Organometallic Compounds

Publication Title: 
Acta Veterinaria Scandinavica
Pekkanen, T. J.
Pekkarinen, K.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

The effects of alpha-dimethylamino-cyclohexoxyl-dimethyl gallium (DCDG), a new antimalarial drug developed in China, on the ultrastructure of murine malaria parasites in vivo was studied in comparison with those of chloroquine (CQ) and artemisinin (Art). All these 3 antimalarials were administered ig to mice at dosages of 1-3, 40-80, and 200-400 for DCDG, CQ, and Art respectively, based on a similar intensity of morphological changes in the parasites. Blood samples were collected for electron microscopy from 15 min to 48 h after medication.

Yan, G. H.
Wang, G. J.
Li, Y. C.
Publication Title: 
Antimicrobial Agents and Chemotherapy

Severe forms of malaria infection, such as cerebral malaria (CM) and acute lung injury (ALI), are mainly caused by the apicomplexan parasite Plasmodium falciparum. Primary therapy with quinine or artemisinin derivatives is generally effective in controlling P. falciparum parasitemia, but mortality from CM and other forms of severe malaria remains unacceptably high. Herein, we report the design and synthesis of a novel carbon monoxide-releasing molecule (CO-RM; ALF492) that fully protects mice against experimental CM (ECM) and ALI.

Pena, Ana C.
Penacho, Nuno
Mancio-Silva, Liliana
Neres, Rita
Seixas, João D.
Fernandes, Afonso C.
Romão, Carlos C.
Mota, Maria M.
Bernardes, Gonçalo J. L.
Pamplona, Ana
Publication Title: 
The Journal of Organic Chemistry

The Pd-catalyzed TBHP-mediated Wacker-type oxidation of internal alkenes is reported. The reaction uses 2-(4,5-dihydro-2-oxazolyl)quinoline (Quinox) as ligand and TBHP(aq) as oxidant to deliver single ketone constitutional isomer products in a predictable fashion from electronically biased olefins. This methodology is showcased through its application on an advanced intermediate in the total synthesis of the antimalarial drug artemisinin.

DeLuca, Ryan J.
Edwards, Jennifer L.
Steffens, Laura D.
Michel, Brian W.
Qiao, Xiaoxiao
Zhu, Chunyin
Cook, Silas P.
Sigman, Matthew S.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Rubia cordifolia L. (Rubiaceae) is an important medicinal plant used in the Ayurvedic medicinal system. Its use as a traditional therapeutic has been related to the treatment of skin disorders and cancer. Besides its medicinal value, anthraquinones from this plant are used as natural food colourants and as natural hair dyes. Dyes derived from natural sources have emerged as important alternatives to synthetic dyes. Alizarin (1,2-dihydroxyanthraquinone) was isolated and characterized from R. cordifolia L. and evaluated for its antigenotoxic potential against a battery of mutagens viz.

Kaur, Prabhjit
Chandel, Madhu
Kumar, Subodh
Kumar, Neeraj
Singh, Bikram
Kaur, Satwinderjeet
Publication Title: 
International Journal of Radiation Biology

PURPOSE: We examined the effects of genistein and/or Eukarion (EUK)-207 on radiation-induced lung damage and investigated whether treatment for 0-14 weeks (wks) post-irradiation (PI) would mitigate late lung injury. MATERIALS AND METHODS: The lungs of female Sprague-Dawley (SD) rats were irradiated with 10 Gy. EUK-207 was delivered by infusion and genistein was delivered as a dietary supplement starting immediately after irradiation (post irradiation [PI]) and continuing until 14 wks PI. Rats were sacrificed at 0, 4, 8, 14 and 28 wks PI.

Mahmood, Javed
Jelveh, Salomeh
Calveley, Victoria
Zaidi, Asif
Doctrow, Susan R.
Hill, Richard P.
Publication Title: 
World journal of gastroenterology: WJG

AIM: To evaluate the efficacy and safety of Traditional Chinese Medicine (TCM) in the treatment of Helicobacter pylori (H. pylori) infection. METHODS: We electronically and manually searched electronic databases, references lists and conferences compilations, and included all randomized clinical trials comparing the treatment of H. pylori using TCM with proton pump inhibitor or colloidal bismuth subcitrate-based triple therapy as controls. The Jadad score was used to assess trial quality, H.

Lin, Jiang
Huang, Wei-Wen
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