Plant Extracts

Publication Title: 
Rejuvenation Research

A botanical extract (Regrapex-R) prepared from whole grape (Vitis vinifera) and Polygonum cuspidatum, which contains polyphenols, including flavans, anthocyanins, emodin, and resveratrol, exhibited dose-dependent scavenging effects on reactive oxygen species (ROS). The extract inhibited increases of ROS and protein carbonyl in isolated rat liver mitochondria following exposure to 2,2'-azobis (2-amidino propane) dihydrocholoride (AAPH), a potent lipid oxidant generator.

Long, Jiangang
Gao, Hongxiang
Sun, Lijuan
Liu, Jiankang
Zhao-Wilson, Xi
Publication Title: 
Journal of Agricultural and Food Chemistry

Dry bean consumption has been reported to be associated with reduced risk for a number of chronic diseases including cancer. The extent to which these benefits are associated with primary versus secondary plant metabolites is not known. The work reported herein focuses on low molecular weight secondary metabolites and uses longevity extension of wild-type Caenorhabditis elegans nematodes as a surrogate marker for human health benefits.

Mensack, Meghan M.
Fitzgerald, Vanessa K.
Lewis, Matthew R.
Thompson, Henry J.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Extracts of Sasa senanensis Rehder are used in traditional Japanese medicine; however, little is known about the underlying mechanisms of their potential health benefits. METHODS: S. senanensis leaves were extracted with subcritical water. An active small-molecule was isolated using reversed-phase high-performance liquid chromatography (HPLC), and identified as 3,4-dihydroxybenzaldehyde (protocatechuic aldehyde or PA). The effects of PA on the activity of histone demethylase, the Drosophila melanogaster lifespan and gene expression in Drosophila S2 cells were investigated.

Nakagawa-Yagi, Yuzo
Sato, Yukiko
Matsumoto, Emi
Nakatsuka, Shin-Ichi
Sakaki, Tsuyoshi
Muramatsu, Yukiko
Hara, Takaaki
Aigaki, Toshiro
Publication Title: 
PloS One

BACKGROUND: Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies.

Dwivedi, Vibha
Anandan, E. M.
Mony, Rajesh S.
Muraleedharan, T. S.
Valiathan, M. S.
Mutsuddi, Mousumi
Lakhotia, Subhash C.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Eucommia ulmoides Oliv. Bark. (EUE), has commonly been used to fortify the muscles and lungs, lower blood pressure, prevent miscarriage, improve the tone of liver and kidneys, and promote longevity the traditional tonic medicines of Korea, China, and Japan. AIM OF THE STUDY: In this study, we investigated that the neuroprotective activities and possible mechanisms of EUE aqueous extract in hydrogen peroxide (H(2)O(2))-induced neuronal cell death in human SH-SY5Y neuroblastoma cells.

Kwon, Seung-Hwan
Kim, Min-Jung
Ma, Shi-Xun
You, In-Jee
Hwang, Ji-Young
Oh, Ji-Hwan
Kim, Sun-Yeou
Kim, Hyoung-Chun
Lee, Seok-Yong
Jang, Choon-Gon
Publication Title: 
Neurochemistry International

Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in normal ageing as well as in neurodegenerative processes.

Steele, Megan L.
Truong, John
Govindaraghavan, Suresh
Ooi, Lezanne
Sucher, Nikolaus J.
M¸nch, Gerald
Publication Title: 
Chembiochem: A European Journal of Chemical Biology
Quideau, StÈphane
Publication Title: 
Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society

It is well documented that reactive oxygen species (ROS) are involved in the aetiology of age related diseases. Over the last decades, strong efforts have been made to identify antioxidants in human foods and numerous promising compounds have been detected which are used for the production of supplements and functional foods. The present paper describes the advantages and limitations of methods which are currently used for the identification of antioxidants. Numerous in vitro methods are available which are easy to perform and largely used in screening trials.

Hoelzl, C.
Bichler, J.
Ferk, F.
Simic, T.
Nersesyan, A.
Elbling, L.
Ehrlich, V.
Chakraborty, A.
Knasm¸ller, S.
Publication Title: 
Pakistan journal of biological sciences: PJBS

Neem leaf dust and a commercial formulation of neem were tested on adult Bactrocera cucurbitae (Coquillett) and Bactrocera dorsalis (Hendel) to determine their effects on the longevity, fecundity and ovarian development. Different combinations of neem leaf dust and a commercial formulation of a neem compound incorporated with sugar solution and adult rearing diets were tested. The Laboratory tests showed that ingestion of neem can significantly reduced the longevity and fertility of both the fly species.

Khan, Mahfuza
Aftab Hossain, M.
Saidul Islam, M.
Publication Title: 
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift F¸r Vitamin- Und Ern‰hrungsforschung. Journal International De Vitaminologie Et De Nutrition

Nutrition is a central factor in today's observed aging of the population. However, the good prospect of longevity is overshadowed by the high prevalence of mental decline in old age. The most prevalent form of neurodegeneration is Alzheimer's disease(AD) reaching a prevalence of over 30 % above age 80.The question is reviewed whether nutrients may protect or slow down the age associated mental decline due to neuronal degeneration.

Staehelin, Hannes B.


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