Nucleoproteins

Publication Title: 
Journal of Molecular Biology
Author(s): 
Air, G. M.
Blackburn, E. H.
Sanger, F.
Coulson, A. R.
Publication Title: 
The Journal of Biological Chemistry

At the core of Saccharomyces cerevisiae telomeres is an array of tandem telomeric DNA repeats bound site-specifically by multiple Rap1 molecules. There, Rap1 orchestrates the binding of additional telomere-associated proteins and negatively regulates both telomere fusion and length homeostasis. Using electron microscopy, viscosity, and light scattering measurements, we show that purified Rap1 is a monomer in solution that adopts a ringlike or C shape with a central cavity.

Author(s): 
Williams, Tanya L.
Levy, Daniel L.
Maki-Yonekura, Saori
Yonekura, Koji
Blackburn, Elizabeth H.
Publication Title: 
Journal of Molecular Biology
Author(s): 
Air, G. M.
Blackburn, E. H.
Sanger, F.
Coulson, A. R.
Subscribe to RSS - Nucleoproteins