Nuclear Receptor Co-Repressor 1

Publication Title: 
Nature

Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction. Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white adipocytes. Upon food withdrawal Sirt1 protein binds to and represses genes controlled by the fat regulator PPAR-gamma (peroxisome proliferator-activated receptor-gamma), including genes mediating fat storage.

Author(s): 
Picard, FrÈdÈric
Kurtev, Martin
Chung, Namjin
Topark-Ngarm, Acharawan
Senawong, Thanaset
Machado De Oliveira, Rita
Leid, Mark
McBurney, Michael W.
Guarente, Leonard
Publication Title: 
Nature

Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction. Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white adipocytes. Upon food withdrawal Sirt1 protein binds to and represses genes controlled by the fat regulator PPAR-gamma (peroxisome proliferator-activated receptor-gamma), including genes mediating fat storage.

Author(s): 
Picard, FrÈdÈric
Kurtev, Martin
Chung, Namjin
Topark-Ngarm, Acharawan
Senawong, Thanaset
Machado De Oliveira, Rita
Leid, Mark
McBurney, Michael W.
Guarente, Leonard
Publication Title: 
Molecular Endocrinology (Baltimore, Md.)

Ayurveda, the ancient Indian system of health care and medicine, has a well-organized materia medica in which plants form a dominant part. A key illustration of the exploitation of this knowledge toward the development of a modern drug is the isolation and characterization of two antihyperlipidemic compounds, Z-, and E-guggulsterone from the tree Commiphora mukul, the exudate of which has been traditionally used for mitigating lipid disorders.

Author(s): 
Wu, Jun
Xia, Chunsheng
Meier, Jannika
Li, Suzhen
Hu, Xiao
Lala, Deepak S.
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