Pharmaceutical Preparations

Publication Title: 
BMC geriatrics

BACKGROUND: Pharmacotherapy in the older adult is a complex field involving several different medical professionals. The evidence base for pharmacotherapy in elderly patients in primary care relies on only a few clinical trials, thus documentation must be improved, particularly in the field of complementary and alternative medicine (CAM) like phytotherapy, homoeopathy, and anthroposophic medicine. This study describes diagnoses and therapies observed in elderly patients treated with anthroposophic medicine in usual care.

Author(s): 
Jeschke, Elke
Ostermann, Thomas
Tabali, Manuela
Vollmar, Horst C.
Kröz, Matthias
Bockelbrink, Angelina
Witt, Claudia M.
Willich, Stefan N.
Matthes, Harald
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: A review of Hahnemann's clinical records at the Institute for History of Medicine of the Robert Bosch Foundation in Stuttgart shows that until the end of his life, Hahnemann continued to refine his clinical method, based on clinical cases. His "most perfected method" motivated him to write the sixth edition of the The Organon of the Healing Art, proposing solutions controlling the side effects he observed with repeated doses of homeopathic medicines. Unfortunately, this was published many years posthumously.

Author(s): 
Adler, U. C.
Adler, M. S.
Publication Title: 
Pharmacoepidemiology and Drug Safety

PURPOSE: The socioeconomic determinants for drug utilization, especially in children, have not been investigated sufficiently so far. The study's aim was the estimation of prevalences and determinants of conventional, homeopathic and phytotherapeutic drugs and expenditures. METHODS: Population-based data on drug utilization of 3,642 children in two German birth cohorts (GINIplus and LISAplus, 10-year follow-up) were collected using a self-administered questionnaire.

Author(s): 
Italia, Salvatore
Batscheider, Ariane
Heinrich, Joachim
Wenig, Christina
Bauer, Carl Peter
Koletzko, Sibylle
Lehmann, Irina
Herbarth, Olf
von Berg, Andrea
Berdel, Dietrich
Hoffmann, Barbara
Schaaf, Beate
Wolfenstetter, Silke B.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Shilajit is a multi-component natural occurring mineral substance used in Ayurveda and Siddha systems of medicine which originated in India. Its source can be traced to the mountainous regions, where the hilly tribes first identified its beneficial use. Shilajit is aptly referred to as 'rasayana'/'rasayanam' in Ayurveda and Siddha literature which means rejuvenator because it prevents ailment and enhances the quality of life.

Author(s): 
Wilson, Eugene
Rajamanickam, G. Victor
Dubey, G. Prasad
Klose, Petra
Musial, Frauke
Saha, F. Joyonto
Rampp, Thomas
Michalsen, Andreas
Dobos, Gustav J.
Publication Title: 
Gerontology

Aging is characterized by a progressive decline of cellular functions. The aging liver appears to preserve its function relatively well. Aging is associated in human liver with morphological changes such as decrease in size attributable to decreased hepatic blood flow. Ultrastructural analysis of the human liver has revealed that the integrity of mitochondria and enzymatic activity remain mostly unchanged with aging. Reactive oxygen species (ROS) are involved in the aging process and result mainly from nonenzymatic processes in the liver.

Author(s): 
Anantharaju, Abhinandana
Feller, Axel
Chedid, Antonio
Publication Title: 
Translational Research: The Journal of Laboratory and Clinical Medicine

Silent information regulator 2 (Sir2/Sirt1), a member of the sirtuin family of class III histone deacetylases, has been implicated extensively in lifespan extension and is a prominent drug target in antiaging medicine. The mammalian Sirt1 has multiple targets, which include histones, transcription factors, and other molecules that collectively modulate energy metabolism, stress response, and cell/tissue survival. Several of Sirt1's substrates regulate key metabolic processes, and Sirt1 activation may underlie the lifespan prolonging effect of caloric restriction.

Author(s): 
Tang, Bor Luen
Publication Title: 
The AAPS journal

Liposomes, phospholipid vesicles with a bilayered membrane structure, have been widely used as pharmaceutical carriers for drugs and genes, in particular for treatment of cancer.

Author(s): 
Sawant, Rupa R.
Torchilin, Vladimir P.
Publication Title: 
Gerontology

Aging is characterized by a progressive decline of cellular functions. The aging liver appears to preserve its function relatively well. Aging is associated in human liver with morphological changes such as decrease in size attributable to decreased hepatic blood flow. Ultrastructural analysis of the human liver has revealed that the integrity of mitochondria and enzymatic activity remain mostly unchanged with aging. Reactive oxygen species (ROS) are involved in the aging process and result mainly from nonenzymatic processes in the liver.

Author(s): 
Anantharaju, Abhinandana
Feller, Axel
Chedid, Antonio
Publication Title: 
The Keio Journal of Medicine

Rapid progress is being made in our ability to modify the aging process. Rather than serving as a period of debility and decreasing health, for many people, the later years of life are becoming a period of continued productivity, independence and good health. Progress is also being made in increasing average lifespan. The leading causes of death (cardiovascular disease, cancer, lung disease, diabetes) are the end result of decades-long processes. With current knowledge, it is possible to delay the onset of these diseases.

Author(s): 
Grossman, Terry
Publication Title: 
Current Drug Targets

A significant increase of the elderly in populations of developed countries is followed by increase morbidity and mortality from main age-related diseases--cardiovascular and neuro-degenerative, cancer, diabetes mellitus, declining in a resistance to infections. Obviously, the development of means of the prevention of the premature ageing and these diseases in humans are crucial at present.

Author(s): 
Anisimov, Vladimir N.

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