Publication Title: 
Forschende Komplementarmedizin Und Klassische Naturheilkunde = Research in Complementary and Natural Classical Medicine

BACKGROUND: Independent replications of preclinical investigations of homeopathic potencies are rare. However, they are a necessary tool to determine the relevant factors modulating the effects of homeopathic potencies in preclinical systems. OBJECTIVE: The goal of the present study was to reproduce a trial published in 1997. An Italian group of researchers investigated the effect of Arsenicum album 45x on the growth of wheat which had been previously poisoned with a material dose of Arsenicum album.

Binder, Mascha
Baumgartner, Stephan
Thurneysen, André
Publication Title: 
Forschende Komplementärmedizin Und Klassische Naturheilkunde = Research in Complementary and Natural Classical Medicine

BACKGROUND: Most criticism of homeopathy concerns the lack of scientific bases and theoretical models. Fundamental research could make important contributions to our understanding of the mechanisms of action of homeopathic treatments. Plant-based bioassays are suitable for basic research -- lacking the placebo effect and ensuring large data samples for structured statistical analyses.

Brizzi, Maurizio
Lazzarato, Lisa
Nani, Daniele
Borghini, Francesco
Peruzzi, Maurizio
Betti, Lucietta
Publication Title: 
Forschende Komplementärmedizin (2006)

A series of experiments, performed on plant models with ultra high dilutions (UHD) of arsenic trioxide at 45th decimal potency has been reviewed with a particular focus on variability. The working variables considered are: the number of germinated seeds out of a fixed set of 33, the stem length of wheat seedlings and the number of necrotic lesions in tobacco leaf disks inoculated with tobacco mosaic virus (TMV).

Nani, Daniele
Brizzi, Maurizio
Lazzarato, Lisa
Betti, Lucietta
Publication Title: 

In this paper, we review three simple plant models (wheat seed germination, wheat seedling growth, and infected tobacco plants) that we set up during a series of experiments carried out from 1991 to 2009 in order to study the effects of homeopathic treatments. We will also describe the set of statistical tools applied in the different models. The homeopathic treatment used in our experiments was arsenic trioxide (As₂O₃) diluted in a decimal scale and dynamized.

Betti, Lucietta
Trebbi, Grazia
Zurla, Michela
Nani, Daniele
Peruzzi, Maurizio
Brizzi, Maurizio
Publication Title: 
Cancer Genomics & Proteomics

BACKGROUND: Arsenic trioxide (As(2)O(3)), a major compound in traditional Chinese medicine, is known to be an effective anticancer agent in acute promyelocytic leukemia (APL). The effects of As(2)O(3) on human hepatocellular carcinoma (HCC) SK-Hep-1 cells were studied employing proteomics-based methodologies. MATERIALS AND METHODS: Using 1-dimensional electrophoresis (1DE) and liquid chromatography electrospray ionization quadruple time-of-flight analysis, the whole proteomes of the control and As(2)O(3)-treated cells were profiled.

Yoo, Dong Ryeol
Chong, Seon Ah
Nam, Myeong Jin
Publication Title: 
Science (New York, N.Y.)

Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As2O3) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARalpha (a fusion protein containing sequences from the PML zinc finger protein and retinoic acid receptor alpha).

Zhang, Xiao-Wei
Yan, Xiao-Jing
Zhou, Zi-Ren
Yang, Fei-Fei
Wu, Zi-Yu
Sun, Hong-Bin
Liang, Wen-Xue
Song, Ai-Xin
Lallemand-Breitenbach, Valérie
Jeanne, Marion
Zhang, Qun-Ye
Yang, Huai-Yu
Huang, Qiu-Hua
Zhou, Guang-Biao
Tong, Jian-Hua
Zhang, Yan
Wu, Ji-Hui
Hu, Hong-Yu
de Thé, Hugues
Chen, Sai-Juan
Chen, Zhu
Publication Title: 
Cellular & Molecular Immunology

Asthma is one of the most common chronic airway inflammatory diseases. The clinical hallmarks of asthma include elevated serum levels of immunoglobulin E (IgE), eosinophilic inflammation and airway hyper-responsiveness (AHR). Arsenic trioxide (As2O3) is considered a carcinogen; however, it has also been used to treat diseases, such as syphilis, in traditional Chinese and Western medicine. Today, As2O3 is used as one of the standard therapies for acute promyelocytic leukemia (APL). Previous studies have indicated that As2O3 can induce apoptosis in eosinophils.

Chu, Kuan-Hua
Lee, Chen-Chen
Hsin, Shao-Chi
Cai, Bao-Chang
Wang, Jin-Hong
Chiang, Bor-Luen
Publication Title: 
Cancer Biology & Therapy

Arsenic trioxide (As(2)O(3)) is an active ingredient in traditional Chinese medicine. Recent studies showed that it causes apoptosis in several cancer cells. However, research of As(2)O(3) in osteosarcoma is sparse. In our present study, an inhibitory effect of As(2)O(3) on osteosarcoma cell adhesion and metastasis was observed with a cell adhesion, migration and invasion test. The impact of As(2)O(3) on the activities of MMP-9 and MAPK pathway-related downstream factors was analyzed by western blotting.

Tingting, Ren
Wei, Guo
Changliang, Peng
Xinchang, Lu
Yi, Yang
Publication Title: 
Iranian Journal of Allergy, Asthma, and Immunology

In traditional Chinese medicine, arsenous compounds, including arsenic trioxide (ATO), are often used to treat many diseases, which are safe and effective. Recently, studies have indicated that Th17- IL-17 involved in the pathogenesis and development of asthma. The goal of this study was to investigate the effect and mechanism of ATO on asthma, especially the Th17- IL-17 axis.We used oval bumin (OVA)-immunized mice as a model for asthma and treated mice with ATO or dexamethasone.

Zhang, Li
Li, Keng
Bing Ma, Li
Gong, Su-bo
Wang, Gu-yi
Liu, Yi
Ji, Xiao-ying
Xu, Li
Liu, Shao-kun
Chen, Ping
Ouyang, Ruo-yun
Xiang, Xu-dong
Publication Title: 
Chinese Medical Journal

BACKGROUND: The elevated matrix metalloproteinase (MMP) activity is an important cause of chronic wound healing failure. Arsenolite, whose main component is arsenic trioxide (As2O3), is a common traditional Chinese medicine wildly used in treating chronic wounds; it can remove necrotic tissue and promote tissue regeneration.

Liang, Ya-hui
Li, Ping
Zhao, Jing-xia
Dai, Miao-ke
Huang, Qi-Fu


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