Olfactory Perception

Publication Title: 
PLoS genetics

Organisms perceive changes in their dietary environment and enact a suite of behavioral and metabolic adaptations that can impact motivational behavior, disease resistance, and longevity. However, the precise nature and mechanism of these dietary responses is not known. We have uncovered a novel link between dietary factors and sleep behavior in Drosophila melanogaster.

Linford, Nancy J.
Chan, Tammy P.
Pletcher, Scott D.
Publication Title: 
Schizophrenia Bulletin

Among the sensory modalities, olfaction is most closely associated with the frontal and temporal brain regions that are implicated in schizophrenia and most intimately related to the affective and mnemonic functions that these regions subserve. Olfactory probes may therefore be ideal tools through which to assess the structural and functional integrity of the neural substrates that underlie disease-related cognitive and emotional disturbances.

Turetsky, Bruce I.
Hahn, Chang-Gyu
Borgmann-Winter, Karin
Moberg, Paul J.
Publication Title: 
Hormones and Behavior

Romantic love is one of our most potent and powerful emotions, but very little is known with respect to the hormonal and psychological mechanisms in play. Romantic love is thought to help intimate partners stay committed to each other and two mechanisms have been proposed to mediate this commitment: increased attention towards one's partner or deflected attention away from other potential partners. Both mechanisms find support in the literature.

Lundstrˆm, Johan N.
Jones-Gotman, Marilyn
Publication Title: 
Journal of Autoimmunity

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with more than 100 different autoantibodies, some of which may be associated with specific neuropsychiatric (NPSLE) manifestations. Injection of anti-P ribosomal antibodies (anti-P) directly to the brain ventricles of mice induces depression manifested by increased immobility time in the forced swim test (FST). METHODS: Mice were injected intracerebroventricularily (ICV) with affinity-purified human anti-P antibodies or normal commercial IgG as control.

Katzav, Aviva
Ben-Ziv, Tal
Chapman, Joab
Blank, Miri
Reichlin, Morris
Shoenfeld, Yehuda
Publication Title: 
Current Drug Targets

Molecular medical research on aromatherapy has been steadily increasing for use as an adjuvant therapy in managing psychiatric disorders and to examine its therapeutic mechanisms. Most studies, as well as clinically applied experience, have indicated that various essential oils, such as lavender, lemon and bergamot can help to relieve stress, anxiety, depression and other mood disorders. Most notably, inhalation of essential oils can communicate signals to the olfactory system and stimulate the brain to exert neurotransmitters (e.g. serotonin and dopamine) thereby further regulating mood.

Lv, Xiao Nan
Liu, Zhu Jun
Zhang, Huan Jing
Tzeng, Chi Meng
Publication Title: 
PloS One

BACKGROUND: Cross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function is lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain unclear. We aim to study the role of different types of neurons in cross-modal plasticity. METHODOLOGY/PRINCIPAL FINDINGS: In addition to behavioral tasks in mice, whole-cell recordings at the excitatory and inhibitory neurons, and their two-photon imaging, were conducted in piriform cortex.

Ye, Bing
Huang, Li
Gao, Zilong
Chen, Ping
Ni, Hong
Guan, Sudong
Zhu, Yan
Wang, Jin-Hui
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