Papillomaviridae

Publication Title: 
Oncogene

This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at which normal cells become senescent. In the second phase (immortalization), the cells activate a telomere maintenance mechanism and acquire an unlimited proliferative potential.

Author(s): 
Noble, J. R.
Rogan, E. M.
Neumann, A. A.
Maclean, K.
Bryan, T. M.
Reddel, R. R.
Publication Title: 
Oncogene

Cell cycle checkpoints and tumor suppressor gene functions appear to be required for the maintenance of a stable genome in proliferating cells. In this study chromosomal destabilization was monitored in relation to telomere structure, lifespan control and G2 checkpoint function. Replicative senescence was inactivated in secondary cultures of human skin fibroblasts by expressing the human papillomavirus type 16 (HPV-16) E6 oncoprotein to inactivate p53. Chromosome aberrations were enumerated during in vitro aging of isogenic control (F5neo) and HPV-16E6-expressing (F5E6) fibroblasts.

Author(s): 
Filatov, L.
Golubovskaya, V.
Hurt, J. C.
Byrd, L. L.
Phillips, J. M.
Kaufmann, W. K.
Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Transfection of nearly senesced human fibroblasts with plasmids encoding HPV16 E6 protein or dominant-negative p53 mutants greatly increased their colony-forming ability. Isolated colonies with these plasmids showed extension of lifespan compared to those with a control plasmid. These data demonstrate that p53 plays a major role in senescence in normal human fibroblasts.

Author(s): 
Ide, A.
Fujii, M.
Nakababashi, K.
Ayusawa, D.
Publication Title: 
Cancer Research

Nearly all cervical cancers are etiologically attributable to human papillomavirus (HPV) infection and pharmaceutical treatments targeting HPV-infected cells would be of great medical benefit. Because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating HPV-infected or transformed cells.

Author(s): 
Disbrow, Gary L.
Baege, Astrid C.
Kierpiec, Katie A.
Yuan, Hang
Centeno, Jose A.
Thibodeaux, Clare A.
Hartmann, Dan
Schlegel, Richard
Publication Title: 
Cancer Research

Nearly all cervical cancers are etiologically attributable to human papillomavirus (HPV) infection and pharmaceutical treatments targeting HPV-infected cells would be of great medical benefit. Because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating HPV-infected or transformed cells.

Author(s): 
Disbrow, Gary L.
Baege, Astrid C.
Kierpiec, Katie A.
Yuan, Hang
Centeno, Jose A.
Thibodeaux, Clare A.
Hartmann, Dan
Schlegel, Richard
Publication Title: 
Human Vaccines

Successful implementation of Human Papillomavirus (HPV) vaccine in each country can only be achieved from a complementary and synergistic perspective, integrating all the different points of view of the diverse related professionals. It is this context where the Spanish HPV Vaccine Consensus Group (Grupo Español de Consenso sobre la Vacuna VPH, GEC-VPH) was created. GEC-VPH philosophy, objectives and experience are reported in this article, with particular attention to the management of negative publicity and anti-vaccine groups.

Author(s): 
Cortés-Bordoy, Javier
Martinón-Torres, Federico
Spanish HPV Vaccine Consensus Group
Publication Title: 
Human Vaccines

Successful implementation of Human Papillomavirus (HPV) vaccine in each country can only be achieved from a complementary and synergistic perspective, integrating all the different points of view of the diverse related professionals. It is this context where the Spanish HPV Vaccine Consensus Group (Grupo Español de Consenso sobre la Vacuna VPH, GEC-VPH) was created. GEC-VPH philosophy, objectives and experience are reported in this article, with particular attention to the management of negative publicity and anti-vaccine groups.

Author(s): 
Cortés-Bordoy, Javier
Martinón-Torres, Federico
Spanish HPV Vaccine Consensus Group
Publication Title: 
Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

Research from the past several years has definitively shown intermediate and high risk-type human papillomavirus (HPV) infection to play a significant role in cervical carcinogenesis. Persistent compared with intermittent infection appears to confer an elevated risk, and cofactors may be necessary to allow the virus to progress to cervical cancer.

Author(s): 
Giuliano, A. R.
Papenfuss, M.
Nour, M.
Canfield, L. M.
Schneider, A.
Hatch, K.
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