Pain

Publication Title: 
Cancer Chemotherapy and Pharmacology

PURPOSE: Chemoneuropathy remains a painful, burdensome complication of cancer treatment for patients receiving a range of chemotherapeutics, yet the cause and persistence of this condition are not fully documented. This study was designed to quantify the longevity of and contributions to neuropathy following treatment with the plant alkaloids paclitaxel and vincristine.

Author(s): 
Boyette-Davis, Jessica A.
Cata, Juan P.
Driver, Larry C.
Novy, Diane M.
Bruel, Brian M.
Mooring, Deidre L.
Wendelschafer-Crabb, Gwen
Kennedy, William R.
Dougherty, Patrick M.
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Epigenetic regulation of gene expression is a rapidly growing area of research. Considering the longevity and plasticity of neurons, the studies on epigenetic pathways in the nervous system should be of special interest for both epigeneticists and neuroscientists. Activation or inactivation of different epigenetic pathways becomes more pronounced when the cells experience rapid changes in their environment, and such changes can be easily caused by injury and inflammation, resulting in pain perception or distortion of pain perception (eg, hyperalgesia).

Author(s): 
Seo, Seungmae
Grzenda, Adrienne
Lomberk, Gwen
Ou, Xiao-Ming
Cruciani, Ricardo A.
Urrutia, Raul
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Telomere length, considered a measure of biological aging, is linked to morbidity and mortality. Psychosocial factors associated with shortened telomeres are also common in chronic pain; yet, little is known about telomere length in pain populations. Leukocyte telomere length was evaluated in 66 women with fibromyalgia and 22 healthy female controls. Participants completed questionnaires and a subgroup of fibromyalgia patients underwent quantitative sensory testing (QST; n = 12) and neuroimaging (n = 12). Telomere length was measured using the quantitative polymerase chain reaction method.

Author(s): 
Hassett, Afton L.
Epel, Elissa
Clauw, Daniel J.
Harris, Richard E.
Harte, Steven E.
Kairys, Anson
Buyske, Steven
Williams, David A.
Publication Title: 
Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology

Recent human brain imaging studies have examined differences in activity in the nucleus accumbens (N.Acc.) in response to heat stimuli between controls and patients with chronic pain, and have revealed that the N.Acc. plays a role in predicting the value of a noxious stimulus and its offset, and in the consequent changes in the motivational state. Nevertheless, the molecular mechanisms of change in the circuitry involved in emotion and motivation in response to chronic pain stimuli were not fully explored.

Author(s): 
Ikegami, Daigo
Yamashita, Akira
Narita, Minoru
Publication Title: 
Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology

Genetic factors are involved in determinants for the risk of psychiatric disorders, and neurological and neurodegenerative diseases. Chronic pain stimuli and intense pain have effects at a cellular and/or gene expression level, and will eventually induce "cellular memory due to pain", which means that tissue damage, even if only transient, can elicit epigenetically abnormal transcription/translation and post-translational modification in related cells depending on the degree or kind of injury or associated conditions.

Author(s): 
Narita, Minoru
Watanabe, Moe
Hamada, Yusuke
Tamura, Hideki
Ikegami, Daigo
Kuzumaki, Naoko
Igarashi, Katsuhide
Publication Title: 
Christian Bioethics

Drawing chiefly on recent sources, in Part One I sketch an untraditional way of articulating what I claim to be central elements of traditional Catholic morality, treating it as based in virtues, focused on the recipients ("patients") of our attention and concern, and centered in certain person-to-person role-relationships. I show the limited and derivative places of "natural law," and therefore of sin, within that framework.

Author(s): 
Garcia, J. L. A.
Publication Title: 
International Journal of Obesity

An understanding of the possible psychologic impediments to weight loss can promote improved therapeutic intervention for the obese patient. Certain psychological tasks are imposed by chronic medical illness including obesity. The universal stresses that accompany medical illness, the basic threat to self-esteem and sense of intactness, the fear--of loss of love and approval, of loss of control of function, of injury to body parts, of pain, and of guilt--all become psychological impediments thwarting weight loss and its maintenance.

Author(s): 
Strain, G. W.
Strain, J. J.
Publication Title: 
Ethics & Behavior

Religious traditions can be drawn on in a number of ways to illuminate discussions of the moral standing of animals and the ethical use of animals in scientific research. I begin with some general comments about relevant points in the history of major religions. I then briefly describe American civil religion, including the cult of health, and its relation to scientific research. Finally, I offer a critique of American civil religion from a Christian perspective.

Author(s): 
Smith, David H.
Publication Title: 
Journal of Advanced Nursing

Spirituality is an important though often neglected aspect of pain in patients with human immunodeficiency virus (HIV) and/or cancer, for both patients and nurses. The spiritual domain involves: (1) meaning, (2) hope and (3) love and relatedness. The author examines spiritual aspects of pain in persons with HIV and/or cancer, as supported by the literature. Understanding spiritual aspects of pain carries implications for nursing. One of these implications is that it is important for the nurse to be closer to his/her own spirit in order to be there for the patient in pain.

Author(s): 
Newshan, G.
Publication Title: 
Christian Bioethics

The historic or traditional Christian view of pain (suffering) and death, especially as preserved by the Christians East (i.e., the Orthodox), is radically opposed to the modern secular obsession with avoidance of pain. Everything about this life has its goal or aim in a mystical reality, the Kingdom of Heaven, for which earthly life is a preparation. While neither illness nor health are seen as ends in themselves, both are viewed as proceeding from the will of God for our benefit and have no ultimate meaning or purpose outside of eternal life.

Author(s): 
Young, Alexey

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