspecific pharmacological agent, recent molecular pharmacology studies demonstrated that alcohol has only a few known primary targets. These are the NMDA, GABA(A), glycine, 5-hydroxytryptamine 3 (serotonin) and nicotinic ACh receptors as well as L-type Ca(2+) channels and G-protein-activated inwardly rectifying K(+) channels.

Author(s): 
Vengeliene, V.
Bilbao, A.
Molander, A.
Spanagel, R.
Publication Title: 
PloS One

Nutritional infertility is very common in societies where women fail to eat enough to match their energy expenditure and such females often present as clinical cases of anorexia nervosa. The cellular and molecular mechanisms that link energy balance and central regulation of reproduction are still not well understood.

Author(s): 
Kumar, Sushil
Kaur, Gurcharan
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Previous studies have demonstrated that some endocrine consequences of long-term caloric restriction persist after weight restoration in human subjects. Here we evaluate effects of chronic food restriction in rats that were restricted to 70% of control kcal for 4 wk and subsequently weight restored. Measures were taken from rats at 80% (chronically restricted; CR), 90% (partially weight restored; PR), 100% (fully weight restored; FR), and after 4 wk at 100% body weight of controls (extended weight restored; ER).

Author(s): 
Kinzig, Kimberly P.
Hargrave, Sara L.
Tao, Erin E.
Publication Title: 
Molecular and Cellular Endocrinology

Laboratory studies consistently demonstrate extended lifespan in animals on calorie restriction (CR), where total caloric intake is reduced by 10-40% but adequate nutrition is otherwise maintained. CR has been further shown to delay the onset and severity of chronic diseases associated with aging such as cancer, and to extend the functional health span of important faculties like cognition. Less understood are the underlying mechanisms through which CR might act to induce such alterations.

Author(s): 
Minor, Robin K.
Chang, Joy W.
de Cabo, Rafael

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