Publication Title: 
Human & Experimental Toxicology

HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. Results show that HP-1 reversed the leakage of lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (GPT) and prevented the depletion of glutathione (GSH) levels in a primary monolayer culture of rat hepatocytes (in vitro).

Tasaduq, S. A.
Singh, K.
Sethi, S.
Sharma, S. C.
Bedi, K. L.
Singh, J.
Jaggi, B. S.
Johri, R. K.
Publication Title: 
International Journal of Food Sciences and Nutrition

Fifteen fruits commonly used by the ethnic population in Nepal were studied for the antioxidant activity and total polyphenol content (TPC). Among them, Terminalia bellirica, Terminalia chebula, Phyllanthus emblica and Spondias pinnata were the most potent antioxidants as compared with vitamin C based on the 1,1-diphenyl-2-picryl hydrazyl radical assay. These fruits also contained high TPCs. Spondias pinnata, Pyrularia edulis, Melastoma malabathricum, Cipadema bacifera and Choerospondias axillaries fruits were evaluated for the first time.

Chalise, Jaya Prakash
Acharya, Kalpana
Gurung, Nirmala
Bhusal, Ram Prasad
Gurung, Reenu
Skalko-Basnet, Natasa
Basnet, Purusotam
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM

BACKGROUND: The present study compares the protective properties of aqueous extracts of six medicinal plants, Phyllanthus emblica, Terminalia chebula (black and yellow), Terminalia arjuna, Balsamodendron Mukul and Alium sativum against lipid per-oxidation in mice brain. METHODS: The antioxidant activities were analyzed by lipid per-oxidation assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical assay, total antioxidant activity and metal chelation.

Khan, Asmatullah
Nazar, Halima
Sabir, Syed Mubashar
Irshad, Muhammad
Awan, Shahid Iqbal
Abbas, Rizwan
Akram, Muhammad
Khaliq, Abdul
Rocha, João Batista Texeira
Ahmad, Syed Dilnawaz
Malik, Farnaz
Publication Title: 
Bioscience Trends

Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide. Although several antiviral drugs have been approved for hepatitis B, they cause significant dose-dependent side-effects (interferon-alpha) and drug resistance (lamivudine, etc.). Safe and potent new anti-HBV drugs are urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China and widely used for hepatitis B in China and many parts of the world.

Cui, Xiaoyan
Wang, Yueling
Kokudo, Norihiro
Fang, Dingzhi
Tang, Wei
Publication Title: 
Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry

A wax-impregnated carbon paste electrode with mercury oxalate as the bulk modifier is found to be suitable for the determination of heavy metal ions by differential pulse anodic stripping voltammetry. The contents of binder and modifier have been optimized, until they showed low background current and easy renewability. The bulk-modified electrode is applied for the simultaneous determination of Zn, Cd, Pb and Cu in medicinal plants and Ayurvedic tablets (Liv 52). The results obtained have been validated with HMDE and AAS and are found to be comparable.

Mascarenhas, Ronald J.
Satpati, Ashis K.
Yellappa, Shivaraj
Sherigara, Bailure S.
Bopiah, Ajjikuttira K.
Publication Title: 
Biological & Pharmaceutical Bulletin

Correct genotype identification of medicinal plant material remains important for botanical drug industry. Limitations of chemical and morphological approaches for authentication have generated need for newer methods in quality control of botanicals. The present study was carried out to develop DNA based marker for identification of Phyllanthus emblica LINN. A putative marker (1.1 kb) specific for P. emblica was identified by Random Amplified Polymorphic DNA (RAPD) technique. Sequence Characterized Amplified Region (SCAR) marker was developed from the RAPD amplicon.

Dnyaneshwar, Warude
Preeti, Chavan
Kalpana, Joshi
Bhushan, Patwardhan
Publication Title: 
Asian Pacific journal of cancer prevention: APJCP

Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemopreventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as chemopreventive agents. Phyllanthus niruri is a well known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral, antibacterial, analgesic, antispasmodic and antidiabetic.

Sharma, Priyanka
Parmar, Jyoti
Verma, Preeti
Sharma, Priyanka
Goyal, P. K.
Publication Title: 
Journal of Periodontology

BACKGROUND: This study evaluated the inhibitory activity of triphala on PMN-type matrix metalloproteinase (MMP-9) expressed in adult periodontitis patients and compared its activity with another ayurvedic drug, kamillosan, and doxycycline, which has known inhibitory activity. METHODS: Matrix metalloproteinases (MMPs) were extracted from gingival tissue samples from 10 patients (six males, four females) with chronic periodontitis.

Abraham, Sajith
Kumar, M. Senthil
Sehgal, P. K.
Nitish, S.
Jayakumar, N. D.
Publication Title: 
Digestive Diseases and Sciences

Herbal medicines have been used in the treatment of liver diseases for a long time. A number of herbal preparations are available in the market. This article reviews four commonly used herbal preparations: (1) Phyllanthus, (2) Silybum marianum (milk thistle), (3) glycyrrhizin (licorice root extract), and (4) Liv 52 (mixture of herbs).

Dhiman, Radha K.
Chawla, Yogesh K.
Publication Title: 
Journal of Ethnopharmacology

Different species of Phyllanthus are considered to be very effective hepatoprotective agents in the Indian indigenous systems of medicine and are considered bitter, astringent, stomachic, diuretic, febrifuge, deobstruant and antiseptic. Still ayurvedic practitioners prescribed fresh juice of 'Bhuiamlki' for jaundice. Various species of Phyllanthus are being sold in India under the trade name 'Bhuiamlki'. During market surveillance of herbal drug, it was observed that almost all the commercial samples, either comprise of Phyllanthus amarus Schum & Thonn.

Khatoon, Sayyada
Rai, Vartika
Rawat, Ajay Kumar Singh
Mehrotra, Shanta


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