Osteocalcin

Publication Title: 
Journal of Biomedical Materials Research. Part A

The use of metal implants in dental and orthopedic surgery is continuously expanding and highly successful. While today longevity and load-bearing capacity of the implants fulfill the expectations of the patients, acceleration of osseointegration would be of particular benefit to shorten the period of convalescence. To further clarify the options to accelerate the kinetics of osseointegration, within this study, the osteogenic properties of structurally identical surfaces with different metal coatings were investigated.

Author(s): 
Hofstetter, Wilhelm
Sehr, Harald
de Wild, Michael
Portenier, Jeannette
Gobrecht, Jens
Hunziker, Ernst B.
Publication Title: 
Archives of Internal Medicine

BACKGROUND: Calorie restriction (CR) is promoted to increase longevity, yet this regimen could lead to bone loss and fracture and therefore affect quality of life. METHODS: Forty-six individuals were randomized to 4 groups for 6 months: (1) healthy diet (control group); (2) 25% CR from baseline energy requirements (CR group); (3) 25% energy deficit by a combination of CR and increased aerobic exercise (CR + EX group); and (4) low-calorie diet (890 kcal/d; goal, 15% weight loss) followed by weight maintenance (LCD group).

Author(s): 
Redman, Leanne M.
Rood, Jennifer
Anton, Stephen D.
Champagne, Catherine
Smith, Steven R.
Ravussin, Eric
Pennington Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Research Team
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

INTRODUCTION: The purpose of this 3-way crossover study was to identify the effective dose of soy protein isolate enriched with isoflavones for suppressing bone resorption in postmenopausal women using a novel, rapid assessment of antibone resorbing treatments. METHODS: Thirteen postmenopausal women (>or=6 yr since menopause) were predosed with 41Ca iv. After a 200-d baseline period, subjects were given 43 g soy protein/d that contained 0, 97.5, or 135.5 mg total isoflavones in randomized order. The soy protein isolate powder was incorporated into baked products and beverages.

Author(s): 
Cheong, J. M. K.
Martin, B. R.
Jackson, G. S.
Elmore, D.
McCabe, G. P.
Nolan, J. R.
Barnes, S.
Peacock, M.
Weaver, C. M.
Publication Title: 
Bone

Preterm delivery (<37 weeks post-menstrual age) is associated with suboptimal bone mass. We hypothesized that tactile/kinesthetic stimulation (TKS), a form of infant massage that incorporates kinesthetic movement, would increase bone strength and markers of bone accretion in preterm infants. Preterm, AGA infants (29-32 weeks) were randomly assigned to TKS (N=20) or Control (N=20). Twice daily TKS was provided 6 days per week for 2 weeks. Control infants received the same care without TKS treatment. Treatment was masked to parents, health care providers, and study personnel.

Author(s): 
Haley, S.
Beachy, J.
Ivaska, K. K.
Slater, H.
Smith, S.
Moyer-Mileur, L. J.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The effect of massage therapy on bone metabolism in adults has only scarcely been explored. In a randomized crossover trial, we investigated the skeletal effect of Thai traditional massage by examining the changes in biochemical markers of bone turnover. METHODS: Forty-eight postmenopausal women participated in the study. All volunteers were randomized to a 2-hour session of Thai traditional massage twice a week for 4 weeks and a 4-week control period after a 2-week washout, or vice versa.

Author(s): 
Saetung, Sunee
Chailurkit, La-Or
Ongphiphadhanakul, Boonsong
Publication Title: 
International Journal of Molecular Sciences

Safflower (Carthamus tinctorius L.) seeds are used as a folk medicine to enhance bone formation or to prevent osteoporosis in Korea. Therefore, the methanolic extract of safflower seeds (MESS) containing high mineral content, such as calcium (Ca), potassium (K) and phosphorous (P), was evaluated for the role on osteoblast (Ob) markers of Sprague-Dawley rats. In serum of 3 to 11 weeks (wks) old rats, both osteocalcin (OC) content and bone-specific alkaline phosphatase (B-ALP) activity increased to their maximum levels in 4-7 wks.

Author(s): 
Lee, Young Seok
Choi, Chang Won
Kim, Jae Jin
Ganapathi, Andy
Udayakumar, Rajangam
Kim, Sei Chang
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Higher protein diets are promoted for effective weight loss. Striated tissues in omnivorous diets contain high-quality protein, but limited data exist regarding their effects on bone. METHODS: To examine the effects of energy restriction-induced weight loss with higher protein omnivorous diets versus lower protein vegetarian diets on bone mineral density in overweight postmenopausal women, two randomized controlled feeding studies were conducted.

Author(s): 
Campbell, Wayne W.
Tang, Minghua
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear. OBJECTIVE: This study examined and determined predictors of vitamin K status in subjects aged 8-25 y with CF and pancreatic insufficiency taking various vitamin K supplements.

Author(s): 
Dougherty, Kelly A.
Schall, Joan I.
Stallings, Virginia A.
Publication Title: 
The Journal of Nutrition

Although vitamin D deficiency is common at birth, the consequences to growth and bone mass by weaning are unclear. This study was designed to determine whether maternal dietary vitamin D deficiency in pregnancy has a negative impact on the bone mass of full-term neonates and if postnatal supplementation could restore bone mass. Forty guinea pigs were randomized to receive a control (C) or deficient (D) diet (0.03 microg vs. 0.00 microg cholecalciferol/g) during pregnancy.

Author(s): 
Finch, Sarah L.
Rauch, Frank
Weiler, Hope A.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear. OBJECTIVE: This study examined and determined predictors of vitamin K status in subjects aged 8-25 y with CF and pancreatic insufficiency taking various vitamin K supplements.

Author(s): 
Dougherty, Kelly A.
Schall, Joan I.
Stallings, Virginia A.

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