Ornithine Decarboxylase

Publication Title: 
Carcinogenesis

Guggulsterone (GUG), a resin of the Commiphora mukul tree, has been used in ayurvedic medicine for centuries to treat a variety of ailments. Recent studies have suggested that GUG may also possess anticancer effects. In the present study, we show that GUG possesses antitumor-promoting effects in SENCAR mouse skin tumorigenesis model. We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.

Author(s): 
Sarfaraz, Sami
Siddiqui, Imtiaz A.
Syed, Deeba N.
Afaq, Farrukh
Mukhtar, Hasan
Publication Title: 
European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP)

The essential oil, emulsion or paste of sandalwood (Santalum album L) has been used in India as an ayurvedic medicinal agent for the treatment of inflammatory and eruptive skin diseases. In this investigation, the chemopreventive effects of sandalwood oil (5% in acetone, w/v) on 7,12-dimethylbenz(a)anthracene-(DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate(TPA)-promoted skin papillomas, and TPA-induced ornithine decarboxylase (ODC) activity in CD1 mice were studied.

Author(s): 
Dwivedi, C.
Abu-Ghazaleh, A.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

The present study was carried out to study the effect of Butea monosperma, a known liver acting drug on the tumor promotion related events of carcinogenesis in rat liver. Thioacetamide (TAA) was used to induce tumor promotion response and oxidative stress and caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in malondialdehyde (MDA) formation, hydrogen peroxide (H(2)O(2)) generation, ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis. However, B.

Author(s): 
Sehrawat, A.
Khan, T. H.
Prasad, L.
Sultana, S.
Publication Title: 
Carcinogenesis

Guggulsterone (GUG), a resin of the Commiphora mukul tree, has been used in ayurvedic medicine for centuries to treat a variety of ailments. Recent studies have suggested that GUG may also possess anticancer effects. In the present study, we show that GUG possesses antitumor-promoting effects in SENCAR mouse skin tumorigenesis model. We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.

Author(s): 
Sarfaraz, Sami
Siddiqui, Imtiaz A.
Syed, Deeba N.
Afaq, Farrukh
Mukhtar, Hasan
Publication Title: 
Carcinogenesis

Guggulsterone (GUG), a resin of the Commiphora mukul tree, has been used in ayurvedic medicine for centuries to treat a variety of ailments. Recent studies have suggested that GUG may also possess anticancer effects. In the present study, we show that GUG possesses antitumor-promoting effects in SENCAR mouse skin tumorigenesis model. We first determined the effect of topical application of GUG to mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.

Author(s): 
Sarfaraz, Sami
Siddiqui, Imtiaz A.
Syed, Deeba N.
Afaq, Farrukh
Mukhtar, Hasan
Publication Title: 
The Journal of Biological Chemistry

Macrophages are essential components of innate immunity, and apoptosis of these cells impairs mucosal defense to microbes. Helicobacter pylori is a gastric pathogen that infects half of the world population and causes peptic ulcer disease and gastric cancer. The host inflammatory response fails to eradicate the organism. We have reported that H. pylori induces apoptosis of macrophages by generation of polyamines from ornithine decarboxylase (ODC), which is dependent on c-Myc as a transcriptional enhancer.

Author(s): 
Asim, Mohammad
Chaturvedi, Rupesh
Hoge, Svea
Lewis, Nuruddeen D.
Singh, Kshipra
Barry, Daniel P.
Algood, Holly S.
de Sablet, Thibaut
Gobert, Alain P.
Wilson, Keith T.
Publication Title: 
Gastroenterology

BACKGROUND & AIMS: Helicobacter pylori-induced immune responses fail to eradicate the bacterium. Nitric oxide (NO) can kill H pylori. However, translation of inducible NO synthase (iNOS) and NO generation by H pylori-stimulated macrophages is inhibited by the polyamine spermine derived from ornithine decarboxylase (ODC), and is dependent on availability of the iNOS substrate L-arginine (L-Arg). We determined if spermine inhibits iNOS-mediated immunity by reducing L-Arg uptake into macrophages.

Author(s): 
Chaturvedi, Rupesh
Asim, Mohammad
Hoge, Svea
Lewis, Nuruddeen D.
Singh, Kshipra
Barry, Daniel P.
de Sablet, Thibaut
Piazuelo, M. Blanca
Sarvaria, Aditya R.
Cheng, Yulan
Closs, Ellen I.
Casero, Robert A.
Gobert, Alain P.
Wilson, Keith T.
Publication Title: 
Photochemistry and Photobiology

Pomegranate from the plant Punica granatum L. possesses strong antioxidant and anti-inflammatory properties. Recently, we have demonstrated that treatment of normal human epidermal keratinocytes with pomegranate fruit extract (PFE) inhibited UVB-mediated activation of nuclear factor kappa B (NF-κB) and mitogen activated protein kinases pathways. Here, we evaluated the effect of PFE on early biomarkers of photocarcinogenesis employing SKH-1 hairless mice. PFE was provided in drinking water (0.2%, wt/vol) to SKH-1 hairless mice for 14 days before a single UVB (180 mJ cm(-2)) irradiation.

Author(s): 
Afaq, Farrukh
Khan, Naghma
Syed, Deeba N.
Mukhtar, Hasan
Publication Title: 
Methods in Molecular Biology (Clifton, N.J.)

Helicobacter pylori is a Gram-negative bacteria that infects the human stomach of half of the world's -population. Colonization is followed by infiltration of the gastric mucosa by lymphocytes and myeloid cells. These cells are activated by various bacterial factors, causing them to produce immune/inflammatory mediators, including reactive nitrogen species and polyamines that contribute to cellular damage and the pathogenesis of H. pylori-associated gastric cancer. In vitro experiments have revealed that H.

Author(s): 
Gobert, Alain P.
Chaturvedi, Rupesh
Wilson, Keith T.
Publication Title: 
Experimental Cell Research

Methionine adenosyltransferase (MAT) is an essential enzyme that is responsible for the biosynthesis of S-adenosylmethionine (SAMe), the principal methyl donor and precursor of polyamines. MAT1A is expressed in normal liver and MAT2A is expressed in all extrahepatic tissues. MAT2A expression is increased in human colon cancer and in colon cancer cells treated with mitogens, whereas silencing MAT2A resulted in apoptosis. The aim of the current work was to examine the mechanism responsible for MAT2A-dependent growth and apoptosis.

Author(s): 
Tomasi, Maria Lauda
Ryoo, Minjung
Skay, Anna
Tomasi, Ivan
Giordano, Pasquale
Mato, José M.
Lu, Shelly C.

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