Ozone

Publication Title: 
American Journal of Epidemiology

Geographic variations in mortality rate in the United States could be due to several hypothesized factors, one of which is exposure to solar ultraviolet radiation (UVR). Limited evidence from previous prospective studies has been inconclusive. The association between ambient residential UVR exposure and total and cause-specific mortality risks in a regionally diverse cohort (346,615 white, non-Hispanic subjects, 50-71 years of age, in the National Institutes of Health (NIH)-AARP Diet and Health Study) was assessed, with accounting for individual-level confounders.

Author(s): 
Lin, Shih-Wen
Wheeler, David C.
Park, Yikyung
Spriggs, Michael
Hollenbeck, Albert R.
Freedman, D. Michal
Abnet, Christian C.
Publication Title: 
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia: 1952)
Author(s): 
Veldesi, F. A.
Publication Title: 
Toxicologic Pathology

Compared to healthy subjects, individuals with allergic airway disease (e.g., asthma, allergic rhinitis) have enhanced inflammatory responses to inhaled ozone. We created a rodent model of ozone-enhanced allergic nasal responses in Brown Norway rats to test the therapeutic effects of the dietary supplement gamma-tocopherol (gammaT). Ovalbumin (OVA)-sensitized rats were intranasally challenged with 0% or 0.5% OVA (in saline) on Days 1 and 2, and then exposed to 0 or 1 ppm ozone (eight hours/day) on Days 4 and 5.

Author(s): 
Wagner, James G.
Harkema, Jack R.
Jiang, Qing
Illek, Beate
Ames, Bruce N.
Peden, David B.
Publication Title: 
The Journal of Allergy and Clinical Immunology

BACKGROUND: The glutathione-S-transferase Mu 1 (GSTM1) null genotype has been reported to be a risk factor for acute respiratory disease associated with increases in ambient air ozone levels. Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known whether GSTM1 modulates these ozone responses in vivo in human subjects. OBJECTIVE: The purpose of this study was to determine whether the GSTM1 null genotype modulates ozone responses in human subjects.

Author(s): 
Alexis, Neil E.
Zhou, Haibo
Lay, John C.
Harris, Bradford
Hernandez, Michelle L.
Lu, Tsui-Shan
Bromberg, Philip A.
Diaz-Sanchez, David
Devlin, Robert B.
Kleeberger, Steven R.
Peden, David B.
Publication Title: 
The Journal of Allergy and Clinical Immunology

BACKGROUND: Asthma is a known risk factor for acute ozone-associated respiratory disease. Ozone causes an immediate decrease in lung function and increased airway inflammation. The role of atopy and asthma in modulation of ozone-induced inflammation has not been determined. OBJECTIVE: We sought to determine whether atopic status modulates ozone response phenotypes in human subjects. METHODS: Fifty volunteers (25 healthy volunteers, 14 atopic nonasthmatic subjects, and 11 atopic asthmatic subjects not requiring maintenance therapy) underwent a 0.4-ppm ozone exposure protocol.

Author(s): 
Hernandez, Michelle L.
Lay, John C.
Harris, Bradford
Esther, Charles R.
Brickey, W. June
Bromberg, Philip A.
Diaz-Sanchez, David
Devlin, Robert B.
Kleeberger, Steven R.
Alexis, Neil E.
Peden, David B.
Publication Title: 
Inhalation Toxicology

CONTEXT: Ozone exposure triggers airway inflammatory responses that may be influenced by biologically active purine metabolites. OBJECTIVE: To examine the relationships between airway purine metabolites and established inflammatory markers of ozone exposure, and to determine if these relationships are altered in individuals with atopy or asthma.

Author(s): 
Esther, Charles R.
Peden, David B.
Alexis, Neil E.
Hernandez, Michelle L.
Publication Title: 
Inhalation Toxicology

BACKGROUND: The evaluation of sputum leukocytes by flow cytometry (FCM) is an opportunity to assess characteristics of cells residing in the central airways, yet it is hampered by certain inherent properties of sputum including mucus and large amounts of contaminating cells and debris. OBJECTIVE: To develop a gating strategy based on specific antibody panels in combination with light scatter properties for flow cytometric evaluation of sputum cells. METHODS: Healthy and mild asthmatic volunteers underwent sputum induction.

Author(s): 
Lay, John C.
Peden, David B.
Alexis, Neil E.
Publication Title: 
Respiratory Research

BACKGROUND: The upper respiratory tract functions to protect lower respiratory structures from chemical and biological agents in inspired air. Cellular oxidative stress leading to acute and chronic inflammation contributes to the resultant pathology in many of these exposures and is typical of allergic disease, chronic sinusitis, pollutant exposure, and bacterial and viral infections. Little is known about the effective means by which topical treatment of the nose can strengthen its antioxidant and anti-inflammatory defenses.

Author(s): 
Gao, Meixia
Singh, Anju
Macri, Kristin
Reynolds, Curt
Singhal, Vandana
Biswal, Shyam
Spannhake, Ernst W.
Publication Title: 
Respiratory Research

BACKGROUND: Exposure to ozone activates innate immune function and causes neutrophilic (PMN) airway inflammation that in some individuals is robustly elevated. The interplay between immuno-inflammatory function and genomic signaling in those with heightened inflammatory responsiveness to ozone is not well understood. OBJECTIVES: Determine baseline predictors and post exposure discriminators for the immuno-inflammatory response to ozone in inflammatory responsive adult volunteers.

Author(s): 
Fry, Rebecca C.
Rager, Julia E.
Zhou, Haibo
Zou, Baiming
Brickey, June W.
Ting, Jenny
Lay, John C.
Peden, David B.
Alexis, Neil E.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: Homeopathic Pathogenetic Trials (HPTs) are a pillar of homeopathy, a key source of the symptoms characteristic of a particular homeopathic medicine. Homeopaths choose homeopathic medicines by comparing these remedy pictures with the symptoms the patient is presenting. Thus, recognition of these symptom sets underpins the clinical practice of homeopathy. OBJECTIVE: To test whether HPTs generate consistent and recognisable sets of symptoms in consecutive trials.

Author(s): 
Sherr, Jeremy
Quirk, Tina
Tournier, Alexander L.

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