Platelet Adhesiveness

Publication Title: 
International Journal of Cardiology

Four groups of 25 rabbits each, were studied to determine the effect of Haritaki (Terminalia chebula), Amla (Emblica officinalis) and Bahira (Terminalia belerica) on cholesterol-induced hypercholesteolaemia and atherosclerosis. The control group was fed with cholesterol alone; the Haritaki group received Haritaki and cholesterol; the Bahira group received Bahira and cholesterol; and the Amla group received Amla and cholesterol for 16 weeks.

Author(s): 
Thakur, C. P.
Thakur, B.
Singh, S.
Sinha, P. K.
Sinha, S. K.
Publication Title: 
International Journal of Cardiology

Four groups of 25 rabbits each, were studied to determine the effect of Haritaki (Terminalia chebula), Amla (Emblica officinalis) and Bahira (Terminalia belerica) on cholesterol-induced hypercholesteolaemia and atherosclerosis. The control group was fed with cholesterol alone; the Haritaki group received Haritaki and cholesterol; the Bahira group received Bahira and cholesterol; and the Amla group received Amla and cholesterol for 16 weeks.

Author(s): 
Thakur, C. P.
Thakur, B.
Singh, S.
Sinha, P. K.
Sinha, S. K.
Publication Title: 
Intensive Care Medicine

PURPOSE: Impaired microvascular perfusion in sepsis is not treated effectively because its mechanism is unknown. Since inflammatory and coagulation pathways cross-activate, we tested if stoppage of blood flow in septic capillaries is due to oxidant-dependent adhesion of platelets in these microvessels. METHODS: Sepsis was induced in wild type, eNOS(-/-), iNOS(-/-), and gp91phox(-/-) mice (n = 14-199) by injection of feces into the peritoneum. Platelet adhesion, fibrin deposition, and blood flow stoppage in capillaries of hindlimb skeletal muscle were assessed by intravital microscopy.

Author(s): 
Secor, Dan
Li, Fuyan
Ellis, Christopher G.
Sharpe, Michael D.
Gross, Peter L.
Wilson, John X.
Tyml, Karel
Publication Title: 
The Journal of Biological Chemistry

Neuroinflammation and traumatic brain injury involve activation of inflammatory cells and production of local pro-inflammatory mediators that can amplify tissue damage. Using LC-UV-MS-MS-based lipidomics in tandem with functional screening at the single-cell level in microfluidic chambers, we identified a series of novel bioactive oxygenated docosahexaenoyl ethanolamide- (DHEA) derived products that regulated leukocyte motility.

Author(s): 
Yang, Rong
Fredman, Gabrielle
Krishnamoorthy, Sriram
Agrawal, Nitin
Irimia, Daniel
Piomelli, Daniele
Serhan, Charles N.
Publication Title: 
PloS One

BACKGROUND: Salvianolic acid B (SB) is an active component isolated from Danshen, a traditional Chinese medicine widely used for the treatment of cardiovascular disorders. Previous study suggested that SB might inhibit adhesion as well as aggregation of platelets by a mechanism involving the integrin α2β1. But, the signal cascades in platelets after SB binding are still not clear.

Author(s): 
Ma, Chao
Yao, Yan
Yue, Qing-Xi
Zhou, Xin-Wen
Yang, Peng-Yuan
Wu, Wan-Ying
Guan, Shu-Hong
Jiang, Bao-Hong
Yang, Min
Liu, Xuan
Guo, De-An
Publication Title: 
Oncology Reports

Cancer metastasis is a highly coordinated and dynamic multistep process in which cancer cells interact with a variety of host cells. Morphological studies have documented the association of circulating tumor cells with host platelets, where a surface coating of platelets protects tumor cells from mechanical trauma and the immune system. Cantharidin is an active constituent of mylabris, a traditional Chinese medicine.

Author(s): 
Shou, Liu-Mei
Zhang, Qiong-Yan
Li, Wei
Xie, Xin
Chen, Kai
Lian, Lian
Li, Zhen-Yu
Gong, Fei-Ran
Dai, Ke-Sheng
Mao, Yi-Xiang
Tao, Min
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