Phosphates

Publication Title: 
Postgraduate Medicine

Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for cardiovascular events and mortality. Calcification of the arterial media and of heart valves clearly plays a mediating role in this regard, whereas it is less clear how calcification of plaque influences atherogenesis and risk for plaque rupture. Vascular calcification is an active process in which vascular smooth muscle cells (VSMCs) adopt an osteoblastic phenotype and deposit hydroxyapatite crystals; apoptosis of VSMCs also promotes this deposition.

Author(s): 
McCarty, Mark F.
DiNicolantonio, James J.
Publication Title: 
Journal of Cellular and Molecular Medicine

Inorganic phosphate (Pi) is required for cellular function and skeletal mineralization. Serum Pi level is maintained within a narrow range through a complex interplay between intestinal absorption, exchange with intracellular and bone storage pools, and renal tubular reabsorption. The crucial regulated step in Pi homeostasis is the transport of Pi across the renal proximal tubule. Type II sodium-dependent phosphate (Na/Pi) cotransporter (NPT2) is the major molecule in the renal proximal tubule and is regulated by Pi, parathyroid hormone and by 1,25-dihydroxyvitamin D.

Author(s): 
Takeda, Eiji
Yamamoto, Hironori
Nashiki, Kunitaka
Sato, Tadatoshi
Arai, Hidekazu
Taketani, Yutaka
Publication Title: 
Archives of Biochemistry and Biophysics
Author(s): 
Blackburn, E. H.
Hird, F. J.
Jones, I. K.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: The purpose of this pilot study was to determine whether there are markers that can be used to study the effects of grounding on delayed-onset muscle soreness (DOMS). DESIGN AND SUBJECTS: Eight (8) healthy subjects were exposed to an eccentric exercise that caused DOMS in gastrocnemius muscles of both legs. Four (4) subjects were grounded with electrode patches and patented conductive sheets connected to the earth. Four (4) control subjects were treated identically, except that the grounding systems were not connected to the earth.

Author(s): 
Brown, Dick
Chevalier, Gaétan
Hill, Michael
Publication Title: 
Bioorganic & Medicinal Chemistry

We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line.

Author(s): 
Mott, Bryan T.
He, Ran
Chen, Xiaochun
Fox, Jennifer M.
Civin, Curt I.
Arav-Boger, Ravit
Posner, Gary H.
Publication Title: 
The Indian Journal of Medical Research

Rat urine could inhibit not only the in vitro initial precipitation of calcium and phosphate/oxalate ions as mineral phase but also the subsequent growth of the preformed mineral phase. Oral administration of the aqueous extract of a commercially available Ayurvedic compound preparation to rats, was found to significantly increase the ability of the urine samples to inhibit both the initial mineral phase formation and its subsequent growth.

Author(s): 
Mago, N.
Sofat, I. B.
Jethi, R. K.
Publication Title: 
Molecular Biology of the Cell

Increased expression of vascular endothelial growth factor (VEGF) contributes to the growth of many tumors by increasing angiogenesis. Although hypoxia is a potent inducer of VEGF, we previously showed that epidermal growth factor receptor amplification and loss of PTEN, both of which can increase phosphatidylinositol-3-kinase (PI3K) activity, increase VEGF expression.

Author(s): 
Pore, Nabendu
Liu, Shuang
Shu, Hui-Kuo
Li, Bin
Haas-Kogan, Daphne
Stokoe, David
Milanini-Mongiat, Julie
Pages, Gilles
O'Rourke, Donald M.
Bernhard, Eric
Maity, Amit
Publication Title: 
Pediatric Endocrinology, Diabetes, and Metabolism

INTRODUCTION: Vegetarian diets can be healthy when they are well balanced and if a variety of foods is consumed. However, elimination of animal products from the diet (vegan diets) decreases the intake of some essential nutrients and may influence the bone metabolism. This is especially important in childhood and adolescence, when growth and bone turnover are most intensive. The aim of the study was to assess the effect of vegan diet on bone density (BMD) density and serum concentrations of bone metabolism markers.

Author(s): 
Ambroszkiewicz, Jadwiga
Klemarczyk, Witold
Gajewska, Joanna
Chełchowska, Magdalena
Franek, Edward
Laskowska-Klita, Teresa
Publication Title: 
Nutrition Journal

BACKGROUND: The acid-ash hypothesis posits that increased excretion of "acidic" ions derived from the diet, such as phosphate, contributes to net acidic ion excretion, urine calcium excretion, demineralization of bone, and osteoporosis. The public is advised by various media to follow an alkaline diet to lower their acidic ion intakes.

Author(s): 
Fenton, Tanis R.
Lyon, Andrew W.
Eliasziw, Michael
Tough, Suzanne C.
Hanley, David A.
Publication Title: 
The American Journal of Physiology

We evaluated the hypothesis that long-term caloric restriction and exercise would have beneficial effects on muscle bioenergetics and performance in the rat. By themselves, each of these interventions is known to increase longevity, and bioenergetic improvements are thought to be important in this phenomenon. Accordingly, we investigated rats that underwent long-term caloric restriction and were sedentary, ad libitum-fed rats permitted to exercise by daily spontaneous wheel running (AE), and the combination of the dietary and exercise interventions (RE).

Author(s): 
Horská, A.
Brant, L. J.
Ingram, D. K.
Hansford, R. G.
Roth, G. S.
Spencer, R. G.

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