Osteoporosis

Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: Homeopathy is based on treatment by similitude ('like cures like') administering to sick individuals substances that cause similar symptoms in healthy individuals, employing the secondary and paradoxical action of the organism as therapeutic response. This vital or homeostatic reaction of the organism can be scientifically explained by the rebound effect of drugs, resulting in worsening of symptoms after suspension of treatment.

Author(s): 
Teixeira, Marcus Zulian
Publication Title: 
Polskie Archiwum Medycyny Wewn?trznej

Osteoporosis is a skeletal disease characterized by the increased risk of fractures, decreased bone mass and bone quality. The number of patients suffering from osteoporosis still increase due to the extension of the lifespan in the developed countries. The low-energy hip fractures are the most severe complications of the disease, lethal in some cases. The number of hip-fractures in Poland exceeds 30,000 per year. Senile osteoporosis makes 20% of primary osteoporosis. The calcium and vitamin D3 intake from diet or their supplementation are crucial in the ethiopathogenesis of this disease.

Author(s): 
Wawrzyniak, Anna
Horst-Sikorska, Wanda
Publication Title: 
Journal of Nutritional Science and Vitaminology

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age.

Author(s): 
Fujita, T.
Publication Title: 
Journal of Nutritional Science and Vitaminology

Calcium deficiency is a constant menace to land-abiding animals, including mammals. Humans enjoying exceptional longevity on earth are especially susceptible to calcium deficiency in old age.

Author(s): 
Fujita, T.
Publication Title: 
Public Health Reports (Washington, D.C.: 1974)

Women can adopt health practices that will help them to maintain good health throughout their various life stages. Women can take charge of their health by maintaining a nutritionally balanced diet, exercising, and using common sense. Women can also employ known preventive measures against osteoporosis, stroke, lung and breast cancer and accidents. Because women experience increased longevity and may require long-term care with age, the need for restructuring the nation's care system for the elderly becomes an important women's health concern.

Author(s): 
Newman, D. M.
Publication Title: 
The American Journal of Clinical Nutrition

Bone mass declines progressively with age in both men and women from the age of approximately 30 y. Increased longevity will inevitability be associated with an increase in the incidence of osteoporosis, its associated complications, and incurred health care costs. Current pharmacologic approaches focus on inhibiting bone resorption in those with osteoporosis but do little to improve bone mass. Increased understanding of the cellular events responsible for normal bone formation has led to multiple pathways that can be targeted to positively influence bone mass.

Author(s): 
Mundy, Gregory R.
Publication Title: 
Experimental Gerontology

Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the proximal femur is the most frequently involved site. Bone remodelling can maintain circulating calcium within physiological ranges, at the expense of a substantial loss of this ion from the skeleton, particularly during senescence.

Author(s): 
Passeri, Giovanni
Vescovini, Rosanna
Sansoni, Paolo
Galli, Carlo
Franceschi, Claudio
Passeri, Mario
Italian Multicentric Study on Centenarians (IMUSCE)
Publication Title: 
PloS One

BACKGROUND: Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the population-based Health Aging and Body Composition (Health ABC) Study and in two replication samples (the TwinsUK Study and the Amish Family Osteoporosis Study, AFOS). METHODOLOGY: Five variants were identified in the TERC region by sequence analysis and only one SNP was common (rs2293607, G/A).

Author(s): 
Njajou, Omer T.
Blackburn, Elizabeth H.
Pawlikowska, Ludmila
Mangino, Massimo
Damcott, Coleen M.
Kwok, Pui-Yan
Spector, Timothy D.
Newman, Anne B.
Harris, Tamara B.
Cummings, Steven R.
Cawthon, Richard M.
Shuldiner, Alan R.
Valdes, Ana M.
Hsueh, Wen-Chi
Publication Title: 
Chang Gung Medical Journal

BACKGROUND: The plant Cissus quadrangularis (CQ) is used as an osteoprotective agent in Ayurveda, the Indian system of alternative medicine. The present study was done to validate the anti-osteoporotic role of the petroleum ether extract of CQ on ovariectomy-induced osteoporosis in rats. METHODS: Female wistar rats were divided into five groups of six rats each; (1) The Normal control (NC) group (n=6) received no surgery and no treatment, (2).

Author(s): 
Potu, Bhagath Kumar
Rao, Muddanna S.
Nampurath, Gopalan Kutty
Chamallamudi, Mallikarjuna Rao
Nayak, Soubhagya Ranjan
Thomas, Huban
Publication Title: 
Molecular cancer research: MCR

Most patients with cancer die not because of the tumor in the primary site, but because it has spread to other sites. Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone. It is now well recognized that osteoclasts are responsible for the osteolysis observed in bone metastases of the tumor.

Author(s): 
Reuter, Simone
Prasad, Sahdeo
Phromnoi, Kanokkarn
Kannappan, Ramaswamy
Yadav, Vivek R.
Aggarwal, Bharat B.

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