Publication Title: 
International Immunopharmacology

BACKGROUND: Cissampelos sympodialis Eichl. (Menispermaceae) is a plant found in Northeastern and Southeast of Brazil and hot water infusion of C. sympodialis root bark is largely used in the indigenous and folk medicine to treat several inflammatory disorders, including asthma. Asthma is a chronic inflammatory allergic disease characterized by airway hyperreactivity (AHR), eosinophil tissue infiltration and lung remodeling. The aim of this study was to evaluate the therapeutic effect of C.

Bezerra-Santos, Claudio R.
Vieira-de-Abreu, Adriana
Vieira, Giciane Carvalho
Filho, Jaime R.
Barbosa-Filho, José Maria
Pires, Ana Lucia
Martins, Marco Aurelio
Souza, Heitor S.
Bandeira-Melo, Christianne
Bozza, Patrícia T.
Piuvezam, Marcia R.
Publication Title: 
International Immunopharmacology

Food allergy is a severe human disease with imminent risk of life. Cissampelos sympodialis (Menispermaceae) is a native Brazilian plant used in Brazilian folk medicine for the treatment of respiratory allergies. In this study the experimental model of food allergy induced by ovalbumin (OVA) was used to determine whether the alcoholic extract of the plant (AFL) and its alkaloids match a therapeutic approach for this disease.

Costa, Hermann Ferreira
Leite, Fagner Carvalho
Alves, Adriano Francisco
Barbosa-Filho, José Maria
dos Santos, Claudio Roberto Bezerra
Piuvezam, Marcia Regina
Publication Title: 
Toxicologic Pathology

Compared to healthy subjects, individuals with allergic airway disease (e.g., asthma, allergic rhinitis) have enhanced inflammatory responses to inhaled ozone. We created a rodent model of ozone-enhanced allergic nasal responses in Brown Norway rats to test the therapeutic effects of the dietary supplement gamma-tocopherol (gammaT). Ovalbumin (OVA)-sensitized rats were intranasally challenged with 0% or 0.5% OVA (in saline) on Days 1 and 2, and then exposed to 0 or 1 ppm ozone (eight hours/day) on Days 4 and 5.

Wagner, James G.
Harkema, Jack R.
Jiang, Qing
Illek, Beate
Ames, Bruce N.
Peden, David B.
Publication Title: 
Biological & Pharmaceutical Bulletin

In the theory of traditional Chinese medicine (TCM), eqi ([Symbol: see text]) circulates at the superficial portion of the body to guard against exopathogen. Gyokuheifusan (GHS; [Symbol: see text]), containing Astragalus Root, Atractylodes Rhizome, and Saposhnikovia Root, is a TCM formula to treat the insufficiency of eqi by invigorating qi and consolidating the superficial resistance. In this study, we evaluated the effect of GHS on murine antibody production against ovalbumin (OVA) used as exopathogen.

Makino, Toshiaki
Sasaki, Shin-Ya
Ito, Yoshiaki
Kano, Yoshihiro
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Gyokuheifusan (GHS, Jade Windscreen Powder in English, Yupingfengsan in Chinese) is an herbal formula in traditional Kampo medicine which consolidates superficial resistance to protect against invasion by external pathogens. This review describes the immunopharmacologic properties of GHS as a holistic Kampo medicine, which can affect human homeostasis and constitution of human beings. Oral treatment with GHS has preventive and curative effects in allergic rhinitis induced by Japanese cedar pollen in guinea pigs.

Makino, Toshiaki
Publication Title: 
Biological & Pharmaceutical Bulletin

Asthma, a common, chronic lung disease in industrialized countries, is characterized by the production of large quantities of IgE antibody by B cells and a decrease of the IFN-gamma/IL-4 (Th1/Th2) ratio. Gyokuheifusan (GHS) is a classical formulation of traditional Chinese medicine (TCM) that is usually prescribed to prevent or treat respiratory tract diseases, such as respiratory infection and bronchial asthma. In order to evaluate the possible effectiveness of GHS on bronchial asthma, its immunomodulatory activity was examined in ovalbumin (OVA)-induced asthma model mice.

Fang, Su-Ping
Tanaka, Takeshi
Tago, Fumitosi
Okamoto, Takuya
Kojima, Shuji
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Periploca sepium Bge, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. Followed the bioactivity-guided isolation, the most potent immunosuppressive compound, periplocoside E (PSE), a pregnane glycoside, had been identified from P. sepium Bge. We investigated the immunosuppressive effects of PSE in vitro and in vivo. The results showed that PSE in a dose-dependent manner significantly inhibited the proliferation of splenocytes induced by concanavalin A and mixed lymphocyte culture reaction at no cytotoxic concentrations (<5 microM).

Zhu, Yi-Na
Zhao, Wei-min
Yang, Yi-fu
Liu, Qun-Fang
Zhou, Yu
Tian, Jia
Ni, Jia
Fu, Yun-Feng
Zhong, Xiang-Gen
Tang, Wei
Zhou, Ru
He, Pei-Lan
Li, Xiao-yu
Zuo, Jian-ping
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Many formulae of traditional Chinese medicines (TCMs) have been used for antiasthma treatment dating back many centuries. There is evidence to suggest that TCMs are effective as a cure for this allergenic disease administered via gastric tubes in animal studies; however, their efficacy, safety and side effects as an asthmatic therapy are still unclear.

Chang, Hung-Chou
Gong, Cheng-Chung
Chen, Ji-Liang
Mak, Oi-Tong
Publication Title: 
Iranian Journal of Allergy, Asthma, and Immunology

In traditional Chinese medicine, arsenous compounds, including arsenic trioxide (ATO), are often used to treat many diseases, which are safe and effective. Recently, studies have indicated that Th17- IL-17 involved in the pathogenesis and development of asthma. The goal of this study was to investigate the effect and mechanism of ATO on asthma, especially the Th17- IL-17 axis.We used oval bumin (OVA)-immunized mice as a model for asthma and treated mice with ATO or dexamethasone.

Zhang, Li
Li, Keng
Bing Ma, Li
Gong, Su-bo
Wang, Gu-yi
Liu, Yi
Ji, Xiao-ying
Xu, Li
Liu, Shao-kun
Chen, Ping
Ouyang, Ruo-yun
Xiang, Xu-dong
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Arecae semen, the dried slice of areca nuts, is a traditional Chinese medicine used to treat intestinal parasitosis, rectal tenesmus and diarrhea. Areca nuts contain a rich amount of polyphenols that have been shown to modulate the functionality of mast cells and T cells. The objective of this study is to investigate the effect of polyphenol-enriched areca nut extracts (PANE) against food allergy, a T cell-mediated immune disorder. METHODS: BALB/c mice were left untreated or administered with PANE (0.05% and 0.1%) via drinking water throughout the entire experiment.

Wang, Chia-Chi
Lin, Yu-Ru
Liao, Mei-Hsiu
Jan, Tong-Rong


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