Ovarian Neoplasms

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: This is the second update of the review first published in the Cochrane Database of Systematic Reviews in 2009, Issue 1. Epithelial ovarian cancer is diagnosed in over 200,000 women worldwide each year. Ten to 20% of women are diagnosed early, when there is still a good possibility of cure. The treatment of early-stage (stage I and IIa) disease involves surgery to remove the disease, often followed by chemotherapy (adjuvant chemotherapy).

Author(s): 
Lawrie, Theresa A.
Winter-Roach, Brett A.
Heus, Pauline
Kitchener, Henry C.
Publication Title: 
Medical Oncology (Northwood, London, England)

The forkhead box proteins (FOXO proteins) comprise a large family of functionally diverse transcription factors involved in cellular proliferation, transformation, differentiation and longevity. Recently, ubiquitination and proteasome degradation of FOXO3a have been reported. In this study, we investigated the role of FOXO3a and Skp2 in human ovarian cancer. We detected the expression of FOXO3a and Skp2 in ovarian cancer by immunohistochemistry (IHC) and analyzed the relationship of FOXO3a and Skp2 with clinicopathological parameters, including prognosis.

Author(s): 
Lu, Mudan
Zhao, Yueming
Xu, Fei
Wang, Yong
Xiang, Jingying
Chen, Daozhen
Publication Title: 
BMC cancer

BACKGROUND: Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers in addition to infections. DISCUSSION: Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitutes part of the human genome.

Author(s): 
Cegolon, Luca
Salata, Cristiano
Weiderpass, Elisabete
Vineis, Paolo
Pal˘, Giorgio
Mastrangelo, Giuseppe
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Ovarian cancer ranks fifth in cancer fatalities among American women. Although curable at early stages with surgery, most women are diagnosed with symptoms of late-stage metastatic disease. Moreover, none of the current diagnostic techniques are clinically recommended for at-risk women as they preferentially target low-grade tumors (which do not affect longevity) and fail to capture early signatures of more lethal serous tumors which originate in the fimbrae region of the fallopian tubes. Hence, the early detection of ovarian cancer is challenging given the current strategy.

Author(s): 
Damania, Dhwanil
Roy, Hemant K.
Kunte, Dhananja
Hurteau, Jean A.
Subramanian, Hariharan
Cherkezyan, Lusik
Krosnjar, Nela
Shah, Maitri
Backman, Vadim
Publication Title: 
BMC cancer

BACKGROUND: Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers in addition to infections. DISCUSSION: Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitutes part of the human genome.

Author(s): 
Cegolon, Luca
Salata, Cristiano
Weiderpass, Elisabete
Vineis, Paolo
Pal˘, Giorgio
Mastrangelo, Giuseppe
Publication Title: 
Journal of Stem Cells

Since Rita Levi Montalcini and Stanley Cohen received Nobel Prize for their pioneering work on nerve growth factor (NGF), its role in female reproductive system has been reinforced in last two decades. The neurotrophins (NT) including nerve growth factor (NGF) are a family of related growth factors and their respective receptor tyrosine kinases that are of major importance in the regulation of neuronal survival and differentiation.

Author(s): 
Bose, Chinmoy K.
Publication Title: 
Psychology, Health & Medicine

This study explored whether Smith and Lazarus' (1990, 1993) cognitive theory of emotion could predict emotional responses to an emotionally ambiguous real-life situation. Questionnaire data were collected from 145 women upon referral for cancer genetic risk assessment. These indicated a mixed emotional reaction of both positive and negative emotions to the assessment. Hierarchical regression analyses revealed that the hypothesised models explained between 20% and 33% of the variance of anxiety, hope and gratitude scores, but only 10% of the variance for challenge scores.

Author(s): 
Phelps, Ceri
Bennett, Paul
Brain, Kate
Publication Title: 
European Journal of Oncology Nursing: The Official Journal of European Oncology Nursing Society

BACKGROUND: Women with recurring ovarian cancer are living longer, due to advances in treatment options. They are now often outpatients, experiencing rapid encounters on treatment days. Whether this shift in care meets women's needs has been scarcely explored scientifically. PURPOSE OF THE STUDY: This study aimed to illuminate the phenomenon of living with recurring ovarian cancer as experienced by women in that condition. METHODS AND SAMPLE: A descriptive phenomenological method was used.

Author(s): 
Ekwall, Eva
Ternestedt, Britt-Marie
Sorbe, Bengt
Sunvisson, Helena
Publication Title: 
Genetic Testing

This study sought to investigate the impact of BRCA1 and BRCA2 mutation searching on women previously diagnosed with breast or ovarian cancer. In-depth interviews were undertaken with 30 women who had undergone a BRCA1 and BRCA2 mutation search within the clinical setting. The main reasons reported for undergoing mutation searching were: to provide genetic information for other family members, general altruism, curiosity about the aetiology of cancer, and to provide information to facilitate risk management decisions.

Author(s): 
Hallowell, N.
Foster, C.
Ardern-Jones, A.
Eeles, R.
Murday, V.
Watson, M.
Publication Title: 
The New Zealand Medical Journal

The combined use of trance (hypnosis) and conjoint family therapy to meet certain needs of a patient with terminal cancer and her family is described. The potential value of these two approaches used in conjunction with normal medical management is shown.

Author(s): 
Pettitt, G. A.

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