Nociception

Publication Title: 
Brain Sciences

OBJECTIVE: To assess the neural activity associated with mindfulness-based alterations of pain perception. METHODS: The Cochrane Central, EMBASE, Ovid Medline, PsycINFO, Scopus, and Web of Science databases were searched on 2 February 2016. Titles, abstracts, and full-text articles were independently screened by two reviewers. Data were independently extracted from records that included topics of functional neuroimaging, pain, and mindfulness interventions. RESULTS: The literature search produced 946 total records, of which five met the inclusion criteria.

Author(s): 
Bilevicius, Elena
Kolesar, Tiffany A.
Kornelsen, Jennifer
Publication Title: 
Physiological Measurement

During anaesthesia awareness and nociception are serious complications that may further lead to haemodynamic instability. Specific monitoring of depth of hypnosis and depth of analgesia based on heart rate variability (HRV) analysis is eligible to improve patient safety and reduce efforts in post-operative care. Consequently, in this analysis we assess the applicability of HRV parameters during surgical interventions with standardized intravenous propofol-remifentanil-anaesthesia.

Author(s): 
Huhle, R.
Burghardt, M.
Zaunseder, S.
Wessel, N.
Koch, T.
Malberg, H.
Heller, A. R.
Publication Title: 
Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology

OBJECTIVE: To (1) evaluate the effects of a single session of four non-pharmacological pain interventions, relative to a sham tDCS procedure, on pain and electroencephalogram- (EEG-) assessed brain oscillations, and (2) determine the extent to which procedure-related changes in pain intensity are associated with changes in brain oscillations.

Author(s): 
Jensen, Mark P.
Sherlin, Leslie H.
Askew, Robert L.
Fregni, Felipe
Witkop, Gregory
Gianas, Ann
Howe, Jon D.
Hakimian, Shahin
Publication Title: 
Best Practice & Research. Clinical Anaesthesiology

At present, short-acting drugs are used in order to achieve the three components of anaesthesia, that is, analgesia, hypnosis and immobility. Assessment of the 'analgesia' component in daily clinical routine is, in contrast to the other components, still based on very unspecific clinical 'end' points such as movement, tearing, tachycardia or hypertension. Individually tailored analgesia, however, should enable to maintain an individual nociceptive-anti-nociceptive balance and better avoid these unwanted responses to surgical stimulation.

Author(s): 
Gruenewald, Matthias
Ilies, Christoph
Publication Title: 
Anesthesia and Analgesia

BACKGROUND: The Composite Variability Index (CVI), derived from the electroencephalogram, was developed to assess the antinociception-nociception balance, whereas the Bispectral Index (BIS) was developed to assess the hypnotic state during anesthesia. We studied the relationships between these indices, level of hypnosis (BIS level), and antinociception (predicted remifentanil effect-site concentrations, CeREMI) before and after stimulation. Also, we measured their association with movement in response to a noxious stimulus.

Author(s): 
Sahinovic, Marco M.
Eleveld, Douglas J.
Kalmar, Alain F.
Heeremans, Eleonora H.
De Smet, Tom
Seshagiri, Chandran V.
Absalom, Anthony R.
Vereecke, Hugo E. M.
Struys, Michel M. R. F.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Artemisia annua L. has been used for many centuries in Chinese traditional medicine. Artemisinin, the active principle was first isolated and identified in the 1970s becoming the global back bone to the fight against malaria. Our research group previously developed an economic and ecological friendly process to obtain this compound. In the pursuit to also exploit the residue generated throughout the process we further evaluated the pharmacological potential of that extract.

Author(s): 
Favero, Fabricio de Faveri
Grando, Rogério
Nonato, Fabiana R.
Sousa, Ilza M. M.
Queiroz, Núbia C. A.
Longato, Giovanna B.
Zafred, Rafael R. T.
Carvalho, João E.
Spindola, Humberto M.
Foglio, Mary A.
Publication Title: 
Pain

The experience of pain can be significantly influenced by expectancy (predictive cues). This ability to modulate pain has the potential to affect therapeutic analgesia substantially and constitutes a foundation for nonpharmacological pain relief. In this study, we investigated (1) brain regions involved in visual cue modulation of pain during anticipation of pain, pain administration, and pain rating; and (2) the association between pretest resting state functional connectivity and the magnitude of cue effects on pain ratings.

Author(s): 
Kong, Jian
Jensen, Karin
Loiotile, Rita
Cheetham, Alexandra
Wey, Hsiao-Ying
Tan, Ying
Rosen, Bruce
Smoller, Jordan W.
Kaptchuk, Ted J.
Gollub, Randy L.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Selaginella convoluta (Arn.) Spring (Selaginellaceae), commonly known as "jericó", is a medicinal plant found in northeastern Brazil. S. convoluta is used in folk medicine as an antidepressant, aphrodisiac, diuretic, analgesic, anti-inflammatory and it is used to combat amenorrhea, coughing and bleeding. This study was performed to evaluate the antinociceptive effects of ethanolic extract from S. convoluta in mice exposed to chemical and thermal models of nociception. METHODS: Preliminary phytochemical analysis of the ethanolic extract was performed.

Author(s): 
de Sá, Pedro Guilherme S.
Nunes, Xirley Pereira
de Lima, Julianeli Tolentino
de Siqueira Filho, José Alves
Fontana, André Paviotti
Siqueira, Jullyana de Souza
Quintans-Júnior, Lucindo José
Damasceno, Patrícia Kauanna Fonseca
Branco, Carla Rodrigues Cardoso
Branco, Alexsandro
Almeida, Jackson Roberto Guedes da Silva
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: The purpose of this study was to investigate if spinal manipulative therapy (SMT) can evoke immediate regional antinociceptive effects in myofascial tissues by increasing pressure pain thresholds (PPTs) over myofascial trigger points in healthy young adults. METHODS: A total of 36 participants (19 men, 17 women; age, 28.0 [5.3] years; body mass index, 26.5 [5.7] kg/m(2)) with clinically identifiable myofascial trigger points in the infraspinatus and gluteus medius muscles were recruited from the University of Guelph, Ontario, Canada.

Author(s): 
Srbely, John Z.
Vernon, Howard
Lee, David
Polgar, Miranda
Publication Title: 
Chronobiology International

We assessed the therapeutic effect of exogenous melatonin (MEL), dexamethasone (DEXA), and a combination of both on nociceptive response induced by chronic inflammation and on the rest-activity circadian rhythm in rats. A total of 64 animals were randomly divided into eight groups of eight rats each: one control group and seven groups with complete Freund's adjuvant-inflamed animals (CFA; injection into the footpad).

Author(s): 
Laste, Gabriela
Vidor, Liliane
de Macedo, Isabel Cristina
Rozisky, Joanna Ripoll
Medeiros, Liciane
de Souza, Andressa
Meurer, Luíse
de Souza, Izabel Cristina Custódio
Torres, Iraci L. S.
Caumo, Wolnei

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