Polyunsaturated Alkamides

Publication Title: 
Indian Journal of Experimental Biology

Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time.

Author(s): 
Mujumdar, A. M.
Dhuley, J. N.
Deshmukh, V. K.
Raman, P. H.
Thorat, S. L.
Naik, S. R.
Publication Title: 
Environmental Toxicology and Pharmacology

An efflux pump inhibitor, SK-20 (5-(3,4-methylenedioxyphenyle)-4 ethyl-2E,4E-pentadienoic acid piperidide), was assessed for its toxicity at three different pharmacological profiles: acute, sub-acute and general pharmacology with pharmacokinetics. In acute study, the SK-20 was found safe up to a dose of 2000 mg/kg (b.wt.); and at sub-acute, dosages of 50 and 100 mg/kg (b.wt.) were found to be safe.

Author(s): 
Rayees, Sheikh
Sharma, Rohit
Singh, Gurdarshan
Najar, Ishtiyaq Ahmad
Singh, Amarinder
Ahamad, Dastagir Basheer
Sharma, Subash Chander
Tikoo, Manoj Kumar
Gupta, Vijay Kumar
Sangwan, Payare Lal
Singh, Surjeet
Koul, Surinder
Johri, Rakesh Kamal
Publication Title: 
The Journal of Toxicological Sciences

Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety profiling.

Author(s): 
Chanda, Debabrata
Shanker, Karuna
Pal, Anirban
Luqman, Suaib
Bawankule, Dnyaneshwar Umrao
Mani, Dayanandan
Darokar, Mahendra Pandurang
Publication Title: 
TheScientificWorldJournal

In India, Ayurveda has made a major contribution to the drug discovery process with new means of identifying active compounds. Recent advancement in bioavailability enhancement of drugs by compounds of herbal origin has produced a revolutionary shift in the way of therapeutics. Thus, bibliographic investigation was carried out by analyzing classical text books and peer-reviewed papers, consulting worldwide-accepted scientific databases from last 30 years.

Author(s): 
Dudhatra, Ghanshyam B.
Mody, Shailesh K.
Awale, Madhavi M.
Patel, Hitesh B.
Modi, Chirag M.
Kumar, Avinash
Kamani, Divyesh R.
Chauhan, Bhavesh N.
Publication Title: 
Pakistan Journal of Pharmaceutical Sciences

Curcumin and piperine are proven for their potent medicinal benefits to treat various diseases and they are most commonly used combination in various Indian systems of medicine such as Ayurveda, Siddha and Unani. The objective of the present work is to develop a simultaneous estimation of curcumin and piperine by reverse phase Ultra-fast liquid chromatographic (RP-UFLC) method.

Author(s): 
Ramaswamy, Shanmugam
Kuppuswamy, Gowthamarajan
Dwarampudi, Priyanka
Kadiyala, Madhuri
Menta, Lokesh
Kannan, Elango
Publication Title: 
Journal of Ethnopharmacology

Experiments were conducted to evaluate the scientific basis of the use of the trikatu group of acrids (long pepper, black pepper and ginger) in the large number of prescriptions in Ayurveda. [3H] vasicine and [3H] sparteine were taken as test drugs. Piper longum (long pepper) increased the blood levels of vasicine by nearly 233%. Under the influence of piperine, the active principle of Piper species, sparteine blood levels increased more than 100%. The results suggest that these acrids have the capacity to increase the bioavailability of certain drugs.

Author(s): 
Atal, C. K.
Zutshi, U.
Rao, P. G.
Publication Title: 
The Journal of Toxicological Sciences

Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety profiling.

Author(s): 
Chanda, Debabrata
Shanker, Karuna
Pal, Anirban
Luqman, Suaib
Bawankule, Dnyaneshwar Umrao
Mani, Dayanandan
Darokar, Mahendra Pandurang
Publication Title: 
TheScientificWorldJournal

In India, Ayurveda has made a major contribution to the drug discovery process with new means of identifying active compounds. Recent advancement in bioavailability enhancement of drugs by compounds of herbal origin has produced a revolutionary shift in the way of therapeutics. Thus, bibliographic investigation was carried out by analyzing classical text books and peer-reviewed papers, consulting worldwide-accepted scientific databases from last 30 years.

Author(s): 
Dudhatra, Ghanshyam B.
Mody, Shailesh K.
Awale, Madhavi M.
Patel, Hitesh B.
Modi, Chirag M.
Kumar, Avinash
Kamani, Divyesh R.
Chauhan, Bhavesh N.
Publication Title: 
Pakistan Journal of Pharmaceutical Sciences

Curcumin and piperine are proven for their potent medicinal benefits to treat various diseases and they are most commonly used combination in various Indian systems of medicine such as Ayurveda, Siddha and Unani. The objective of the present work is to develop a simultaneous estimation of curcumin and piperine by reverse phase Ultra-fast liquid chromatographic (RP-UFLC) method.

Author(s): 
Ramaswamy, Shanmugam
Kuppuswamy, Gowthamarajan
Dwarampudi, Priyanka
Kadiyala, Madhuri
Menta, Lokesh
Kannan, Elango
Publication Title: 
Journal of AOAC International

Churnas are an important group of formulations used by traditional physicians to treat various types of diseases. The principle of using a churna is based on the fact that the therapeutic value of most substances greatly increases when they are reduced to a very fine state of subdivision. Catpusphadhya churna, as per the Ayurvedic system of Indian medicine, is used for acute rheumatoid arthritis. In the present study, an attempt was made to develop an HPTLC method for the quantitative determination of piperine, embeline, and carvone in a laboratory-prepared formulation.

Author(s): 
Jain, Kajal L.
Patel, Rakesh K.
Patel, Hardik P.

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