Polyphenols

Publication Title: 
Biological & Pharmaceutical Bulletin

The ripe fruit of Terminalia chebula RETZIUS (T. chebula RETZ) (Combretsceae), which is a native plant in India and Southeast Asia, has traditionally been used as a popular folk medicine for homeostatic, antitussive, laxative, diuretic, and cardiotonic treatments. The objective of this study was to evaluate the protective effects of an aqueous extract of fruit of T. chebula on the tert-butyl hydroperoxide (t-BHP)-induced oxidative injury observed in cultured rat primary hepatocytes and rat liver. Both treatment and pretreatment of the hepatocytes with the T.

Author(s): 
Lee, Hyun-Sun
Won, Nam Hee
Kim, Kyoung Heon
Lee, Hojoung
Jun, Woojin
Lee, Kwang-Won
Publication Title: 
Medicinal Chemistry (Shariqah (United Arab Emirates))

Ethanolic extracts of 30 Thai medicinal plants, traditionally used as alternative treatments in diabetes, were evaluated for antioxidative activity by the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method. They were evaluated in vitro for oxidative stress by thiobarbituric acid-reactive substance (TBARS) assay in pooled plasma of diabetic patients compared to without treatment of the extracts (control). The extracts were also assayed for protein glycation. The results showed that five plants had strong antioxidant activity: Phyllanthus emblica Linn.

Author(s): 
Kusirisin, W.
Srichairatanakool, S.
Lerttrakarnnon, P.
Lailerd, N.
Suttajit, M.
Jaikang, C.
Chaiyasut, C.
Publication Title: 
International Journal of Food Sciences and Nutrition

Fifteen fruits commonly used by the ethnic population in Nepal were studied for the antioxidant activity and total polyphenol content (TPC). Among them, Terminalia bellirica, Terminalia chebula, Phyllanthus emblica and Spondias pinnata were the most potent antioxidants as compared with vitamin C based on the 1,1-diphenyl-2-picryl hydrazyl radical assay. These fruits also contained high TPCs. Spondias pinnata, Pyrularia edulis, Melastoma malabathricum, Cipadema bacifera and Choerospondias axillaries fruits were evaluated for the first time.

Author(s): 
Chalise, Jaya Prakash
Acharya, Kalpana
Gurung, Nirmala
Bhusal, Ram Prasad
Gurung, Reenu
Skalko-Basnet, Natasa
Basnet, Purusotam
Publication Title: 
Phytochemistry

Thirty-four polyphenolic substances in methanol extracts of the fruits of Terminalia bellerica, Terminalia chebula and Terminalia horrida, three plants used in Egyptian folk medicine, were initially identified by HPLC-ESI-MS and quantitated by analytical HPLC after column chromatography on Sephadex LH-20. After purification by semi-preparative HPLC the compounds were identified by their mass and fragmentation patterns using ESI-MS-MS. For several compounds detailed 1H/13C NMR analysis at 600 MHz was performed.

Author(s): 
Pfundstein, Beate
El Desouky, Samy K.
Hull, William E.
Haubner, Roswitha
Erben, Gerhard
Owen, Robert W.
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

A green rapid biogenic synthesis of silver nanoparticles (Ag NPs) using Terminalia chebula (T. chebula) aqueous extract was demonstrated in this present study. The formation of silver nanoparticles was confirmed by Surface Plasmon Resonance (SPR) at 452 nm using UV-visible spectrophotometer. The reduction of silver ions to silver nanoparticles by T. chebula extract was completed within 20 min which was evidenced potentiometrically.

Author(s): 
Mohan Kumar, Kesarla
Sinha, Madhulika
Mandal, Badal Kumar
Ghosh, Asit Ranjan
Siva Kumar, Koppala
Sreedhara Reddy, Pamanji
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: The decoction of Terminalia chebula fruit is an ayurvedic remedy whose prolonged oral administration is prized as a generic intestinal and hepatic detoxifying agent. Its administration is suggested also under the perspective of a reduced risk of cancer, metabolic and cardiovascular diseases. AIM OF THE STUDY: To evaluate the phytochemical profile and the chemopreventive potential of Terminalia chebula fruit decoction prepared according to the ayurvedic decoction recipe.

Author(s): 
Pellati, Federica
Bruni, Renato
Righi, Davide
Grandini, Alessandro
Tognolini, Massimilano
Pio Prencipe, Francesco
Poli, Ferruccio
Benvenuti, Stefania
Del Rio, Daniele
Rossi, Damiano
Publication Title: 
Phytotherapy research: PTR

Eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between DNA and NF-kB, a transcription factor involved in the expression of proinflammatory genes. Cystic fibrosis (CF) cell line stimulated by TNF-? has been used as inflammatory cellular model to determinate interleukin-8 (IL-8), one of the most relevant pro-inflammatory mediator in CF regulated by the NF-kB.

Author(s): 
Guerrini, Alessandra
Mancini, Irene
Maietti, Silvia
Rossi, Damiano
Poli, Ferruccio
Sacchetti, Gianni
Gambari, Roberto
Borgatti, Monica
Publication Title: 
Biological & Pharmaceutical Bulletin

Avian pathogenic Escherichia coli (APEC) causes inflammation in multiple organs of chickens called avian colibacillosis, and results in serious economic loss to the chicken industry. Polyphenolic compounds possess a wide range of physiological activities that may contribute to their beneficial effects against inflammation-related diseases. In this study, the curative effect and mechanism of action of the polyphenolic extracts from Punica granatum L. and Terminalia chebula Retz. in chickens challenged with APEC were studied.

Author(s): 
Zhong, Xinlu
Shi, Yaran
Chen, Jiajia
Xu, Jianqing
Wang, Lei
Beier, Ross C.
Hou, Xiaolin
Liu, Fenghua
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

A green one step facile synthesis of graphene nanosheets by Terminalia chebula (T. chebula) extract mediated reduction of graphite oxide (GO) is reported in this work. This method avoids the use of harmful toxic reducing agents. The comparative results of various characterizations of GO and T. chebula reduced graphene oxide (TCG) provide a strong indication of the exclusion of oxygen containing groups from graphene oxide and successive stabilization of the formed reduced graphene oxide (RGO).

Author(s): 
Maddinedi, Sireesh Babu
Mandal, Badal Kumar
Vankayala, Raviraj
Kalluru, Poliraju
Pamanji, Sreedhara Reddy
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

Tannins are polyphenolic compounds of complex structures formed by secondary metabolism in several plants. These polyphenolic compounds have different applications, such as drugs, anti-corrosion agents, flocculants, and tanning agents. This study analyses six different type of polyphenolic extracts by Fourier transform infrared spectroscopy (FTIR) combined with multivariate analysis.

Author(s): 
Grasel, Fábio dos Santos
Ferrão, Marco Flôres
Wolf, Carlos Rodolfo

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