Potassium Chloride

Publication Title: 
Neurotoxicity Research

?-Synuclein is the key aggregating protein in Parkinson's disease (PD), which is characterized by cytoplasmic protein inclusion bodies, termed Lewy bodies, thought to increase longevity of the host neuron by sequestering toxic soluble ?-synuclein oligomers. Previous post-mortem studies have shown relative sparing of neurons in PD that are positive for the Ca(2+) buffering protein, calbindin, and recent cell culture and in vitro studies have shown that ?-synuclein aggregation can be induced by Ca(2+).

Author(s): 
Follett, Jordan
Darlow, Bonnie
Wong, Mathew B.
Goodwin, Jacob
Pountney, Dean L.
Publication Title: 
Neuropharmacology

Over the last several years proteins involved in base excision repair (BER) have been implicated in active DNA demethylation. We review the literature supporting BER as a means of active DNA demethylation, and explain how the various components function and cooperate to remove the potentially most enduring means of epigenetic gene regulation. Recent evidence indicates that the same pathways implicated during periods of widespread DNA demethylation, such as the erasure of methyl marks in the paternal pronucleus soon after fertilization, are operational in post-mitotic neurons.

Author(s): 
Gavin, David P.
Chase, Kayla A.
Sharma, Rajiv P.
Publication Title: 
Behavioral Biology
Author(s): 
Teschke, E. J.
Maser, J. D.
Gallup, G. C.
Publication Title: 
BMC infectious diseases

BACKGROUND: Diarrhoea accounts for 20% of all paediatric deaths in India. Despite WHO recommendations and IAP (Indian Academy of Paediatrics) and Government of India treatment guidelines, few children suffering from acute diarrhoea in India receive low osmolarity oral rehydration solution (ORS) and zinc from health care providers. The aim of this study was to analyse practitioners' prescriptions for acute diarrhoea for adherence to treatment guidelines and further to determine the factors affecting prescribing for diarrhoea in Ujjain, India.

Author(s): 
Pathak, Deepali
Pathak, Ashish
Marrone, Gaetano
Diwan, Vishal
Lundborg, Cecilia Stålsby
Publication Title: 
BMC infectious diseases

BACKGROUND: Diarrhoea accounts for 20% of all paediatric deaths in India. Despite WHO recommendations and IAP (Indian Academy of Paediatrics) and Government of India treatment guidelines, few children suffering from acute diarrhoea in India receive low osmolarity oral rehydration solution (ORS) and zinc from health care providers. The aim of this study was to analyse practitioners' prescriptions for acute diarrhoea for adherence to treatment guidelines and further to determine the factors affecting prescribing for diarrhoea in Ujjain, India.

Author(s): 
Pathak, Deepali
Pathak, Ashish
Marrone, Gaetano
Diwan, Vishal
Lundborg, Cecilia Stålsby
Publication Title: 
BMC infectious diseases

BACKGROUND: Diarrhoea accounts for 20% of all paediatric deaths in India. Despite WHO recommendations and IAP (Indian Academy of Paediatrics) and Government of India treatment guidelines, few children suffering from acute diarrhoea in India receive low osmolarity oral rehydration solution (ORS) and zinc from health care providers. The aim of this study was to analyse practitioners' prescriptions for acute diarrhoea for adherence to treatment guidelines and further to determine the factors affecting prescribing for diarrhoea in Ujjain, India.

Author(s): 
Pathak, Deepali
Pathak, Ashish
Marrone, Gaetano
Diwan, Vishal
Lundborg, Cecilia Stålsby
Publication Title: 
Nature Neuroscience

In traditional folk medicine, Xanthoxylum plants are referred to as 'toothache trees' because their anesthetic or counter-irritant properties render them useful in the treatment of pain. Psychophysical studies have identified hydroxy-alpha-sanshool as the compound most responsible for the unique tingling and buzzing sensations produced by Szechuan peppercorns or other Xanthoxylum preparations. Although it is generally agreed that sanshool elicits its effects by activating somatosensory neurons, the underlying cellular and molecular mechanisms remain a matter of debate.

Author(s): 
Bautista, Diana M.
Sigal, Yaron M.
Milstein, Aaron D.
Garrison, Jennifer L.
Zorn, Julie A.
Tsuruda, Pamela R.
Nicoll, Roger A.
Julius, David
Publication Title: 
General Physiology and Biophysics

In this paper we present the results of studying the effects of the essential oil of Calamintha glandulosa Silic (EOCG) on the isolated rat ileum. C. glandulosa Silic has been used in folk medicine as an antispasmodic. EOCG (0.003-1 mg/ml) inhibited spontaneous contraction of the ileum (EC50 of 210.48 +/- 9.12 microg/ml). The calcium channel blocking activity was confirmed by inhibition of K(+) (80 mmol/l) induced contractions with EOCG (EC50 of 88.81 +/- 6.01 microg/ml).

Author(s): 
Brankovic, Suzana V.
Kitic, Dusanka V.
Radenkovic, Mirjana M.
Veljkovic, Slavimir M.
Golubovic, Tatjana D.
Publication Title: 
Circulation Journal: Official Journal of the Japanese Circulation Society

BACKGROUND: Common variations in the gene with no-lysine kinase 1 (WNK1) are associated with hypertension, but because of gene-environment interaction, it is difficult to fully identify the genetic contribution of WNK1 gene polymorphism to blood pressure (BP) variability. The aim of this study was to identify the effect of common WNK1 variants on the shift of BP during strict dietary interventions of salt or potassium intake.

Author(s): 
Liu, Fuqiang
Zheng, Shuhui
Mu, Jianjun
Chu, Chao
Wang, Lan
Wang, Yang
Xiao, Hongyu
Wang, Dan
Cao, Yu
Ren, Keyu
Liu, Enqi
Yuan, Zuyi
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Dysmenorrhea is directly related to elevated PGF(2alpha) levels. It is treated with nonsteroid antiinflammatory drugs (NSAIDs) in Western medicine. Since NSAIDs produce many side effects, Chinese medicinal therapy is considered as a feasible alternative medicine. Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) has been used as a traditional Chinese medicine for treating dysmenorrhea. However, the relationship between smooth muscle contraction and adlay extracts remains veiled.

Author(s): 
Hsia, Shih-Min
Kuo, Yueh-Hsiung
Chiang, Wenchang
Wang, Paulus S.

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