Podophyllotoxin

Publication Title: 
PloS One

Podophyllotoxin (POD) is a lignan-type toxin existing in many herbs used in folk medicine. Until now, no effective strategy is available for the management of POD intoxication. This study aims to determine the protective effects of flavonoids (quercetin and kaempferol) on POD-induced toxicity. In Vero cells, both flavonoids protected POD-induced cytotoxicity by recovering alleviating G2/M arrest, decreasing ROS generation and changes of membrane potential, and recovering microtubule structure.

Author(s): 
Li, Juan
Sun, Hua
Jin, Lu
Cao, Wei
Zhang, Jin
Guo, Chong-Yi
Ding, Ke
Luo, Cheng
Ye, Wen-Cai
Jiang, Ren-Wang
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