Polypyrimidine Tract-Binding Protein

Publication Title: 
Journal of Neuroscience Research

Amyotrophic lateral sclerosis (ALS) is caused by the progressive degeneration of motor neurons. Mutations in the Cu/Zn superoxide dismutase (SOD1) are found in approximately 20% of patients with familial ALS. Mutant SOD1 causes motor neuron death through an acquired toxic property. Although the molecular mechanism underlying this toxic gain-of-function remains unknown, evidence support the role of mutant SOD1 expression in nonneuronal cells in shaping motor neuron degeneration.

Author(s): 
Vargas, Marcelo R.
Pehar, Mariana
Díaz-Amarilla, Pablo J.
Beckman, Joseph S.
Barbeito, Luis
Publication Title: 
Journal of Lipid Research

The 3'untranslated region (UTR) of human LDL receptor (LDLR) mRNA contains three AU-rich elements (AREs) responsible for rapid mRNA turnover and mediates the stabilization induced by berberine (BBR). However, the identities of the specific RNA binding proteins involved in the regulation of LDLR mRNA stability at the steady state level or upon BBR treatment are unknown.

Author(s): 
Li, Hai
Chen, Wei
Zhou, Yue
Abidi, Parveen
Sharpe, Orr
Robinson, William H.
Kraemer, Fredric B.
Liu, Jingwen
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