Plant Components, Aerial

Publication Title: 
Planta Medica

Medicinal plants are a rich source of ligands for nuclear receptors. The present study was aimed to screen a collection of plant extracts for PPAR?/?-activating properties and identify the active extract that can stimulate cellular glucose uptake without enhancing the adipogenesis. A reporter gene assay was performed to screen ethanolic extracts of 263 plant species, belonging to 94 families, for activation of PPAR? and PPAR?. Eight extracts showed activation of PPAR?, while 22 extracts showed activation of PPAR?.

Author(s): 
Yang, Min Hye
Avula, Bharathi
Smillie, Troy
Khan, Ikhlas A.
Khan, Shabana I.
Publication Title: 
Planta Medica

The Mexican species GALPHIMIA GLAUCA (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cell suspension cultures of this species were established in order to induce a greater production of nor-friedelanes. The cell suspension line GgBa was selected and grown over a period of two years of continuous subculturing in MS nutrient medium in the absence of growth regulators.

Author(s): 
Ortíz, Anabel
Cardoso-Taketa, Alexandre
Monroy, Mario Rodríguez
Arellano, Jesús
Hernández, Georgina
Villarreal, María Luisa
Publication Title: 
Antimicrobial Agents and Chemotherapy

The antimalarial drug artemisinin from Artemisia annua demonstrated remarkably strong activity against Helicobacter pylori, the pathogen responsible for peptic ulcer diseases. In an effort to develop a novel antimicrobial chemotherapeutic agent containing such a sesquiterpene lactone endoperoxide, a series of analogues (2 natural and 15 semisynthetic molecules), including eight newly synthesized compounds, were investigated against clinical and standard strains of H. pylori. The antimicrobial spectrum against 10 H.

Author(s): 
Goswami, Suchandra
Bhakuni, Rajendra S.
Chinniah, Annalakshmi
Pal, Anirban
Kar, Sudip K.
Das, Pratap K.
Publication Title: 
Yao Xue Xue Bao = Acta Pharmaceutica Sinica

To establish an HPLC-UV-ELSD method for the determination of the content of artemisinin, arteannuin B and artemisinic acid in Herba Artemisiae Annuae. The analytical column was Nucleodur RP-C18 (250 mm x 4.6 mm, 5 microm ID). The mobile phase was acetonirile-0.1% acetic acid (50: 50) and the flow rate was 1.0 mL x min(-1) with a UV detector for artemisinin, the detection wavelength at 209 nm, and the evaporative light-scattering detector (ELSD) for arteannuin B and artemisinic acid, the drift tube temperature: 50 degrees C, the nitrogen flow rate 30 psi and the gain was 50.

Author(s): 
Zhang, Dong
Yang, Lan
Yang, Li-Xin
Wang, Man-Yuan
Tu, You-you
Publication Title: 
Biological & Pharmaceutical Bulletin

In Ayurveda and Thai traditional medicines, material from Coscinium fenestratum is commonly prescribed as active ingredients with diverse therapeutic purposes. However, C. fenestratum is also a seriously endangered medicinal liana. Thus, its crude material is very rare and is being substituted with substances from Arcangelisia flava or Fibraurea tinctoria (Menispermaceae), which have high morphological similarity.

Author(s): 
Watthanachaiyingcharoen, Rith
Komatsu, Katsuko
Zhu, Shu
Vajragupta, Opa
Leelamanit, Wichet
Publication Title: 
Journal of Oleo Science

The chemical composition of volatile oil obtained from aerial parts of Pavonia odorata were investigated using gas chromatography-mass spectrometry (GC-MS). Its aroma-active compounds were identified using gas chromatography-olfactometry (GC-O) and aroma extraction dilution analysis (AEDA). In order to determine the relative contribution of each compound to the aroma of P. odorata, relative flavour activity (RFA) was calculated. The hydrodistillation of P. odorata afforded yellowish oil and the yield was 0.009% (w/w) with a spicy, sweet, and green odour.

Author(s): 
Kashima, Yusei
Nakaya, Satoshi
Miyazawa, Mitsuo
Publication Title: 
The Journal of Pharmacy and Pharmacology

Croton klozchianus is a relatively uninvestigated species with no pharmacological or phytochemical reports available, although it has been used clinically by Ayurvedic physicians to treat diabetes. We have investigated this use by studying the insulin secretion and antidiabetic activity of C. klozchianus. Treatment of diabetic rats with aerial parts of C. klozchianus extract (CK, 100 and 300 mg kg(-1) body weight) for three weeks showed significant reduction in blood glucose (45.8% after 14 days for 300 mg kg(-1)). C.

Author(s): 
Govindarajan, R.
Vijayakumar, M.
Rao, Ch V.
Pushpangadan, P.
Asare-Anane, Henry
Persaud, Shanta
Jones, Peter
Houghton, Peter J.
Publication Title: 
Fitoterapia

Identification of medicinal plants by their molecular signature is a fast growing tool. The identification of Desmodium gangeticum (L.) DC. (Shalparni, a constituent of Ayurvedic formulation "Dashmoolarishtha") was carried out using genomic approach. Authentic samples of D. gangeticum(L.) DC., D. velutinum (Willd.) DC. and D. triflorum (L.) DC. were analyzed and compared to commercial samples of various origin. Within twenty primers used, eleven gave 223 RAPD fragments.

Author(s): 
Irshad, Saba
Singh, Jyotsna
Kakkar, Poonam
Mehrotra, Shanta
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Bacopa monnieri (L.) Wettst., a plant belonging to the family Scrophulariaceae, has been used in the traditional system of Ayurvedic medicine to improve intelligence and memory for a long time. Therefore, the potential of this plant to protect against Alzheimer's disease has been raised but less supported document is available. AIM OF THE STUDY: To determine the effect of alcoholic extract of Bacopa monnieri on cognitive function and neurodegeneration in animal model of Alzheimer's disease induced by ethylcholine aziridinium ion (AF64A).

Author(s): 
Uabundit, Nongnut
Wattanathorn, Jintanaporn
Mucimapura, Supaporn
Ingkaninan, Kornkanok
Publication Title: 
Biological & Pharmaceutical Bulletin

In Ayurveda and Thai traditional medicines, material from Coscinium fenestratum is commonly prescribed as active ingredients with diverse therapeutic purposes. However, C. fenestratum is also a seriously endangered medicinal liana. Thus, its crude material is very rare and is being substituted with substances from Arcangelisia flava or Fibraurea tinctoria (Menispermaceae), which have high morphological similarity.

Author(s): 
Watthanachaiyingcharoen, Rith
Komatsu, Katsuko
Zhu, Shu
Vajragupta, Opa
Leelamanit, Wichet

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