Nitrates

Publication Title: 
Nitric Oxide: Biology and Chemistry / Official Journal of the Nitric Oxide Society

BACKGROUND: Japanese longevity is the highest in the world. This is partly explained by low occurrence of cardiovascular diseases, which in turn is attributed to the Japanese traditional diet (JTD). Recent research demonstrates that nitric oxide (NO), a key regulator of vascular integrity, can be generated from nitrate (NO(3)(-)), abundantly found in vegetables. It can reduce blood pressure (BP) via its serial reduction to nitrite (NO(2)(-)) and to bioactive NO. Interestingly, JTD is extremely rich in nitrate and the daily consumption is higher than in any other known diet.

Author(s): 
Sobko, Tanja
Marcus, Claude
Govoni, Mirco
Kamiya, Shigeru
Publication Title: 
Journal of Neuro-Oncology

Regardless of their cell type of origin, all aggressive brain tumors, such as malignant gliomas and metastatic tumors produce brain edema, which is an important cause of patient morbidity and mortality. Caloric restriction (CR) has long been recognized as a natural therapy that improves health, promotes longevity, and significantly reduces both the incidence and growth of many tumor types. The aim of present work was to investigate the effect of CR on edema and survival in the mice implanted with U87 gliomas.

Author(s): 
Jiang, Yong-Sheng
Wang, Fu-Rong
Publication Title: 
Explore (New York, N.Y.)

BACKGROUND: Meditation is associated with lower blood pressure, but little is known about how loving-kindness meditation affects nitric oxide (NO) metabolism, a key mediator of cardiovascular physiology associated with vasodilation. METHODS: We studied seven inexperienced and five experienced healthy meditators at one study visit, after they refrained from eating nitrate-rich foods for at least 12h. Participants completed questionnaires on demographics and meditation practices.

Author(s): 
Kemper, Kathi J.
Powell, Daniel
Helms, Christine Carlisle
Kim-Shapiro, Daniel B.
Publication Title: 
Explore (New York, N.Y.)

BACKGROUND: Meditation is associated with lower blood pressure, but little is known about how loving-kindness meditation affects nitric oxide (NO) metabolism, a key mediator of cardiovascular physiology associated with vasodilation. METHODS: We studied seven inexperienced and five experienced healthy meditators at one study visit, after they refrained from eating nitrate-rich foods for at least 12h. Participants completed questionnaires on demographics and meditation practices.

Author(s): 
Kemper, Kathi J.
Powell, Daniel
Helms, Christine Carlisle
Kim-Shapiro, Daniel B.
Publication Title: 
BMJ case reports

A 40-year-old healthy manual labourer from a malaria endemic area with no known risk factors for atherosclerotic coronary vascular disease was admitted to our hospital with a history of fever with chills and rigours. Physical examination revealed tachypnoea and icterus. Peripheral smear showed trophozoites of Plasmodium vivax and thrombocytopaenia. The patient was administered artesunate. Six hours after admission, he complained of severe substernal chest pain. A 12-lead ECG revealed ST elevations in leads I, II and aVL.

Author(s): 
Bhat, Smitha
Alva, Jayaprakash
Muralidhara, Krithika
Fahad, Sayid
Publication Title: 
Cellular and Molecular Neurobiology

Methyl mercury (MeHg) is a ubiquitous environmental pollutant leading to neurological and developmental deficits in animals and human beings. Bacopa monniera (BM) is a perennial herb and is used as a nerve tonic in Ayurveda, a traditional medicine system in India. The objective of the present study was to investigate whether Bacopa monniera extract (BME) could potentially inhibit MeHg-induced toxicity in the cerebellum of rat brain. Male Wistar rats were administered with MeHg orally at a dose of 5 mg/kg b.w. for 21 days.

Author(s): 
Sumathi, Thangarajan
Shobana, Chandrasekar
Christinal, Johnson
Anusha, Chandran
Publication Title: 
Vascular Medicine (London, England)

We previously reported an attenuation of both exercise hyperemia and measures of aerobic capacity in hypercholesterolemic mice. In this study, we expanded upon the previous findings by examining the temporal and quantitative relationship of hypercholesterolemia to aerobic and anaerobic capacity and by exploring several potential mechanisms of dysfunction. Eight-week-old wild type (n = 123) and apoE knockout (n = 79) C57BL/6J mice were divided into groups with distinct cholesterol levels by feeding with regular or high-fat diets. At various ages, the mice underwent treadmill ergospirometry.

Author(s): 
Maxwell, Andrew J.
Niebauer, Josef
Lin, Patrick S.
Tsao, Philip S.
Bernstein, Daniel
Cooke, John P.
Publication Title: 
Obesity (Silver Spring, Md.)

The purposes of these studies were to quantify the concentrations of total nitrate and nitrite (NO(x)(-)) cyclic guanosine monophosphate (cGMP), and nitrotyrosine over skin surface in normal weight healthy volunteers (n = 64) compared to overweight/obese subjects (n = 54). A semi-circular plastic tube was taped to the skin along acupuncture points (acupoints), meridian line without acupoint (MWOP), and nonmeridian control and filled with a 2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl solution for 20 min.

Author(s): 
Ma, Sheng-Xing
Li, Xi-Yan
Smith, Brian T.
Jou, Nainn-Tsyr
Publication Title: 
PloS One

OBJECTIVE AND BACKGROUND: To assess renoprotective effects of a blueberry-enriched diet in a rat model of hypertension. Oxidative stress (OS) appears to be involved in the development of hypertension and related renal injury. Pharmacological antioxidants can attenuate hypertension and hypertension-induced renal injury; however, attention has shifted recently to the therapeutic potential of natural products as antioxidants. Blueberries (BB) have among the highest antioxidant capacities of fruits and vegetables.

Author(s): 
Elks, Carrie M.
Reed, Scott D.
Mariappan, Nithya
Shukitt-Hale, Barbara
Joseph, James A.
Ingram, Donald K.
Francis, Joseph
Publication Title: 
Experimental Neurology

The role of taurine in regulating glucose-induced nitrosative stress has been examined in human Schwann cells, a model for understanding the pathogenesis of diabetic neuropathy. Exposure to high glucose increased nitrated proteins (1.56 fold p<0.05), inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS) mRNA expression (1.55 fold and 2.2 fold respectively, p<0.05 both), phospho-p38 MAPK (1.32 fold, p<0.05) abundance and decreased Schwann cell growth (11±2%, p<0.05).

Author(s): 
Askwith, Trevor
Zeng, Wei
Eggo, Margaret C.
Stevens, Martin J.

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