Oxidopamine

Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Parkinsonism & Related Disorders

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M.

Author(s): 
Lieu, Christopher A.
Kunselman, Allen R.
Manyam, Bala V.
Venkiteswaran, Kala
Subramanian, Thyagarajan
Publication Title: 
Brain: A Journal of Neurology

The electrophysiological correlates of parkinsonism in the basal ganglia have been well studied in patients with Parkinson's disease and animal models. Separately, striatal dopaminergic cell transplantation has shown promise in ameliorating parkinsonian motor symptoms. However, the effect of dopaminergic grafts on basal ganglia electrophysiology has not thoroughly been investigated. In this study, we transplanted murine foetal ventral mesencephalic cells into rats rendered hemiparkinsonian by 6-hydroxydopamine injection.

Author(s): 
Gilmour, Timothy P.
Piallat, Brigitte
Lieu, Christopher A.
Venkiteswaran, Kala
Ramachandra, Renuka
Rao, Anand N.
Petticoffer, Andrew C.
Berk, Matthew A.
Subramanian, Thyagarajan
Publication Title: 
Brain Research Bulletin

Parkinson's disease (PD) is characterized by loss of nigrostriatal neurons and depletion of dopamine. This pathological feature leads to alterations to basal ganglia circuitry and subsequent motor disability. Pharmacological dopamine replacement therapy with medications such as levodopa ameliorates the symptoms of PD but can lead to motor complications known as drug-induced dyskinesias.

Author(s): 
Lieu, Christopher A.
Subramanian, Thyagarajan
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To explore the effect of traditional Chinese herbal medicine (TCM) for nourishing liver and kidney, clearing meridians and removing toxic substances, on the neurobehavioral manifestations and the activity of the dopamine D2 receptor in rat with levodopa-induced dyskinesias (LID). METHODS: The rat model of Parkinson's disease (PD) was established by injecting 6-hydroxydopamine (6-OHDA) into right substantia nigra of brain, then, the model of LID in rat was produced by injecting levodopa (LD) and benserazide for 4 weeks.

Author(s): 
Yuan, Can-Xing
Ye, Qing
Wang, Jie
Zhang, Yan
Yuan, Chong-Gang
Publication Title: 
Sheng Li Xue Bao: [Acta Physiologica Sinica]

The purpose of the present study is to observe the effect of electro-acupuncture (EA) stimulation on intracerebral neurotransmitters in a rat model of Parkinson's disease (PD), and explore the possible mechanism. We used 6-hydroxydopamine (6-OHDA) injection in medial forebrain bundle (MFB) in the right brain of Sprague Dawley (SD) rat to establish the parkinsonian rat model, and randomly divided the PD rats into model and 100 Hz EA stimulation groups (n =10 in each group).

Author(s): 
Du, Jing
Sun, Zuo-Li
Jia, Jun
Wang, Xuan
Wang, Xiao-Min
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