Neuropsychological Tests

Publication Title: 
Clinical Psychology Review

Mindfulness meditation practices (MMPs) are a subgroup of meditation practices which are receiving growing attention. The present paper reviews current evidence about the effects of MMPs on objective measures of cognitive functions. Five databases were searched. Twenty three studies providing measures of attention, memory, executive functions and further miscellaneous measures of cognition were included. Fifteen were controlled or randomized controlled studies and 8 were case-control studies.

Author(s): 
Chiesa, Alberto
Calati, Raffaella
Serretti, Alessandro
Publication Title: 
Journal of Neurology

BACKGROUND: Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be safe and to have beneficial effects on cognition, function, behavior, and global patient status in patients with Alzheimer's disease (AD) in studies lasting 3-6 months. It is approved in the U.S. and Europe for the treatment of moderate to severe AD and is currently under investigation for mild to moderate AD. OBJECTIVE: To evaluate the long-term safety of memantine in patients with mild to moderate AD and to investigate the tolerability of once-daily dose administration.

Author(s): 
Ott, Brian R.
Blake, Lesley M.
Kagan, Ethel
Resnick, Malca
Memantine MEM-MD-11AB Study Group
Publication Title: 
Depression and Anxiety

BACKGROUND: Scant research has examined the effect of neuropsychological (NP) functioning on treatment outcome in pediatric obsessive-compulsive disorder (OCD). This study sought to address this gap in existing research. METHODS: A total of 63 youths were included in this study and asked to complete the Rey-Osterrieth Complex Figure (ROCF) and specific subtests of the Wechsler Intelligence Scale for Children, Third Edition (WISC-III).

Author(s): 
Flessner, Christopher A.
Allgair, Amy
Garcia, Abbe
Freeman, Jennifer
Sapyta, Jeffrey
Franklin, Martin E.
Foa, Edna
March, John
Publication Title: 
The British Journal of Psychiatry: The Journal of Mental Science

BACKGROUND: The mental status examination of an extreme case of longevity, J. C., aged 118 years and 9 months, is documented in order to further knowledge regarding profiles of morbidity in the extremely elderly. J. C. is presently considered to have the longest authenticated life-span in the history of the human species. METHOD: Neuropsychological tests were improvised taking into account the subject's severe perceptual deficits. The examination was carried out over a six-month period. A CT scan was also conducted.

Author(s): 
Ritchie, K.
Publication Title: 
Neurology

OBJECTIVE: To examine the relative risk and population attributable risk (PAR) of death with dementia of varying type and severity and other risk factors in a population of exceptional longevity. METHODS: Deaths were monitored over 5 years using vital statistics records and newspaper obituaries in 355 individuals with prevalent dementia and 4,328 without in Cache County, UT. Mean age was 83.3 (SD 7.0) years with dementia and 73.7 (SD 6.8) years without. History of coronary artery disease, hypertension, diabetes, and other life-shortening illness was ascertained from interviews.

Author(s): 
Tschanz, J. T.
Corcoran, C.
Skoog, I.
Khachaturian, A. S.
Herrick, J.
Hayden, K. M.
Welsh-Bohmer, K. A.
Calvert, T.
Norton, M. C.
Zandi, P.
Breitner, J. C. S.
Cache County Study Group
Publication Title: 
Neuroscience Letters

A cholesteryl ester transfer protein (CETP) genotype (V/V homozygosity for I405V, NCBI dbSNP rs5882) has been associated with preservation of cognitive function in old age, in addition to its associations with exceptional longevity and cardiovascular disease. We tested the hypotheses that this polymorphism was associated with either level of cognitive function or lifetime cognitive change in 525 participants who took part in the Scottish Mental Survey of 1932. Participants took the same well-validated mental ability test at ages 11 and 79.

Author(s): 
Johnson, Wendy
Harris, Sarah E.
Collins, Patrick
Starr, John M.
Whalley, Lawrence J.
Deary, Ian J.
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS). DESIGN: Community-based prospective cohort study. SETTING: Bronx, New York. PARTICIPANTS: A volunteer sample of 424 community-residing older adults without dementia aged 75 to 85 recruited from Bronx County starting in 1980 and followed for up to 23 years. MEASUREMENTS: Epidemiological, clinical, and neuropsychological assessments were completed every 12 to 18 months.

Author(s): 
Lipton, Richard B.
Hirsch, Jamie
Katz, Mindy J.
Wang, Cuiling
Sanders, Amy E.
Verghese, Joe
Barzilai, Nir
Derby, Carol A.
Publication Title: 
Neurobiology of Aging

The authors investigated whether cognitive function may be used as an endophenotype for longevity by assessing the cognitive performance of a family-based cohort consisting of 1380 individuals from 283 families recruited for exceptional survival in field centers in Boston, New York, Pittsburgh, and Denmark. Cognitive performance was assessed in the combined offspring of the Long Life Family Study (LLFS) probands and their LLFS siblings as compared with their spouses' cognitive performance.

Author(s): 
Barral, Sandra
Cosentino, Stephanie
Costa, Rosann
Matteini, Amy
Christensen, Kaare
Andersen, Stacy L.
Glynn, Nancy W.
Newman, Anne B.
Mayeux, Richard
Publication Title: 
Molecular Psychiatry

General intelligence is a robust predictor of important life outcomes, including educational and occupational attainment, successfully managing everyday life situations, good health and longevity. Some neuronal correlates of intelligence have been discovered, mainly indicating that larger cortices in widespread parieto-frontal brain networks and efficient neuronal information processing support higher intelligence. However, there is a lack of established associations between general intelligence and any basic structural brain parameters that have a clear functional meaning.

Author(s): 
Penke, L.
Maniega, S. MuÒoz
Bastin, M. E.
ValdÈs Hern·ndez, M. C.
Murray, C.
Royle, N. A.
Starr, J. M.
Wardlaw, J. M.
Deary, I. J.
Publication Title: 
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

OBJECTIVE: The objective of this study was to determine the effects of a 14-day healthy longevity lifestyle program on cognition and cerebral metabolism in people with mild age-related memory complaints.

Author(s): 
Small, Gary W.
Silverman, Daniel H. S.
Siddarth, Prabha
Ercoli, Linda M.
Miller, Karen J.
Lavretsky, Helen
Wright, Benjamin C.
Bookheimer, Susan Y.
Barrio, Jorge R.
Phelps, Michael E.

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