Plasma

Publication Title: 
Transfusion Clinique Et Biologique: Journal De La Societe Francaise De Transfusion Sanguine

Blood donation is an act of solidarity. Most often, this act is done on a volunteer basis and, depending on countries and circumstances, is not remunerated. The increase in need, the always-greater number of deferral criteria, the safety issues and the changes in the structures of our societies are among the many subjects for ethical debates.

Author(s): 
Tissot, J.-D.
Garraud, O.
Danic, B.
Cabaud, J.-J.
LefrËre, J.-J.
Publication Title: 
The Journal of Antimicrobial Chemotherapy

OBJECTIVES: The aim was to study the pharmacokinetic profile of artesunate and its metabolite dihydroartemisinin (DHA) in a pig model. METHODS: Thirteen pigs received either intravenous (iv) or intramuscular (im) artesunate (60 mg), with the alternative preparation given 24 h later in an open crossover design. Five of them also received an additional intra-arterial (ia) artesunate dose (60 mg). The plasma concentrations of artesunate and DHA were determined by high-performance liquid chromatography with electrochemical detection.

Author(s): 
Sinou, Veronique
Taudon, Nicolas
Mosnier, Joël
Aglioni, Christian
Bressolle, Françoise M. M.
Parzy, Daniel
Publication Title: 
The Journal of Antimicrobial Chemotherapy

OBJECTIVES: The pharmacokinetic (PK) parameters of artesunate, recently discovered to possess promising trematocidal activity, and its main metabolite dihydroartemisinin (DHA) were determined in rats infected with hepatic and biliary stages of Fasciola hepatica and compared with uninfected rats after single intragastric and intravenous (iv) doses. METHODS: Rats infected with F.

Author(s): 
Keiser, Jennifer
Gruyer, Marie-Stella
Perrottet, Nancy
Zanolari, Boris
Mercier, Thomas
Decosterd, Laurent
Publication Title: 
Malaria Journal

BACKGROUND: Pharmacokinetic (PK) data on amodiaquine (AQ) and artesunate (AS) are limited in children, an important risk group for malaria. The aim of this study was to evaluate the PK properties of a newly developed and registered fixed dose combination (FDC) of artesunate and amodiaquine. METHODS: A prospective population pharmacokinetic study of AS and AQ was conducted in children aged six months to five years. Participants were randomized to receive the new artesunate and amodiaquine FDC or the same drugs given in separate tablets.

Author(s): 
Stepniewska, Kasia
Taylor, Walter
Sirima, Sodiomon B.
Ouedraogo, Esperance B.
Ouédraogo, Alphonse
Gansané, Adama
Simpson, Julie A.
Morgan, Caroline C.
White, Nicholas J.
Kiechel, Jean-René
Publication Title: 
Malaria Journal

BACKGROUND: Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were considered possible alternatives to SP in Malawi. The aim of this study was to investigate the impact of poor adherence on the effectiveness of AL and CPD. METHODS: Children > or =12 months and adults with uncomplicated malaria were randomized to receive AL, CPD or SP.

Author(s): 
Bell, David J.
Wootton, Dan
Mukaka, Mavuto
Montgomery, Jacqui
Kayange, Noel
Chimpeni, Phillips
Hughes, Dyfrig A.
Molyneux, Malcolm E.
Ward, Steve A.
Winstanley, Peter A.
Lalloo, David G.
Publication Title: 
Malaria Journal

BACKGROUND: The population pharmacokinetics of artesunate (AS) and its active metabolite dihydroartemisinin (DHA) were studied in healthy subjects receiving single- or multiple-dosing of AS orally either in combination with pyronaridine (PYR) or as a monotherapy with or without food. METHODS: Data from 118 concentration-time profiles arising from 91 healthy Korean subjects were pooled from four Phase I clinical studies. Subjects received 2-5 mg/kg of single- and multiple-dosing of oral AS either in combination with PYR or as a monotherapy with or without food.

Author(s): 
Tan, Beesan
Naik, Himanshu
Jang, In-Jin
Yu, Kyung-Sang
Kirsch, Lee E.
Shin, Chang-Sik
Craft, J. Carl
Fleckenstein, Lawrence
Publication Title: 
European Journal of Clinical Pharmacology

PURPOSE: Dihydroartemisinin-piperaquine (DP) is a fixed-dose artemisinin-based combination treatment. Field pharmacokinetic studies would be simplified and facilitated by being able to use small volume capillary assays rather than venous blood. The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma.

Author(s): 
Ashley, Elizabeth A.
Stepniewska, Kasia
Lindegardh, Niklas
Annerberg, Anna
Tarning, Joel
McGready, Rose
Phaiphun, Lucy
Singhasivanon, Pratap
White, Nicholas J.
Nosten, François
Publication Title: 
Malaria Journal

BACKGROUND: Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated falciparum malaria in Thailand was monitored in an area along the western border (Thai-Myanmar) of the country.

Author(s): 
Na-Bangchang, Kesara
Ruengweerayut, Ronnatrai
Mahamad, Poonuch
Ruengweerayut, Kulaya
Chaijaroenkul, Wanna
Publication Title: 
Malaria Journal

BACKGROUND: Artemether-lumefantrine is one of the most widely used anti-malarial drug combinations in the world with excellent tolerability and cure rates in adult and paediatric patients with uncomplicated falciparum malaria. The aim of this study was to evaluate the pharmacokinetics of artemether and its active metabolite, dihydroartemisinin, in healthy Pakistani volunteers. METHODS: Twelve healthy male Pakistani subjects, aged 20 to 50, were recruited into the study. A fixed oral combination of artemether-lumefantrine (80-480 mg) was given as a single oral dose.

Author(s): 
Ali, Shabana
Najmi, Muzammil H.
Tarning, Joel
Lindegardh, Niklas
Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

BACKGROUND: Increasing rates of failure of artemisinin-based combination therapy have highlighted the possibility of emerging artemisinin resistance along the Thai-Cambodian border. We used an integrated in vivo-in vitro approach to assess the presence of artemisinin resistance in western Cambodia. This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine.

Author(s): 
Noedl, Harald
Se, Youry
Sriwichai, Sabaithip
Schaecher, Kurt
Teja-Isavadharm, Paktiya
Smith, Bryan
Rutvisuttinunt, Wiriya
Bethell, Delia
Surasri, Sittidech
Fukuda, Mark M.
Socheat, Duong
Chan Thap, Lon

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