Pituitary-Adrenal System

Publication Title: 
Neuropharmacology

Posttraumatic Stress Disorder (PTSD) is an anxiety disorder which can develop as a result of exposure to a traumatic event and is associated with significant functional impairment. Family and twin studies have found that risk for PTSD is associated with an underlying genetic vulnerability and that more than 30% of the variance associated with PTSD is related to a heritable component.

Author(s): 
Skelton, Kelly
Ressler, Kerry J.
Norrholm, Seth D.
Jovanovic, Tanja
Bradley-Davino, Bekh
Publication Title: 
Neuropharmacology

Post-traumatic stress disorder (PTSD) is a severely debilitating psychiatric condition. Although a lifetime trauma incidence of 40-90% has been reported in the general population, the overall lifetime prevalence for PTSD ranges between 7-12%, suggesting individual-specific differences towards the susceptibility to PTSD. While studies investigating main genetic effects associated with PTSD have yielded inconsistent findings, there is growing evidence supporting the role of gene-environment (G ◊ E) interactions in PTSD.

Author(s): 
Mehta, Divya
Binder, Elisabeth B.
Publication Title: 
Dialogues in Clinical Neuroscience

Major depressive disorder (MDD) is associated with a high rate of developing serious medical comorbidities such as cardiovascular disease, stroke, dementia, osteoporosis, diabetes, and the metabolic syndrome. These are conditions that typically occur late in life, and it has been suggested that MDD may be associated with "accelerated aging." We review several moderators and mediators that may accompany MDD and that may give rise to these comorbid medical conditions.

Author(s): 
Wolkowitz, Owen M.
Reus, Victor I.
Mellon, Synthia H.
Publication Title: 
Dialogues in Clinical Neuroscience

Maternal perinatal mental health has enormous consequences for the well-being of the mother, her baby, and the family. Although it is well documented that perinatal depression is both common and morbid, with a prevalence of 10% to 15% in the general population, there remain many critically important unanswered questions about the pathogenesis of perinatal depression and most effective treatment regimens.

Author(s): 
Meltzer-Brody, Samantha
Publication Title: 
CNS drugs

Depression is a prevalent, highly debilitating mental disorder affecting up to 15% of the population at least once in their lifetime, with huge costs for society. Neurobiological mechanisms of depression are still not well known, although there is consensus about interplay between genetic and environmental factors. Antidepressant medications are frequently used in depression, but at least 50% of patients are poor responders, even to more recently discovered medications.

Author(s): 
Masi, Gabriele
Brovedani, Paola
Publication Title: 
Trends in Neurosciences

Suicide and related behaviors are complex phenomena associated with different risk factors. Although most individuals who display suicidal behavior do not have a history of early-life adversity, a significant minority does. Recent animal and human data have suggested that early-life adversity leads to epigenetic regulation of genes involved in stress-response systems.

Author(s): 
Turecki, Gustavo
Ernst, Carl
Jollant, Fabrice
LabontÈ, Benoit
Mechawar, Naguib
Publication Title: 
Early Intervention in Psychiatry

AIM: The study aims to provide a selective review of the literature pertaining to the hypothalamic-pituitary-adrenal (HPA) axis and immune abnormalities as informative biological indicators of vulnerability in bipolar disorder (BD). METHOD: We summarize key findings relating to HPA axis and immunological abnormalities in bipolar patients and their high-risk offspring. Findings derive from a review of selected original papers published in the literature, and supplemented by papers identified through bibliography review.

Author(s): 
Duffy, Anne
Lewitzka, Ute
Doucette, Sarah
Andreazza, Ana
Grof, Paul
Publication Title: 
Psychiatria Polska

The authors of this paper present a review of actual data on the neurobiological background of suicidal behaviour. The results of epidemiological studies suggest that suicidal behaviours have certain genetic background which do not depend on the presence of concomitant mental disorders. The estimated heritability rate of suicide is about 21-50%, while the heritability rate of suicidal ideation and behaviour is about 30-55%. The genes of serotonergic and noradrenergic systems, as well as the HPA axis genes, have been scrutinised in context of suicidal behaviour.

Author(s): 
Jaeschke, Rafa?
Siwek, Marcin
Dudek, Dominika
Publication Title: 
Epigenomics

Social stress is a major factor contributing to early-life adversity that has taken on an epidemic scale. Early social stress leads to long-lasting changes in behavior, cognition, mood and neuroendocrine responses predisposing to or sheltering from stress-related diseases later in life. Epigenetic mechanisms are thought to mediate the effects of early social stress on the epigenome, and can give rise to persistent memories hard coded by DNA methylation.

Author(s): 
Hoffmann, Anke
Spengler, Dietmar
Publication Title: 
Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica

In addition to genetic factors, the role of epigenetic and other environmental factors in the promotion of anxiety disorder has attracted much attention in psychiatric research. When stress is encountered in the environment, the hypothalamus-pituitary adrenal system (HPA system) is activated and cortisol is secreted. CRHR gene function is closely related to this response. As a result of haplotype analysis of CRHR genes in depression and panic disorder patients, it was found that genetic polymorphism of CRHR1 and CRHR2 was related to both disorders.

Author(s): 
Akiyoshi, Jotaro

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