Pancreas

Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

In investigating the role of metal ions in the pathogenesis of Huntington's disease, we examined the effects of clioquinol, a metal-binding compound currently in clinical trials for Alzheimer's disease treatment, on mutant huntingtin-expressing cells. We found that PC12 cells expressing polyglutamine-expanded huntingtin exon 1 accumulated less mutant protein and showed decreased cell death when treated with clioquinol. This effect was polyglutamine-length-specific and did not alter mRNA levels or protein degradation rates.

Author(s): 
Nguyen, Trent
Hamby, Aaron
Massa, Stephen M.
Publication Title: 
Journal of the American Dietetic Association

Cystic fibrosis (CF) is an autosomal recessive disease characterized clinically by recurrent respiratory tract infections and malabsorption caused by pancreatic insufficiency. Typically diagnosed during infancy or childhood, CF impairs weight gain and growth, increases susceptibility to infection, and decreases longevity. Until recently, no guidelines for infant feedings were available. A consensus report prepared through the Cystic Fibrosis Foundation summarizes guidelines for the optimal nutrition management of patients with CF.

Author(s): 
Cannella, P. C.
Bowser, E. K.
Guyer, L. K.
Borum, P. R.
Publication Title: 
Scientific Reports

Sirt1 is an NAD(+)-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet.

Author(s): 
Minor, Robin K.
Baur, Joseph A.
Gomes, Ana P.
Ward, Theresa M.
Csiszar, Anna
Mercken, Evi M.
Abdelmohsen, Kotb
Shin, Yu-Kyong
Cantó, Carles
Scheibye-Knudsen, Morten
Krawczyk, Melissa
Irusta, Pablo M.
Martin-Montalvo, Alejandro
Hubbard, Basil P.
Zhang, Yongqing
Lehrmann, Elin
White, Alexa A.
Price, Nathan L.
Swindell, William R.
Pearson, Kevin J.
Becker, Kevin G.
Bohr, Vilhelm A.
Gorospe, Myriam
Egan, Josephine M.
Talan, Mark I.
Auwerx, Johan
Westphal, Christoph H.
Ellis, James L.
Ungvari, Zoltan
Vlasuk, George P.
Elliott, Peter J.
Sinclair, David A.
de Cabo, Rafael
Publication Title: 
International Journal of Experimental Diabetes Research

Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times. Embelia ribes burm (Myrsinaceae), known commonly as vidanga, was used in Ayurveda for its anthelmintic activity. Ayurveda describes vidanga as pungent, causes increase in digestive fire, and cures flatulence and colic. A single study reported the antihyperglycemic activity of decoction of E. ribes in glucose-induced hyperglycemic albino rabbits. In the present study, the lipid-lowering and antioxidant potential of ethanolic extract of E.

Author(s): 
Bhandari, Uma
Kanojia, Raman
Pillai, K. K.
Publication Title: 
BMC cancer

BACKGROUND: Triphala is commonly used in Ayurvedic medicine to treat variety of diseases; however its mechanism of action remains unexplored. This study elucidates the molecular mechanism of Triphala against human pancreatic cancer in the cellular and in vivo model. METHODS: Growth-inhibitory effects of Triphala were evaluated in Capan-2, BxPC-3 and HPDE-6 cells by Sulphoradamine-B assay. Apoptosis was determined by cell death assay and western blotting. Triphala was administered orally to nude mice implanted with Capan-2 xenograft.

Author(s): 
Shi, Yan
Sahu, Ravi P.
Srivastava, Sanjay K.
Publication Title: 
International Journal of Experimental Diabetes Research

Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times. Embelia ribes burm (Myrsinaceae), known commonly as vidanga, was used in Ayurveda for its anthelmintic activity. Ayurveda describes vidanga as pungent, causes increase in digestive fire, and cures flatulence and colic. A single study reported the antihyperglycemic activity of decoction of E. ribes in glucose-induced hyperglycemic albino rabbits. In the present study, the lipid-lowering and antioxidant potential of ethanolic extract of E.

Author(s): 
Bhandari, Uma
Kanojia, Raman
Pillai, K. K.
Publication Title: 
BMC cancer

BACKGROUND: Triphala is commonly used in Ayurvedic medicine to treat variety of diseases; however its mechanism of action remains unexplored. This study elucidates the molecular mechanism of Triphala against human pancreatic cancer in the cellular and in vivo model. METHODS: Growth-inhibitory effects of Triphala were evaluated in Capan-2, BxPC-3 and HPDE-6 cells by Sulphoradamine-B assay. Apoptosis was determined by cell death assay and western blotting. Triphala was administered orally to nude mice implanted with Capan-2 xenograft.

Author(s): 
Shi, Yan
Sahu, Ravi P.
Srivastava, Sanjay K.
Publication Title: 
Phytotherapy research: PTR

Curcuma longa (turmeric) has been used widely as a spice, particularly in Asian countries. It is also used in the Ayurvedic system of medicine as an antiinflammatory and antimicrobial agent and for numerous other curative properties. The aim of this study was to investigate the effects of an aqueous extract of Curcuma longa (AEC) on tissues involved in glucose homeostasis. The extract was prepared by soaking 100 g of ground turmeric in 1 L of water, which was filtered and stored at -20°C prior to use.

Author(s): 
Mohankumar, Sureshkumar
McFarlane, James R.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Pterocarpus marsupium Roxb. (PM) is an Ayurvedic traditional medicine well known for its antidiabetic potential. AIM: To fractionate the antidiabetic constituent(s) of the aqueous of extract of PM hardwood (PME). MATERIALS AND METHODS: Bio-assay methods including, insulin secretion from mouse pancreas and glucose uptake by mouse skeletal muscle, were used to determine and fractionate the antidiabetic activity of PME.

Author(s): 
Mohankumar, Suresh K.
O'Shea, Tim
McFarlane, James R.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Ficus amplissima commonly known as kal-itchchi have a long history of use in Ayurveda, Siddha and Unani herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes. AIM: The aim of the present study was to evaluate the effect of methanolic extract of the bark of Ficus amplissima (FAB) in streptozotocin-induced diabetic rats.

Author(s): 
Arunachalam, Karuppusamy
Parimelazhagan, Thangaraj

Pages

Subscribe to RSS - Pancreas