Nitro Compounds

Publication Title: 
Zoology (Jena, Germany)

Currently, there is concern about declining bee populations and the sustainability of pollination services. One potential threat to bees is the unintended impact of systemic insecticides, which are ingested by bees in the nectar and pollen from flowers of treated crops. To establish whether imidacloprid, a systemic neonicotinoid and insect neurotoxin, harms individual bees when ingested at environmentally realistic levels, we exposed adult worker bumble bees, Bombus terrestris L. (Hymenoptera: Apidae), and honey bees, Apis mellifera L.

Author(s): 
Cresswell, James E.
Page, Christopher J.
Uygun, Mehmet B.
Holmbergh, Marie
Li, Yueru
Wheeler, Jonathan G.
Laycock, Ian
Pook, Christopher J.
de Ibarra, Natalie Hempel
Smirnoff, Nick
Tyler, Charles R.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Centella asiatica (CA) is a common medicinal plant used in the ayurvedic system of medicine to treat various ailments and as a memory enhancer. Despite its extensive usage in children, data on its ability to modulate neuronal oxidative stress in prepubertal rodents are limited.

Author(s): 
Shinomol, George K.
Muralidhara, null
Publication Title: 
Neurotoxicology

Despite the increasing popularity of Centella asiatica (a well known plant in ayurvedic medicine) globally, evidence demonstrating its protective efficacy against neurotoxicants in animal models is limited. 3-Nitropropionic acid (3-NPA), a fungal toxin is a well known neurotoxicant which induces selective striatal pathology similar to that seen in Huntington's disease. The present study aimed to understand the neuroprotective efficacy of a standardized aqueous extract of C.

Author(s): 
Shinomol, George K.
Muralidhara, null
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has emerged as the pathologic trigger, transcriptional dysfunction may contribute to the neurodegeneration observed in HD. Pharmacological treatment using the histone deacetylase inhibitor sodium butyrate to modulate transcription significantly extended survival in a dose-dependent manner, improved body weight and motor performance, and delayed the neuropathological sequelae in the R6/2 transgenic mouse model of HD.

Author(s): 
Ferrante, Robert J.
Kubilus, James K.
Lee, Junghee
Ryu, Hoon
Beesen, Ayshe
Zucker, Birgit
Smith, Karen
Kowall, Neil W.
Ratan, Rajiv R.
Luthi-Carter, Ruth
Hersch, Steven M.
Publication Title: 
Journal of Lipid Research

The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction. The formation of 9-NO2-octadeca-9,11-dienoic acid and 12-NO2-octadeca-9,11-dienoic acid stems from peroxynitrite- and myeloperoxidase-derived nitrogen dioxide reactions as well as secondary to nitrite disproportionation under the acidic conditions of digestion. Broad anti-inflammatory and tissue-protective responses are mediated by nitro-fatty acids.

Author(s): 
Salvatore, Sonia R.
Vitturi, Dario A.
Baker, Paul R. S.
Bonacci, Gustavo
Koenitzer, Jeffrey R.
Woodcock, Steven R.
Freeman, Bruce A.
Schopfer, Francisco J.
Publication Title: 
The Journal of Biological Chemistry

Inflammation, characterized by the activation of both resident and infiltrated immune cells, is accompanied by increased production of oxidizing and nitrating species. Nitrogen dioxide, the proximal nitrating species formed under these conditions, reacts with unsaturated fatty acids to yield nitroalkene derivatives. These electrophilic products modulate protein function via post-translational modification of susceptible nucleophilic amino acids.

Author(s): 
Vitturi, Dario A.
Chen, Chen-Shan
Woodcock, Steven R.
Salvatore, Sonia R.
Bonacci, Gustavo
Koenitzer, Jeffrey R.
Stewart, Nicolas A.
Wakabayashi, Nobunao
Kensler, Thomas W.
Freeman, Bruce A.
Schopfer, Francisco J.
Publication Title: 
The Journal of Organic Chemistry

Nitro-conjugated linoleic acids (NO2-cLA), endogenous nitrodiene lipids which act as inflammatory signaling mediators, were isolated and single isomers purified from the biomimetic acidic nitration products of conjugated linoleic acid (CLA). Structures were elucidated by means of detailed NMR and HPLC-MS/MS spectroscopic analysis and the relative double bond configurations assigned.

Author(s): 
Woodcock, Steven R.
Salvatore, Sonia R.
Bonacci, Gustavo
Schopfer, Francisco J.
Freeman, Bruce A.
Publication Title: 
PloS One

Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest salutary pleiotropic cell signaling responses in mammals. Herein, the endogenous presence of NO2-FA in both EVOO and fresh olives was demonstrated by mass spectrometry.

Author(s): 
Fazzari, Marco
Trostchansky, Andrés
Schopfer, Francisco J.
Salvatore, Sonia R.
Sánchez-Calvo, Beatriz
Vitturi, Dario
Valderrama, Raquel
Barroso, Juan B.
Radi, Rafael
Freeman, Bruce A.
Rubbo, Homero
Publication Title: 
Free Radical Biology & Medicine

Calorie restriction is a dietary intervention known to improve redox state, glucose tolerance, and animal life span. Other interventions have been adopted as study models for caloric restriction, including nonsupplemented food restriction and intermittent, every-other-day feedings. We compared the short- and long-term effects of these interventions to ad libitum protocols and found that, although all restricted diets decrease body weight, intermittent feeding did not decrease intra-abdominal adiposity.

Author(s): 
Cerqueira, Fernanda M.
da Cunha, Fernanda M.
Caldeira da Silva, Camille C.
Chausse, Bruno
Romano, Renato L.
Garcia, Camila C. M.
Colepicolo, Pio
Medeiros, Marisa H. G.
Kowaltowski, Alicia J.
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