Pancreatic Neoplasms

Publication Title: 
Nature Reviews. Gastroenterology & Hepatology

Pancreatic cancer, although infrequent, has an exceptionally high mortality rate, making it one of the four or five most common causes of cancer mortality in developed countries. The incidence of pancreatic cancer varies greatly across regions, which suggests roles for lifestyle factors, such as diet, or environmental factors, such as vitamin D exposure. Smoking is the most common known risk factor, and is the cause of 20-25% of all pancreatic tumors. Alcohol does not seem to be a risk factor, unless it leads to chronic pancreatitis, which is a probable risk factor.

Raimondi, Sara
Maisonneuve, Patrick
Lowenfels, Albert B.
Publication Title: 
Digestive Diseases (Basel, Switzerland)

Pancreatic cancer, although infrequent, has a very poor prognosis, making it one of the 4 or 5 most common causes of cancer mortality in developed countries. Its incidence varies greatly across regions, which suggests that lifestyle factors such as diet, and environmental factors, such as vitamin D exposure, play a role. Because pancreatic cancer is strongly age-dependent, increasing population longevity and ageing will lead to an increase of the global burden of pancreatic cancer in the coming decades. Smoking is the most common known risk factor, causing 20-25% of all pancreatic tumors.

Maisonneuve, Patrick
Lowenfels, Albert B.
Publication Title: 
Journal of Health Care Chaplaincy

Chaplains serving in the health care context provide a ministry to dying patients of inestimable worth as they comfort patients in the last chapter of the journey by being present, listening, and caring. Chaplains also play another important role, helping patients clarify ways in which their beliefs and values might influence health care decisions. This paper reviewed the current trends of spiritual diversity alongside the aging of a large Baby Boomer cohort.

Ai, Amy L.
McCormick, Thomas R.
Publication Title: 
Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.]

Regardless of the treatment regimens and ongoing research we do as medical doctors and scientists, our bottom line is to improve the lives of those suffering from pancreatic cancer; certainly not an easy undertaking. In a previous issue of Pancreatology (April 2008, vol. 8), our editor discussed the importance of empathy toward our patients. In reflecting on the mission of trying to accomplish this goal, it is the patients, themselves, and their families who can offer the best insight into the quality of life of the patient.

Lomberk, Gwen
Publication Title: 
Journal of Registry Management

Cancer registries play a vital role in research, as they provide important data that can be used to assess disease etiology and risk. Specialty registries can help to address the need for information on defined cancer types. However, achieving high rates of participation in such registries is problematic.We studied the impact of decision support on patient participation in a hospital-based pancreas cancer registry, the Jefferson Pancreas Tumor Registry (JPTR).

Myers, Ronald
Lavu, Harish
Keith, Scott W.
Kelly, Heidi
O'Rourke, Nadine
Cocroft, James
Quinn, Anna
Potluri, Vishnu
Yeo, Charles J.
Publication Title: 
Cancer Chemotherapy and Pharmacology

Pancreatic cancer is highly resistant to the currently available chemotherapeutic agents. Less than 5% of patients diagnosed with this disease could survive beyond 5 years. Thus, there is an urgent need for the development of novel, efficacious drugs that can treat pancreatic cancer. Herein we report the identification of artesunate (ART), a derivative of artemisinin, as a potent and selective antitumor agent against human pancreatic cancer cells in vitro and in vivo.

Du, Ji-Hui
Zhang, Hou-De
Ma, Zhen-Jian
Ji, Kun-Mei
Publication Title: 
PloS One

BACKGROUND: Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown antitumor activity in various cancer cells. Apo2 ligand or tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is regarded as a promising anticancer agent, but chemoresistance affects its efficacy as a treatment strategy. Apoptosis induced by the combination of DHA and Apo2L/TRAIL has not been well documented, and the mechanisms involved remain unclear.

Kong, Rui
Jia, Guang
Cheng, Zhuo-xin
Wang, Yong-wei
Mu, Ming
Wang, Shuang-jia
Pan, Shang-ha
Gao, Yue
Jiang, Hong-chi
Dong, De-li
Sun, Bei
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: Pancreatic cancer is the fourth cause of death from cancer in the western world. Majority of patients present with advanced unresectable disease responding poorly to most chemotherapeutic agents. Chemotherapy for pancreatic cancer might be improved by adjusting it to individual genetic profiles. We attempt to identify genetic predictors of chemosensitivity to broad classes of anticancer drugs.

Cui, Yunfeng
Brosnan, Jacqueline A.
Blackford, Amanda L.
Sur, Surojit
Hruban, Ralph H.
Kinzler, Kenneth W.
Vogelstein, Bert
Maitra, Anirban
Diaz, Luis A.
Iacobuzio-Donahue, Christine A.
Eshleman, James R.
Publication Title: 
BMC cancer

BACKGROUND: Triphala is commonly used in Ayurvedic medicine to treat variety of diseases; however its mechanism of action remains unexplored. This study elucidates the molecular mechanism of Triphala against human pancreatic cancer in the cellular and in vivo model. METHODS: Growth-inhibitory effects of Triphala were evaluated in Capan-2, BxPC-3 and HPDE-6 cells by Sulphoradamine-B assay. Apoptosis was determined by cell death assay and western blotting. Triphala was administered orally to nude mice implanted with Capan-2 xenograft.

Shi, Yan
Sahu, Ravi P.
Srivastava, Sanjay K.
Publication Title: 
PloS One

Pancreatic cancer (PaCa) is one of the most lethal cancers, with an estimated 5-year survival of <5% even when patients are given the best treatment available. In addition, these treatments are often toxic and expensive, thus new agents which are safe, affordable and effective are urgently needed. We describe here the results of our study with acetyl-11-keto-β-boswellic acid (AKBA), an agent obtained from an Ayurvedic medicine, gum resin of Boswellia serrata. Whether AKBA has an activity against human PaCa, was examined in in vitro models and in an orthotopic nude mouse model of PaCa.

Park, Byoungduck
Prasad, Sahdeo
Yadav, Vivek
Sung, Bokyung
Aggarwal, Bharat B.


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