Polymers

Publication Title: 
Cardiovascular Toxicology

In 2011, dozens of children and pregnant women in Korea died by exposure to sterilizer for household humidifier, such as Oxy(Æ) and Cefu(Æ). Until now, however, it remains unknown how the sterilizer affect the human health to cause the acute deaths. To find its toxicity for organ, we investigated the putative toxicity of the sterilizer in the cardiovascular system. The sterilizers, polyhexamethylene guanidine phosphate (PHMG, Cefu(Æ)), and oligo-[2-(2-ethoxy)-ethoxyethyl)-guanidinium-chloride (PGH, Oxy(Æ)) were treated to human lipoproteins, macrophages, and dermal fibroblast cells.

Author(s): 
Kim, Jae-Yong
Kim, Hak Hyeon
Cho, Kyung-Hyun
Publication Title: 
Nature

In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of Sir2 (ref. 1), a member of the conserved sirtuin family of NAD(+)-dependent protein deacetylases. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53 tumour suppressor.

Author(s): 
Howitz, Konrad T.
Bitterman, Kevin J.
Cohen, Haim Y.
Lamming, Dudley W.
Lavu, Siva
Wood, Jason G.
Zipkin, Robert E.
Chung, Phuong
Kisielewski, Anne
Zhang, Li-Li
Scherer, Brandy
Sinclair, David A.
Publication Title: 
Science (New York, N.Y.)
Author(s): 
Hall, Stephen S.
Publication Title: 
Nature
Author(s): 
Finkel, Toren
Publication Title: 
Water Science and Technology: A Journal of the International Association on Water Pollution Research

A water monitoring system with a new chemical sensor for oil contamination was developed. The sensor had an organic polymer film on a quartz crystal microbalance (QCM). The organic film was a hydrocarbon polymer and had high affinities for the organic compounds of petroleum products such as gasoline, kerosene, diesel oil and fuel oil. The monitoring system as composed of a sampling part, a purging part, a humidity control part and a sensor part. The oil in contaminated river water could be detected whose threshold odour number (TON) was less than three.

Author(s): 
Ueyama, S.
Hijikata, K.
Hirotsuji, J.
Publication Title: 
Water Science and Technology: A Journal of the International Association on Water Pollution Research

A water monitoring system with a new chemical sensor for oil contamination was developed. The sensor had an organic polymer film on a quartz crystal microbalance (QCM). The organic film was a hydrocarbon polymer and had high affinities for the organic compounds of petroleum products such as gasoline, kerosene, diesel oil and fuel oil. The monitoring system as composed of a sampling part, a purging part, a humidity control part and a sensor part. The oil in contaminated river water could be detected whose threshold odour number (TON) was less than three.

Author(s): 
Ueyama, S.
Hijikata, K.
Hirotsuji, J.
Publication Title: 
FEBS letters

We recently demonstrated that 2,3,4,5,6-pentahydroxyxanthone (X5) inhibits the in vitro growth of both chloroquine-sensitive and multidrug-resistant strains of P. falciparum. To study the molecular basis of its antimalarial action, we tested X5 and selected hydroxyxanthone analogs as inhibitors of in vitro heme polymerization in a low ionic strength phosphate solution at mildly acidic pH. We found that addition of 1 Eq. of X5 resulted in complete inhibition of polymerization in this system whereas addition of up to 40 Eqs.

Author(s): 
Ignatushchenko, M. V.
Winter, R. W.
Bächinger, H. P.
Hinrichs, D. J.
Riscoe, M. K.
Publication Title: 
Chemistry & Biology

A lack of molecular understanding of the targets and mechanisms of artemisinin action has impeded the improvisation of more efficient antimalarials based on this class of endoperoxide drugs. We have synthesized a heme-artemisinin adduct designated as "hemart" to discover if it mediates the ability of artemisinin to inhibit heme polymerization. Hemart mimics heme in binding to Plasmodium falciparum histidine-rich protein II (PfHRP II) but cannot self-polymerize.

Author(s): 
Kannan, R.
Sahal, Dinkar
Chauhan, V. S.
Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

PURPOSE: A newer polymeric amphiphilic micellar system was developed in the present study for solubilization and controlled delivery of an antimalarial drug, Artemether (ART). Methoxy polyethylene glycol (MPEG) 2000 and 5000 were used as hydrophilic terminal. METHODS: The hydrophobic di-Fluorene methoxycarbonyl-l-lysine (di-FMOC-L-lysine) was linked initially to the single reactive end of MPEG, and to the two amino groups of l-lysine by consecutive peptide linkages and deprotection upto 2.5 generations (G).

Author(s): 
Bhadra, Dipankar
Bhadra, Sulekha
Jain, N. K.
Publication Title: 
Mini Reviews in Medicinal Chemistry

The biological activities and mechanisms of tea polyphenols and their polymerics have been attractive issues in cancer research. The inhibition of tea polyphenols on cancer cells decreased cell proliferation and increased apoptosis. Tremendous evidences have shown that tea polyphenols suppress tumor promotion by inhibiting enzyme activities and blocking signal transduction pathways. Specifically, the mitogen activated protein kinases (MAPK) pathways have been implicated as an important target molecular for cancer prevention and therapy.

Author(s): 
Li, W.
Mei, X.
Tu, Y. Y.

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