P-Selectin

Publication Title: 
Platelets

Terminalia arjuna (TA) is a medicinal plant used as a cardiotonic in ayurveda. Besides others, scientific evidence dictates its strong hypolipidemic and antioxidant properties. However, anti-inflammatory and antiplatelet aggregatory properties of TA are not known. The present study demonstrates in vitro effects of its ethanolic bark extract (TAE) on platelet function indices. Twenty patients of angiographically proven coronary artery disease (CAD) were included in Group I and 20 age and sex-matched controls were included in Group II.

Author(s): 
Malik, Namita
Dhawan, Veena
Bahl, Ajay
Kaul, Deepak
Publication Title: 
International Journal of Oncology

Glycosylation of proteins plays multiple roles in cell-cell and cell-matrix interactions. Fucose is a monosaccharide associated with glycosylation events and is known to be over-expressed in many malignant tumors. By using alpha-L-fucosidase (alpha-L-fase), a glycosidase that specifically removes alpha-L-fucose (alpha-L-f), we have examined the potential effects of defucosylation on tumor functions, focusing on tumor progression in the context of the interaction of tumor cells with the extracellular microenvironment.

Author(s): 
Yuan, Kun
Kucik, Dennis
Singh, Raj K.
Listinsky, Catherine M.
Listinsky, Jay J.
Siegal, Gene P.
Publication Title: 
Metabolic Syndrome and Related Disorders

BACKGROUND: The Metabolic Syndrome (MS) confers an increased risk for diabetes and cardiovascular disease. We previously showed that simvastatin has concomitant benefits in reducing low-density lipoprotein (LDL)-cholesterol and inflammation in MS subjects. The levels of plasminogen activator inhibitor 1(PAI-1), soluble P-selectin (sP-selectin), and soluble CD40 ligand (sCD40L) play an important role in the development and progression of atherosclerosis. Their levels are increased in the MS.

Author(s): 
Wang, Long
Rockwood, Jason
Zak, Danielle
Devaraj, Sridevi
Jialal, Ishwarlal
Publication Title: 
Intensive Care Medicine

PURPOSE: Impaired microvascular perfusion in sepsis is not treated effectively because its mechanism is unknown. Since inflammatory and coagulation pathways cross-activate, we tested if stoppage of blood flow in septic capillaries is due to oxidant-dependent adhesion of platelets in these microvessels. METHODS: Sepsis was induced in wild type, eNOS(-/-), iNOS(-/-), and gp91phox(-/-) mice (n = 14-199) by injection of feces into the peritoneum. Platelet adhesion, fibrin deposition, and blood flow stoppage in capillaries of hindlimb skeletal muscle were assessed by intravital microscopy.

Author(s): 
Secor, Dan
Li, Fuyan
Ellis, Christopher G.
Sharpe, Michael D.
Gross, Peter L.
Wilson, John X.
Tyml, Karel
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: To investigate the ability of resolvin E1 (RvE1) to regulate adenosine diphosphate (ADP) activation of platelets via specific receptors because RvE1 reduces platelet aggregation with certain agonists, including ADP. METHODS AND RESULTS: RvE1 is an eicosapentaenoic acid-derived specialized proresolving mediator generated during the resolution of acute inflammation. RvE1 exhibits potent organ-protective actions in vivo and acts on specific cell types, including platelets.

Author(s): 
Fredman, Gabrielle
Van Dyke, Thomas E.
Serhan, Charles N.
Publication Title: 
Integrative Biology: Quantitative Biosciences from Nano to Macro

Model substrates presenting biochemical cues immobilized in a controlled and well-defined manner are of great interest for their applications in biointerface studies that elucidate the molecular basis of cell receptor-ligand interactions. Herein, we describe a direct, photochemical method to generate surface-immobilized biomolecular gradients that are applied to the study of selectin-mediated leukocyte rolling.

Author(s): 
Herman, Christine T.
Potts, Gregory K.
Michael, Madeline C.
Tolan, Nicole V.
Bailey, Ryan C.
Publication Title: 
PloS One

Stem bromelain, a cysteine protease isolated from pineapples, is a natural anti-inflammatory treatment, yet its mechanism of action remains unclear. Curious as to whether bromelain might affect selectin-mediated leukocyte rolling, we studied the ability of bromelain-treated human neutrophils to tether to substrates presenting immobilized P-selectin or E-selectin under shear stress. Bromelain treatment attenuated P-selectin-mediated tethering but had no effect on neutrophil recruitment on E-selectin substrates.

Author(s): 
Banks, Jessica M.
Herman, Christine T.
Bailey, Ryan C.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: To investigate the effects of the Traditional Chinese Medicine (TCM) Quyu Xiaoban capsules (QYXB) on clinical outcomes and platelet activation and aggregation in patients with unstable angina pectoris (UAP) and phlegm and blood stasis syndrome. DESIGN: Ninety patients with UAP were randomly divided into two groups: a control group that received a loading dose of 300 mg aspirin and a maintenance dose of 100 mg of aspirin plus baseline therapy for 4 weeks, and a trial group that received the same doses of aspirin and baseline therapy plus QYXB for 4 weeks.

Author(s): 
Liu, Yun Fang
Yu, Hui Ming
Zhang, Cheng
Yang, Rui Xue
Yan, Fang Fang
Liu, Yan
Zhang, Yun
Zhao, Yu Xia
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: To investigate the effects of the Traditional Chinese Medicine (TCM) Quyu Xiaoban capsules (QYXB) on clinical outcomes and platelet activation and aggregation in patients with unstable angina pectoris (UAP) and phlegm and blood stasis syndrome. DESIGN: Ninety (90) UAP patients were randomly divided into two groups: the control group received a loading dose of 300 mg aspirin and a maintenance dose of 100 mg of aspirin plus baseline therapy for 4 weeks, and the trial group received the same doses of aspirin and baseline therapy plus QYXB for 4 weeks.

Author(s): 
Liu, Yun Fang
Yu, Hui Ming
Zhang, Cheng
Yang, Rui Xue
Yan, Fang Fang
Liu, Yan
Zhang, Yun
Zhao, Yu Xia
Publication Title: 
World journal of gastroenterology: WJG

AIM: To investigate the effect of Danzhijiangtang capsule (DJC) on monocyte chemoattractant protein-1 (MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus (T2DM) subclinical vascular lesions. METHODS: Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a control group and treatment group of 31 cases each. Oral antidiabetic therapy with routine western medicine was conducted in both groups, and the treatment group was additionally treated with DJCs. The treatment course for both groups was 12 wk.

Author(s): 
Fang, Zhao-Hui
Liu, Yan
Bao, Tao-Tao
Ni, Ying-Qun
Liu, Jian
Shi, Guo-Bin
Wu, Ji-Ping
Yang, Jun-Ping
Zhang, Hong
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