Neurotransmitter Uptake Inhibitors

Publication Title: 
The Psychiatric Clinics of North America

In summary, depressed patients with a history of childhood trauma may have a distinct depression endophenotype characterized by a specific neurobiology and risk genotype that may be responsive to different treatment strategies than depressed patients without childhood adversity. Based on current findings, treatment strategies should be multimodal and include the following: 1.

Saveanu, Radu V.
Nemeroff, Charles B.
Publication Title: 
Acta Biochimica Et Biophysica Hungarica

The effects of chronic administration of the calcium channel antagonist verapamil on the anesthetic effects of a novel specific alpha 2-receptor agonist (dexmedetomidine) were studied in rats. It is presumed that this agonist acts on both pre- and postsynaptic alpha 2-adrenoceptors. To determine whether the central postsynaptic receptors are involved in the anesthetic interactions between these drugs, rats were treated with DSP-4 to deplete endogenous norepinephrine. Loss of the righting reflex was used to determine the presence of anesthesia and the duration of hypnosis.

Horvàth, G.
Kovacs, M.
Szikszay, M.
Benedek, G.
Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

The effects of 1-[2-[bis (4-fluorophenyl)methoxy]ethyl]-4-(3- phenylpropyl) piperazine dihydrochloride (I-893) on the central nervous system were behaviorally and electroencephalographically investigated. Intraperitoneally injected I-893 (5-10 mg/kg) dose-dependently increased spontaneous motor activity in mice, but repeated injections did not affect the increase in the locomotor activity. In reserpinized mice, spontaneous motor activity was not increased by oral I-893.

Nagase, T.
Hotta, K.
Morita, S.
Sakai, K.
Yamane, M.
Omote, M.
Mizusawa, H.
Publication Title: 
Anesthesia and Analgesia

BACKGROUND: In clinical anesthesia, robust surgical stress occasionally causes unintended light anesthesia during operation. To test the hypothesis that neural input condition could modify actions of general anesthetics as a result of presynaptic alteration in the central nervous system, we investigated the mechanisms by which the stimulus frequency modifies synaptic transmission of the rat hippocampus in the presence of general anesthetics.

Hirota, Koki
Sasaki, Rika
Roth, Sheldon H.
Yamazaki, Mitsuaki
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