Plaque, Atherosclerotic

Publication Title: 
Postgraduate Medicine

Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for cardiovascular events and mortality. Calcification of the arterial media and of heart valves clearly plays a mediating role in this regard, whereas it is less clear how calcification of plaque influences atherogenesis and risk for plaque rupture. Vascular calcification is an active process in which vascular smooth muscle cells (VSMCs) adopt an osteoblastic phenotype and deposit hydroxyapatite crystals; apoptosis of VSMCs also promotes this deposition.

McCarty, Mark F.
DiNicolantonio, James J.
Publication Title: 
Journal of Lipid Research

12/15 lipoxygenase (12/15LO) oxidizes polyunsaturated fatty acids (PUFAs) to form bioactive lipid mediators. The role of 12/15LO in atherosclerosis development remains controversial. We evaluated atherosclerosis development and lipid metabolism in 12/15LO-LDL receptor (LDLr) double knockout (DK) vs. LDLr knockout (SK) mice fed a PUFA-enriched diet to enhance production of 12/15LO products.

Rong, Shunxing
Cao, Qiang
Liu, Mingxia
Seo, Jeongmin
Jia, Lin
Boudyguina, Elena
Gebre, Abraham K.
Colvin, Perry L.
Smith, Thomas L.
Murphy, Robert C.
Mishra, Nilamadhab
Parks, John S.
Publication Title: 
PloS One

Inflammation and oxidative stress play fundamental roles in the pathogenesis of atherosclerosis. Myeloperoxidase has been extensively implicated as a key mediator of inflammatory and redox-dependent processes in atherosclerosis. However, the effect of synthetic myeloperoxidase inhibitors on atherosclerosis has been insufficiently studied. In this study, ApoE(-/-) mice were randomized to low- and high-dose INV-315 groups for 16 weeks on high-fat diet. INV-315 resulted in reduced plaque burden and improved endothelial function in response to acetylcholine.

Liu, Cuiqing
Desikan, Rajagopal
Ying, Zhekang
Gushchina, Liubov
Kampfrath, Thomas
Deiuliis, Jeffrey
Wang, Aixia
Xu, Xiaohua
Zhong, Jixin
Rao, Xiaoquan
Sun, Qinghua
Maiseyeu, Andrei
Parthasarathy, Sampath
Rajagopalan, Sanjay
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