Plasmodium berghei

Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

OBJECTIVE: To evaluate the in vitro and in vivo antiplasmodial activity and the cytotoxicity of Phyllanthus emblica Linn, Terminalia chebula Retz, and Terminalia bellerica (Gaertn) Roxb extracts. MATERIAL AND METHOD: Standard phytochemical screening tests were used to detect metabolites in the plant extract. The water extracts of medicinal plants were tested for their antiplasmodial activity in vitro by assessing their ability to inhibit the uptake of [3H] hypoxanthine into the Plasmodium falciparum K1 multidrug-resistant strain.

Pinmai, Khosit
Hiriote, Wanwarang
Soonthornchareonnon, Noppamas
Jongsakul, Krisada
Sireeratawong, Seewaboon
Tor-Udom, Siripen
Publication Title: 
PLoS pathogens

A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens or symbionts that express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly, there is still a paucity of effector molecules with potent anti-malaria activity whose expression does not cause detrimental effects on mosquito fitness. Our objective was to examine a wide range of antimicrobial peptides (AMPs) for their toxic effects on Plasmodium and anopheline mosquitoes.

Carter, Victoria
Underhill, Ann
Baber, Ibrahima
Sylla, Lakamy
Baby, Mounirou
Larget-Thiery, Isabelle
Zettor, AgnËs
Bourgouin, Catherine
Langel, Ulo
Faye, Ingrid
Otvos, Laszlo
Wade, John D.
Coulibaly, Mamadou B.
Traoré, Sekou F.
Tripet, Frederic
Eggleston, Paul
Hurd, Hilary
Publication Title: 
Journal of the Royal Society of Medicine

With the current increase of international travel and increasing drug resistance, United Kingdom residents stand a high risk of contracting malaria when they visit endemic countries. The development of anti-malarial agents from old traditional plant remedies to modern synthetic drugs is briefly reviewed. Resistance to the latter has spread rapidly since the 1950s, culminating in the widespread distribution of multiple drug-resistant strains of Plasmodium falciparum in most endemic areas.

Peters, W.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

The effects of alpha-dimethylamino-cyclohexoxyl-dimethyl gallium (DCDG), a new antimalarial drug developed in China, on the ultrastructure of murine malaria parasites in vivo was studied in comparison with those of chloroquine (CQ) and artemisinin (Art). All these 3 antimalarials were administered ig to mice at dosages of 1-3, 40-80, and 200-400 for DCDG, CQ, and Art respectively, based on a similar intensity of morphological changes in the parasites. Blood samples were collected for electron microscopy from 15 min to 48 h after medication.

Yan, G. H.
Wang, G. J.
Li, Y. C.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effects of artesunate (dihydroartemisinine-12-alpha-succinate, Art) on immune function in mice. METHODS: Hemolysin concentration was determined by colorimetric method. Serum IgG and C3 contents were measured by single immunodiffusion method. Percentage of lymphocyte transformation, phagocytosis percentage and phagocytic index were counted under microscope. RESULTS: Art im 75 mg kg-1 bid x 7 d decreased the humolysin-forming capacity and levels of serum IgG of mice sensitized with sheep red blood cell.

Lin, P. Y.
Feng, Z. M.
Pan, J. Q.
Zhang, D.
Xiao, L. Y.
Publication Title: 
The Journal of Antimicrobial Chemotherapy

Plasmodium berghei ANKA infected C57B1/6 mice develop cerebral malaria at a parasitaemia of 15-25%. When parasitaemia reached 10%, P. berghei infected mice were treated with artemether, chloroquine or clindamycin in order to prevent the occurrence of cerebral malaria. Artemether and chloroquine were highly efficient. Functional tests revealed that zymosan stimulated spleen cells from untreated mice with cerebral malaria showed a slight decrease in their capacity to produce reactive oxygen intermediates (ROI) when compared with naive mice.

Prada, J.
Müller, S.
Bienzle, U.
Kremsner, P. G.
Publication Title: 
The Journal of Antibiotics

In the course of our screening program for artemisinin-like antimalarial compounds from microorganisms, seven fungal metabolites such as radicicol and heptelidic acid were identified as active compounds. Some of them exhibited antimalarial activity in vitro against the human malaria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo against Plasmodium berghei in mice.

Tanaka, Y.
Shiomi, K.
Kamei, K.
Sugoh-Hagino, M.
Enomoto, Y.
Fang, F.
Yamaguchi, Y.
Masuma, R.
Zhang, C. G.
Zhang, X. W.
Omura, S.
Publication Title: 
Tropical medicine & international health: TM & IH

Glutathione-S-transferase (GST) activity has been detected in rodent (Plasmodium berghei, P. yoelii), simian (P. knowlesi) and human (P. falciparum) malarial parasites, and in different intraerythrocytic stages of P. knowlesi (schizont > ring > trophozoite). In chloroquine-resistant strains of rodent and human malarial parasites GST activity significantly increases compared to sensitive strains. Further, the increase in enzyme activity is directly related to drug pressure of resistant P. berghei. Complete inhibition of chloroquine-sensitive and resistant P.

Srivastava, P.
Puri, S. K.
Kamboj, K. K.
Pandey, V. C.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the blood schizontocidal effect of oral artesunate on P berghei in mice and P knowlesi in monkey. METHODS: Effects of artesunate and chloroquine were detected with "4-day test" and "28-day test" on P berghei in mice and "7-day test" on P knowlesi in Macaca mudatta. RESULTS: The suppressive efficacy of oral artesunate was inferior to chloroquine on P berghei K173 strain but the time for 50% and 90% reduction and the time of clearance of parasitemia was 10-15 h shorter than that of chloroquine.

Shi, Y. L.
Li, G. F.
Zhao, J. H.
Yang, J. D.
Ding, D. B.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum. In consideration of the contrasting antagonism between artemisinin and chloroquine, these drug combination data imply that WR 148999 and artemisinin may not share a common mechanism of action.

Vennerstrom, J. L.
Ager, A. L.
Andersen, S. L.
Grace, J. M.
Wongpanich, V.
Angerhofer, C. K.
Hu, J. K.
Wesche, D. L.


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