Ovalbumin

Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

CD4 T cells can be primarily polarized to differentiate into Th1 or Th2 cells. CD44 is a marker of T cell activation and a property of long-lived memory cells and implicated in cell migration, activation, and differentiation. To date, whether CD44 has a role in regulating Th1-Th2 differentiation has not been determined. In this study, we compared Th1 and Th2 responses in wild-type and CD44-deficient mice in response to sheep RBC and chicken OVA, as well as examined Th1-Th2 differentiation in vivo and in vitro from CD44-sufficient and CD44-deficient naive CD4 T cells.

Author(s): 
Guan, Hongbing
Nagarkatti, Prakash S.
Nagarkatti, Mitzi
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: For almost 2000 years it has been recognized that aqueous extracts from pine cones possess medicinal properties beneficial for the treatment of a broad variety of diseases and conditions. In this report, the ability of an orally administered poly phenylpropanoid-polysaccharide rich extract of pine cones (PPC) to suppress the generation of IgE and to significantly enhance antigen-specific cellular responses to a variety of vaccines was tested.

Author(s): 
Burrows, Mike
Assundani, Deepak
Celis, Esteban
Tufaro, Frank
Tanaka, Akiko
Bradley, W. Guy
Publication Title: 
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

BACKGROUND: Chronic allergic asthma is the result of a T-helper type 2 (Th2)-biased immune status. Current asthma therapies control symptoms in some patients, but a long-lasting therapy has not been established. Anti-Asthma Simplified Herbal Medicine Intervention (ASHMI™), a Chinese herbal formula, improved symptoms and lung function, and reduced Th2 responses in a controlled trial of patients with persistent moderate to severe asthma.

Author(s): 
Srivastava, K.
Zhang, T.
Yang, N.
Sampson, H.
Li, X. M.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

It is reported that PTP1B limits cytokine signaling in vitro. However, PTP1B's function during inflammation in vivo is not known. In this report, we determined whether PTP1B deficiency affects allergic inflammation in vivo. Briefly, lungs of OVA-challenged PTP1B(-/-) mice had elevated numbers of eosinophils and eosinophil progenitors at 6 h after one OVA challenge and at 24 h after a third OVA challenge as compared with OVA-challenged wild-type mice.

Author(s): 
Berdnikovs, Sergejs
Pavlov, Vladimir I.
Abdala-Valencia, Hiam
McCary, Christine A.
Klumpp, David J.
Tremblay, Michel L.
Cook-Mills, Joan M.
Publication Title: 
American Journal of Physiology. Lung Cellular and Molecular Physiology

Clinical reports indicate that patients with allergy/asthma commonly have associated symptoms of anxiety/depression. Anxiety/depression can be reduced by 5-hydroxytryptophan (5-HTP) supplementation. However, it is not known whether 5-HTP reduces allergic inflammation. Therefore, we determined whether 5-HTP supplementation reduces allergic inflammation. We also determined whether 5-HTP decreases passage of leukocytes through the endothelial barrier by regulating endothelial cell function.

Author(s): 
Abdala-Valencia, Hiam
Berdnikovs, Sergejs
McCary, Christine A.
Urick, Daniela
Mahadevia, Riti
Marchese, Michelle E.
Swartz, Kelsey
Wright, Lakiea
Mutlu, Gökhan M.
Cook-Mills, Joan M.
Publication Title: 
American Journal of Physiology. Lung Cellular and Molecular Physiology

Pulmonary eosinophilia is a consistent hallmark of allergic lung inflammation. Infiltration of eosinophils into ovalbumin (OVA)-challenged lungs is dependent on the adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells. Ligation of VCAM-1 activates endothelial cell protein tyrosine phosphatase 1B (PTP1B), which is required for VCAM-1-dependent leukocyte migration in vitro.

Author(s): 
Berdnikovs, Sergejs
Abdala-Valencia, Hiam
Cook-Mills, Joan M.
Publication Title: 
Current Medicinal Chemistry. Cardiovascular and Hematological Agents

Food proteins can be a source of various bioactive peptides including such possessing anti-hypertensive activity. While most orally active anti-hypertensive peptides derived from food proteins inhibit the angiotensin I-converting enzyme (ACE), ovokinin (2-7) (RADHPF), a peptide isolated from a chymotryptic digest of ovalbumin, has been shown to induce nitric oxide-dependent vasorelaxation in an isolated mesenteric artery as well as anti-hypertensive effect after oral administration in spontaneously hypertensive rats (SHRs).

Author(s): 
Matoba, Nobuyuki
Yamada, Yuko
Yoshikawa, Masaaki
Publication Title: 
World journal of gastroenterology: WJG

AIM: To develop a Brown Norway (BN) rat model to determine the potential allergenicity of novel proteins in genetically modified food. METHODS: The allergenicity of different proteins were compared, including ovalbumin (OVA), a potent respiratory and food allergen, bovine serum albumin (BSA), a protein that is considered to have a lesser allergenic potential, and potato acid phosphatase (PAP), a non-allergenic protein when administered to BN rats via different routes of exposure (intraperitoneally or by gavage). IgG and IgE antibody responses were determined by ELISA and PCA, respectively.

Author(s): 
Jia, Xu-Dong
Li, Ning
Wu, Yong-Ning
Yang, Xiao-Guang
Publication Title: 
Vaccine

Safe and cost-effective adjuvants are a critical requirement for subunit vaccine development. We report here the in vivo activity of a series of fully synthetic LPS receptor agonists that have been shown to activate NF-kappaB signaling through the Toll-like receptor 4 (TLR4). These compounds boost antibody responses to protein antigens when coadministered at microgram doses in mice. At these dosage levels no adverse effects are observed. Antibody responses are largely IgG1, with enhanced IgG2a, and down-regulated IgE as compared to alum adjuvanted immunization.

Author(s): 
Przetak, Melinda
Chow, Jesse
Cheng, Hongsheng
Rose, Jeffrey
Hawkins, Lynn D.
Ishizaka, Sally T.
Publication Title: 
Immunology

Asthma is a chronic disease characterized by airway inflammation caused by the dysregulated production of cytokines secreted by allergen-specific type 2 T helper (Th2) cells. Antrodia camphorata is a commonly used fungus in Asian folk medicine, and A. camphorata polysaccharides are reported to possess anti-cancer activities. In this study, the immunomodulatory effects of purified fractionated polysaccharides (GF2) from A. camphorata on dendritic cells (DCs) and their potential preventive effects against ovalbumin (OVA) -induced asthma were investigated.

Author(s): 
Liu, Ko-Jiunn
Leu, Sy-Jye
Su, Ching-Hua
Chiang, Bor-Luen
Chen, Yi-Lien
Lee, Yueh-Lun

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