Phenanthridines

Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

The putative oxidation of hydroethidine (HE) has become a widely used fluorescent assay for the detection of superoxide in cultured cells. By covalently joining HE to a hexyl triphenylphosphonium cation (Mito-HE), the HE moiety can be targeted to mitochondria. However, the specificity of HE and Mito-HE for superoxide in vivo is limited by autooxidation as well as by nonsuperoxide-dependent cellular processes that can oxidize HE probes to ethidium (Etd).

Author(s): 
Robinson, Kristine M.
Janes, Michael S.
Pehar, Mariana
Monette, Jeffrey S.
Ross, Meredith F.
Hagen, Tory M.
Murphy, Michael P.
Beckman, Joseph S.
Publication Title: 
Developmental Neuroscience

Characterization of the ontogeny of the cerebral dopaminergic system is crucial for gaining a greater understanding of normal brain development and its alterations in response to drugs of abuse or conditions such as attention-deficit hyperactivity disorder. Pharmacological MRI (phMRI) was used to determine the response to dopamine transporter (DAT) blockers cocaine and methylphenidate (MPH), the dopamine releaser D-amphetamine (AMPH), the selective D1 agonist dihydrexidine, and the D2/D3 agonist quinpirole in young (<30 days old) and adult (>60 days old) rats.

Author(s): 
Chen, Y. Iris
Choi, Ji-Kyung
Xu, Haibo
Ren, JiaQian
Andersen, Susan L.
Jenkins, Bruce G.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

There is increasing evidence that age-associated chronic low-grade inflammation promotes the development of both large-vessel disease (myocardial infarction, stroke, peripheral arterial disease) and small-vessel pathologies (including vascular cognitive impairment) in older persons. However, the source of age-related chronic vascular inflammation remains unclear.

Author(s): 
Csiszar, Anna
Sosnowska, Danuta
Wang, Mingyi
Lakatta, Edward G.
Sonntag, William E.
Ungvari, Zoltan
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