Ovulation

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Polycystic ovarian syndrome (PCOS) is characterised by the clinical signs of oligo-amenorrhoea, infertility and hirsutism. Conventional treatment of PCOS includes a range of oral pharmacological agents, lifestyle changes and surgical modalities. Beta-endorphin presents in the follicular fluid of both normal and polycystic ovaries.

Author(s): 
Lim, Chi Eung Danforn
Ng, Rachel W. C.
Xu, Ke
Cheng, Nga Chong Lisa
Xue, Charlie C. L.
Liu, Jian Ping
Chen, Nini
Publication Title: 
Human Reproduction Update

BACKGROUND: Here we describe the consensus guideline methodology, summarise the evidence-based recommendations we provided to the World Health Organisation (WHO) for their consideration in the development of global guidance and present a narrative review on the management of anovulatory infertility in women with polycystic ovary syndrome (PCOS). OBJECTIVE AND RATIONALE: The aim of this paper was to present an evidence base for the management of anovulatory PCOS.

Author(s): 
Balen, Adam H.
Morley, Lara C.
Misso, Marie
Franks, Stephen
Legro, Richard S.
Wijeyaratne, Chandrika N.
Stener-Victorin, Elisabet
Fauser, Bart C. J. M.
Norman, Robert J.
Teede, Helena
Publication Title: 
Experimental Gerontology
Author(s): 
Everitt, A. V.
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: Acupuncture may represent a nonpharmaceutical treatment for women with polycystic ovary syndrome (PCOS), based on four studies. OBJECTIVE: The objective of the study was to determine whether true, as compared with sham, acupuncture normalizes pituitary gonadotropin hormones and increases ovulatory frequency in women with PCOS. DESIGN: This was a randomized, double-blind, sham-controlled clinical trial (5 month protocol). SETTING: The study was conducted in central Virginia. PARTICIPANTS: Eighty-four reproductive-aged women completed the intervention.

Author(s): 
Pastore, Lisa M.
Williams, Christopher D.
Jenkins, Jeffrey
Patrie, James T.
Publication Title: 
Prostaglandins, Leukotrienes, and Essential Fatty Acids

Prevention of ovarian cancer is the best approach for reducing the impact of this deadly disease. The laying hen is a robust model of spontaneous ovarian cancer that recapitulates the human disease. Dietary intervention with flaxseed, the richest vegetable source of omega-3 fatty acids (OM-3FAs) and phytoestrogen lignans, demonstrate the potential for effective prevention and amelioration of ovarian cancer by targeting inflammatory prostaglandin pathways.

Author(s): 
Eilati, Erfan
Hales, Karen
Zhuge, Yan
Ansenberger Fricano, Kristine
Yu, Rui
van Breemen, Richard B.
Hales, Dale Buchanan
Publication Title: 
Fertility and Sterility

OBJECTIVE: To determine whether foot reflexology, a complementary therapy, has an effect greater than sham reflexology on induction of ovulation. DESIGN: Sham-controlled randomized trial with patients and statistician blinded. SETTING: Infertility clinic in Plymouth, United Kingdom. PATIENT(S): Forty-eight women attending the clinic with anovulation. INTERVENTION(S): Women were randomized to receive eight sessions of either genuine foot reflexology or sham reflexology with gentle massage over 10 weeks.

Author(s): 
Holt, Jane
Lord, Jonathan
Acharya, Umesh
White, Adrian
O'Neill, Nyree
Shaw, Steve
Barton, Andy
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

The present study tests the hypothesis that specific endocrine, metabolic, and anthropometric features distinguish obese women with polycystic ovary syndrome (PCOS) who resume ovulation in response to calorie restriction and weight loss from those who do not. Fifteen obese (body mass index 39 +/- 7 kg/m(2)) hyperandrogenemic oligoovulatory patients undertook a very low calorie diet (VLCD), wherein each lost > or =10% of body weight over a mean of 6.25 mo. Body fat distribution was quantitated by magnetic resonance imaging.

Author(s): 
van Dam, Eveline W. C. M.
Roelfsema, Ferdinand
Veldhuis, Johannes D.
Hogendoorn, Simone
Westenberg, Jos
Helmerhorst, Frans M.
Frölich, Marijke
Krans, H. Michiel J.
Meinders, A. Edo
Pijl, Hanno
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Clinical studies of women from the United States demonstrate a sensitivity of the ovarian system to energetic stress. Even moderate exercise or caloric restriction can lead to lower progesterone levels and failure to ovulate. Yet women in many nonindustrial populations experience as many as a dozen pregnancies in a lifetime despite poor nutritional resources, heavy workloads, and typical progesterone levels only about two-thirds of those of U.S. women. Previous cross-sectional studies of progesterone may, however, suffer from inadvertent selection bias.

Author(s): 
Vitzthum, Virginia J.
Spielvogel, Hilde
Thornburg, Jonathan
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: Acupuncture may represent a nonpharmaceutical treatment for women with polycystic ovary syndrome (PCOS), based on four studies. OBJECTIVE: The objective of the study was to determine whether true, as compared with sham, acupuncture normalizes pituitary gonadotropin hormones and increases ovulatory frequency in women with PCOS. DESIGN: This was a randomized, double-blind, sham-controlled clinical trial (5 month protocol). SETTING: The study was conducted in central Virginia. PARTICIPANTS: Eighty-four reproductive-aged women completed the intervention.

Author(s): 
Pastore, Lisa M.
Williams, Christopher D.
Jenkins, Jeffrey
Patrie, James T.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Polycystic ovary syndrome (PCOS) affects 5-10 percent of all fertile women and is associated with anovulation/oligoovulation, hyperandrogenism, and polycystic ovaries. Pharmacological treatment is often effective but associated with unwanted side effects. Acupuncture treatments have been shown to improve menstrual bleeding patterns and ovulation as well as hyperandrogenism, without side effects. The purpose of the present study was to describe the experience of acupuncture for women diagnosed with PCOS.

Author(s): 
Billhult, Annika
Stener-Victorin, Elisabet

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