Panax

Publication Title: 
Acta Pharmacologica Sinica

Trilinolein is a triacylglycerol purified from a commonly used traditional Chinese medicine Panax notoginseng. Trilinolein has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. Additionally, trilinolein has been reported to be an antioxidant, which can counteract free radical damage associated with atherogenesis, and myocardial damage seen with ischaemia and reperfusion.

Author(s): 
Chan, Paul
Thomas, G. Neil
Tomlinson, Brian
Publication Title: 
Hypertension Research: Official Journal of the Japanese Society of Hypertension

Insulin resistance and hyperinsulinemia are common findings in patients with essential hypertension. These impairments in glucose metabolism are commonly associated with diabetes mellitus, hypertension, and dyslipidemia, which are high risk factors of cardiovascular diseases, and recent evidence indicates that they may play a role in the development of coronary artery disease.

Author(s): 
Wang, Ling
Higashiura, Katsuhiro
Ura, Nobuyuki
Miura, Tetsuji
Shimamoto, Kazuaki
Publication Title: 
Acta Pharmacologica Sinica

The main objective of this paper is to review the chemical and genetic methods used in authentication of ginseng, especially the recent advances in microsatellite genotyping and its application to the authentication of other traditional Chinese medicines (TCM). The standardization and modernization of TCM hinge on the authentication of their botanical identities. Analysis of well-characterized marker compounds is now the most popular method for identifying the herbal materials and quality control of TCM, eg, ginsenoside profiling for authentication of Panax species.

Author(s): 
Hon, C. C.
Chow, Y. C.
Zeng, F. Y.
Leung, F. C. C.
Publication Title: 
Journal of Pharmacological Sciences

We are exposed to many external and internal stresses in this day and age. Stress weakens the function of immune systems in living organisms and disturbs homeostasis. As a result, stress induces various psychosomatic diseases. Thus, ways of reducing stress and thus protecting humans from disease must be developed. One such method is called "the prevention of Mibyou" in Kampo, the Chinese traditional medicine. Many studies have reported the direct effects of medical ginseng on damaged target organs and recovery from disease.

Author(s): 
Kaneko, Hitoshi
Nakanishi, Kozo
Publication Title: 
Mutagenesis

A majority of potential radioprotective synthetic compounds have demonstrated limited clinical application owing to their inherent toxicity, and thus, the seeking of naturally occurring herbal products, such as ginseng, for their radioprotective capability has become an attractive alternative. In general, ginseng refers to the roots of the species of the genus Panax. As a medicinal herb, ginseng has been widely used in traditional Chinese medicine for its wide spectrum of medicinal effects, such as tonic, immunomodulatory, antimutagenic, adaptogenic and antiaging activities.

Author(s): 
Lee, Tung-Kwang
Johnke, Roberta M.
Allison, Ron R.
O'Brien, Kevin F.
Dobbs, Larry J.
Publication Title: 
Endocrine, Metabolic & Immune Disorders Drug Targets

In management of metabolic syndrome, the traditional Chinese medicine (TCM) is an excellent representative in alternative and complementary medicines with a complete theory system and substantial herb remedies. In this article, basic principle of TCM is introduced and 25 traditional Chinese herbs are reviewed for their potential activities in the treatment of metabolic syndrome. Three herbs, ginseng, rhizoma coptidis (berberine, the major active compound) and bitter melon, were discussed in detail on their therapeutic potentials.

Author(s): 
Yin, Jun
Zhang, Hanjie
Ye, Jianping
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

Abstract Traditional Chinese Medicine (TCM) is one of the oldest forms of medicine in the world. There has been a growing interest in TCM in Canada in terms of consumers and also among the research community. To cater for this interest, the Canadian Institute of Chinese Medicinal Research (CICMR) was established in 2004. Since its formation, CICMR has been organizing annual meetings. In 2008, the CICMR meeting, jointly organized with the Ontario Ginseng Innovation Research Centre, was held from October 16th to 19th, in London, Ontario, Canada.

Author(s): 
Ghayur, Muhammad Nabeel
Publication Title: 
Current Medicinal Chemistry

The dawning of this millennium broke new ground in life science and technology, presented us genomic and proteomic revolution, nanotechnology innovation, and high performance liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) used for separating and identifying new chemical entities at pico-, or even femto-concentrations. Applications of these high technologies to the traditional Chinese medicine (TCM) opened a new chapter in the ancient medicine, and prompted us to re-evaluate the thousand-year-old phytomedicine- ginseng from current perspectives.

Author(s): 
Jia, Lee
Zhao, Yuqing
Publication Title: 
Current Medicinal Chemistry

This review, a sequel to part 1 in the series, collects about 107 chemical entities separated from the roots, leaves and flower buds of Panax ginseng, quinquefolius and notoginseng, and categorizes these entities into about 18 groups based on their structural similarity. The bioactivities of these chemical entities are described.

Author(s): 
Jia, Lee
Zhao, Yuqing
Liang, Xing-Jie
Publication Title: 
The Journal of Veterinary Medical Science / the Japanese Society of Veterinary Science

It is well known that maintenance therapy using Chai-hu-gui-zhi-tang (CHGZT), a traditional Chinese medicine, has been proven to prevent the recurrence of peptic ulcers. However, little is known as to whether or not it has protective effects against acute gastric injury. In the present study, we investigated the preventive effects of pretreatment with CHGZT extract on the development of water immersion restraint stress-induced acute gastric ulceration in male Wistar rats.

Author(s): 
Chen, Chi-Yang
Kuo, Tsung-Li
Sheu, Shi-Yuan
Kuo, Tzong-Fu

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