The processes that determine an organism's lifespan are complex and poorly understood. Yet single gene manipulations and environmental interventions can substantially delay age-related morbidity. In this review, we focus on the two most potent modulators of longevity: insulin/insulin-like growth factor 1 (IGF-1) signaling and dietary restriction. The remarkable molecular conservation of the components associated with insulin/IGF-1 signaling and dietary restriction allow us to understand longevity from a multi-species perspective.
BACKGROUND: Being awake during anaesthesia is a serious complication. An anaesthetic depth monitor must discriminate in real time between wakefulness and unconsciousness. The present study created a period of wakefulness during propofol-induced hypnosis. Bispectral index (BIS), explicit and implicit memories of the awake period were investigated. METHODS: Ten volunteers were studied. The calculated brain concentration of a target controlled infusion of propofol was increased until loss of response (LOR) to verbal command and then propofol was stopped.
The following aromatherapy study reports the antimicrobial activity of eight Malagasy essential oils by the determination of their respective M.I.C. (Minimal Inhibitory Concentration) on enteropathogenic and spoilage bacteria strains. The aromatic plants used were taken from the Labiatae family (Thymus vulgaris, Ocimum gratissimum), the Myrtaceae family (Eugenia caryophyllata, Melaleuca viridiflora) and the Compositae (Helichrysum lavanduloides, H. bracteiferum, H. gymnocephalum, Psiadia altissima).
