Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

The putative oxidation of hydroethidine (HE) has become a widely used fluorescent assay for the detection of superoxide in cultured cells. By covalently joining HE to a hexyl triphenylphosphonium cation (Mito-HE), the HE moiety can be targeted to mitochondria. However, the specificity of HE and Mito-HE for superoxide in vivo is limited by autooxidation as well as by nonsuperoxide-dependent cellular processes that can oxidize HE probes to ethidium (Etd).

Robinson, Kristine M.
Janes, Michael S.
Pehar, Mariana
Monette, Jeffrey S.
Ross, Meredith F.
Hagen, Tory M.
Murphy, Michael P.
Beckman, Joseph S.
Publication Title: 
Developmental Neuroscience

Characterization of the ontogeny of the cerebral dopaminergic system is crucial for gaining a greater understanding of normal brain development and its alterations in response to drugs of abuse or conditions such as attention-deficit hyperactivity disorder. Pharmacological MRI (phMRI) was used to determine the response to dopamine transporter (DAT) blockers cocaine and methylphenidate (MPH), the dopamine releaser D-amphetamine (AMPH), the selective D1 agonist dihydrexidine, and the D2/D3 agonist quinpirole in young (<30 days old) and adult (>60 days old) rats.

Chen, Y. Iris
Choi, Ji-Kyung
Xu, Haibo
Ren, JiaQian
Andersen, Susan L.
Jenkins, Bruce G.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

There is increasing evidence that age-associated chronic low-grade inflammation promotes the development of both large-vessel disease (myocardial infarction, stroke, peripheral arterial disease) and small-vessel pathologies (including vascular cognitive impairment) in older persons. However, the source of age-related chronic vascular inflammation remains unclear.

Csiszar, Anna
Sosnowska, Danuta
Wang, Mingyi
Lakatta, Edward G.
Sonntag, William E.
Ungvari, Zoltan
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