Nitroanisole O-Demethylase

Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

The relationship between circadian rhythms in the pharmacological actions of meperidine and hexobarbital and similar rhythms in the hepatic metabolism of these drugs was examined in mice under a variety of environmental alterations to determine whether such rhythms may be causally related. The rate of metabolism of p-nitroanisole and hexobarbital by hepatic 9000 X g supernatant fractions was found to be higher at 2400 hours (middark phase) compared to 1200 hours (midlight phase).

Author(s): 
Holcslaw, T. L.
Miya, T. S.
Bousquet, W. S.
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