Platelet Aggregation

Publication Title: 
Molecular Nutrition & Food Research

Interest in the Mediterranean diet (MD) has grown worldwide due to its link with greater longevity and lower cardiovascular disease rate, cancer and age cognitive decline. Despite the high complexity of its nutrients composition, olive oil emerges as its principal food, since it provides the higher percent of energy and a lot of bioactive compounds. In this review we will discuss the benefits of diets enriched in virgin olive oil, whose effects are probably due not only to its oleic acid content but also to its other potentially health-promoting components.

Author(s): 
Lopez-Miranda, Jose
Delgado-Lista, Javier
Perez-Martinez, Pablo
Jimenez-GÛmez, Yolanda
Fuentes, Francisco
Ruano, Juan
Marin, Carmen
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Ayurveda, the Indian traditional system of medicine describes a unique concept "prakriti", genetically determined, categorising the population into several subgroups based on phenotypic characters like appearance, temperament and habits. The concept is claimed to be useful in predicting an individual's susceptibility to a particular disease, prognosis of that illness and selection of therapy. The present study was carried out to study if the platelet aggregatory response and its inhibition by aspirin varied in the different prakriti subtypes.

Author(s): 
Bhalerao, Supriya
Deshpande, Tejashree
Thatte, Urmila
Publication Title: 
Prostaglandins, Leukotrienes, and Essential Fatty Acids

In traditional medicine, Ayurveda, several spices and herbs are held to possess medicinal properties. Earlier we have reported that extracts from several spices, including turmeric, inhibit platelet aggregation and modulate eicosanoid biosynthesis. Due to their eicosanoid-modulating property, it was suggested that the spices may serve to provide clues to drugs directed to arachidonic acid (AA) pathway enzymes as pharmacological targets. Curcumin, a major component of turmeric, inhibited platelet aggregation induced by arachidonate, adrenaline and collagen.

Author(s): 
Srivastava, K. C.
Bordia, A.
Verma, S. K.
Publication Title: 
Prostaglandins, Leukotrienes, and Essential Fatty Acids

In the traditional Indian system of medicine, Ayurveda, several spices and herbs are claimed to possess medicinal properties, such as being antithrombotic, antiatherosclerotic, hypolipidemic, anti-inflammatory etc. Earlier we have reported that extracts from several spices behave as antiaggregatory agents and inhibit eicosanoid synthesis. Similar studies with extracts prepared from cumin (Cuminum cyminum) and turmeric (Curcuma longa) were undertaken. Ethereal extract of both cumin and turmeric inhibited arachidonate-induced platelet aggregation.

Author(s): 
Srivastava, K. C.
Publication Title: 
Platelets

Terminalia arjuna (TA) is a medicinal plant used as a cardiotonic in ayurveda. Besides others, scientific evidence dictates its strong hypolipidemic and antioxidant properties. However, anti-inflammatory and antiplatelet aggregatory properties of TA are not known. The present study demonstrates in vitro effects of its ethanolic bark extract (TAE) on platelet function indices. Twenty patients of angiographically proven coronary artery disease (CAD) were included in Group I and 20 age and sex-matched controls were included in Group II.

Author(s): 
Malik, Namita
Dhawan, Veena
Bahl, Ajay
Kaul, Deepak
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Stem bark gum resin extract of Boswellia serrata is traditionally used in India for its hemostatic, antiinflammatory and cardiovascular health effects and it is named as Śallakī in Ayurvedic medicine. AIM OF THE STUDY: This study was conducted to evaluate the antioxidative and antithrombotic properties of stem bark gum resin extracts of Boswellia serrata (BS). MATERIALS AND METHODS: The inhibitory activity of the BSWE and BSAE on FeCl(3) induced lipid peroxidation (in vitro) in rat liver and heart homogenates was measured spectrophotometrically.

Author(s): 
Kokkiripati, Praveen K.
Bhakshu, Lepakshi Md
Marri, Swathi
Padmasree, K.
Row, Anupama T.
Raghavendra, Agepati S.
Tetali, Sarada D.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Ayurveda, the Indian traditional system of medicine describes a unique concept "prakriti", genetically determined, categorising the population into several subgroups based on phenotypic characters like appearance, temperament and habits. The concept is claimed to be useful in predicting an individual's susceptibility to a particular disease, prognosis of that illness and selection of therapy. The present study was carried out to study if the platelet aggregatory response and its inhibition by aspirin varied in the different prakriti subtypes.

Author(s): 
Bhalerao, Supriya
Deshpande, Tejashree
Thatte, Urmila
Publication Title: 
Prostaglandins, Leukotrienes, and Essential Fatty Acids

INTRODUCTION: Many diabetics are insensitive to aspirin's platelet anti-aggregation effects. The possible modulating effects of co-administration of aspirin and fish oil in subjects with diabetes are poorly characterized. PARTICIPANTS AND METHODS: Thirty adults with type 2 diabetes mellitus were treated with aspirin 81 mg/d for 7 days, then with fish oil 4 g/day for 28 days, then the combination of fish oil and aspirin for another 7 days. RESULTS: Aspirin alone and in combination with fish oil reduced platelet aggregation in most participants.

Author(s): 
Block, Robert C.
Abdolahi, Amir
Smith, Brian
Meednu, N.
Thevenet-Morrison, Kelly
Cai, Xueya
Cui, Huadong
Mousa, Shaker
Brenna, J. Thomas
Georas, S.
Publication Title: 
Chemical & Pharmaceutical Bulletin

Two new steroidal saponins were isolated from the Chinese folk medicine called Gualou-xiebai-baijiu-tang. The structures were determined to be spirost 25(27)-ene-2beta,3beta-diol-3-O-beta-D-glucopyranosyl(1-->2)-beta-D-galactopyranoside and 26-O-beta-D-glucopyranosyl-22alpha-hydroxy-5beta-furost-25(27)-ene-1beta,3beta,6beta,26-tetraol-3-O-beta-D-galactopyranoside, respectively, based on chemical evidences and spectral analysis.

Author(s): 
He, Xiangjiu
Qiu, Feng
Shoyama, Yukihiro
Tanaka, Hiroyoki
Yao, Xinsheng
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Harpalycin 2 (HP-2) is an isoflavone isolated from the leaves of Harpalyce brasiliana Benth., a snakeroot found in northeast region of Brazil and used in folk medicine to treat snakebite. Its leaves are said to be anti-inflammatory. Secretory phospholipases A2 are important toxins found in snake venom and are structurally related to those found in inflammatory conditions in mammals, as in arthritis and atherosclerosis, and for this reason can be valuable tools for searching new anti-phospholipase A2 drugs.

Author(s): 
Ximenes, Rafael M.
Alves, Renata S.
Pereira, Ticiana P.
Araújo, Renata M.
Silveira, Edilberto R.
Rabello, Marcelo M.
Hernandes, Marcelo Z.
Soares, Veronica C. G.
Bristot, Daniel
Pires, Camila L.
Toyama, Daniela O.
Gaeta, Henrique H.
Monteiro, Helena S. A.
Toyama, Marcos H.

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