PPAR gamma

Publication Title: 
PloS One

BACKGROUND: Treatments for inflammatory bowel disease (IBD) are modestly effective and associated with side effects from prolonged use. As there is no known cure for IBD, alternative therapeutic options are needed. Peroxisome proliferator-activated receptor-gamma (PPARγ) has been identified as a potential target for novel therapeutics against IBD. For this project, compounds were screened to identify naturally occurring PPARγ agonists as a means to identify novel anti-inflammatory therapeutics for experimental assessment of efficacy.

Author(s): 
Lewis, Stephanie N.
Brannan, Lera
Guri, Amir J.
Lu, Pinyi
Hontecillas, Raquel
Bassaganya-Riera, Josep
Bevan, David R.
Publication Title: 
PloS One

BACKGROUND: Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the eukaryotic lanthionine synthetase component C-Like protein family involved in signal transduction and insulin sensitization. Recently, LANCL2 is a target for the binding and signaling of abscisic acid (ABA), a plant hormone with anti-diabetic and anti-inflammatory effects. METHODOLOGY/PRINCIPAL FINDINGS: The goal of this study was to determine the role of LANCL2 as a potential therapeutic target for developing novel drugs and nutraceuticals against inflammatory diseases.

Author(s): 
Lu, Pinyi
Hontecillas, Raquel
Horne, William T.
Carbo, Adria
Viladomiu, Monica
Pedragosa, Mireia
Bevan, David R.
Lewis, Stephanie N.
Bassaganya-Riera, Josep
Publication Title: 
Neurochemical Research

Microglial activation participates in the pathogenesis of various neuroinflammatory and neurodegenerative diseases. However, mechanisms by which microglial activation could be controlled are poorly understood. Peroxisome proliferator-activated receptors (PPAR) are transcription factors belonging to the nuclear receptor super family with diverse effect. This study underlines the importance of PPARβ/δ in mediating the anti-inflammatory effect of gemfibrozil, an FDA-approved lipid-lowering drug, in primary human microglia.

Author(s): 
Jana, Malabendu
Pahan, Kalipada
Publication Title: 
The Journal of Nutritional Biochemistry

The bone undergoes continuous remodeling of osteoblastic bone formation and osteoclastic bone resorption to maintain proper bone mass. It is also reported that bone marrow adiposity has a reciprocal role in osteoblasts due to their same origin from mesenchymal stem cells. In addition, one of the key mediators of adipogenesis, peroxisome-proliferator activated receptor-γ (PPARγ), plays a significant role in osteoblastogenesis in bone marrow mesenchymal stem cells. One dietary component that is known to have significant impact on adiposity and bone mass is conjugated linoleic acid (CLA).

Author(s): 
Kim, Jonggun
Park, Yooheon
Lee, Seong-Ho
Park, Yeonhwa
Publication Title: 
The Journal of Biological Chemistry

An increase in CNS remyelination and a decrease in CNS inflammation are important steps to halt the progression of multiple sclerosis. Earlier studies have shown that gemfibrozil, a lipid-lowering drug, has anti-inflammatory properties.

Author(s): 
Jana, Malabendu
Mondal, Susanta
Gonzalez, Frank J.
Pahan, Kalipada
Publication Title: 
Current Opinion in Rheumatology

PURPOSE OF REVIEW: Racial disparities appear to exist in the susceptibility and severity of systemic sclerosis (SSc, scleroderma) and are responsible for a greater health burden in blacks as compared with whites. Disparities in socioeconomic status and access to healthcare do not sufficiently explain the observed differences in prevalence and mortality. It is important to determine whether there might be a biologic basis for the racial disparities observed in SSc.

Author(s): 
Silver, Richard M.
Bogatkevich, Galina
Tourkina, Elena
Nietert, Paul J.
Hoffman, Stanley
Publication Title: 
The Journal of Nutritional Biochemistry

The anti-inflammatory phytohormone abscisic acid (ABA) modulates immune and inflammatory responses in mouse models of colitis and obesity. ABA has been identified as a ligand of lanthionine synthetase C-like 2, a novel therapeutic target upstream of the peroxisome proliferator-activated receptor γ (PPARγ) pathway. The goal of this study was to investigate the immune modulatory mechanisms underlying the anti-inflammatory efficacy of ABA against influenza-associated pulmonary inflammation.

Author(s): 
Hontecillas, Raquel
Roberts, Paul C.
Carbo, Adria
Vives, Cristina
Horne, William T.
Genis, Sandra
Velayudhan, Binu
Bassaganya-Riera, Josep
Publication Title: 
The Journal of Biological Chemistry

12/15-Lipoxygenases (LOXs) in monocytes and macrophages generate novel phospholipid-esterified eicosanoids. Here, we report the generation of two additional families of related lipids comprising 15-ketoeicosatetraenoic acid (KETE) attached to four phosphatidylethanolamines (PEs). The lipids are generated basally by 15-LOX in IL-4-stimulated monocytes, are elevated on calcium mobilization, and are detected at increased levels in bronchoalveolar lavage fluid from cystic fibrosis patients (3.6 ng/ml of lavage).

Author(s): 
Hammond, Victoria J.
Morgan, Alwena H.
Lauder, Sarah
Thomas, Christopher P.
Brown, Sarah
Freeman, Bruce A.
Lloyd, Clare M.
Davies, Jane
Bush, Andrew
Levonen, Anna-Liisa
Kansanen, Emilia
Villacorta, Luis
Chen, Y. Eugene
Porter, Ned
Garcia-Diaz, Yoel M.
Schopfer, Francisco J.
O'Donnell, Valerie B.
Publication Title: 
PloS One

Clostridium difficile is an anaerobic bacterium that has re-emerged as a facultative pathogen and can cause nosocomial diarrhea, colitis or even death. Peroxisome proliferator-activated receptor (PPAR) γ has been implicated in the prevention of inflammation in autoimmune and infectious diseases; however, its role in the immunoregulatory mechanisms modulating host responses to C. difficile and its toxins remains largely unknown. To characterize the role of PPARγ in C. difficile-associated disease (CDAD), immunity and gut pathology, we used a mouse model of C.

Author(s): 
Viladomiu, Monica
Hontecillas, Raquel
Pedragosa, Mireia
Carbo, Adria
Hoops, Stefan
Michalak, Pawel
Michalak, Katarzyna
Guerrant, Richard L.
Roche, James K.
Warren, Cirle A.
Bassaganya-Riera, Josep
Publication Title: 
PloS One

BACKGROUND: There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect the secretion of gastric hormones that relate to energy homeostasis. H. pylori strains that carry the cag pathogenicity island (PAI) interact more intimately with gastric epithelial cells and trigger more extensive host responses than cag(-) strains. We hypothesized that gastric colonization with H. pylori strains differing in cag PAI status exert distinct effects on metabolic and inflammatory phenotypes.

Author(s): 
Bassaganya-Riera, Josep
Dominguez-Bello, Maria Gloria
Kronsteiner, Barbara
Carbo, Adria
Lu, Pinyi
Viladomiu, Monica
Pedragosa, Mireia
Zhang, Xiaoying
Sobral, Bruno W.
Mane, Shrinivasrao P.
Mohapatra, Saroj K.
Horne, William T.
Guri, Amir J.
Groeschl, Michael
Lopez-Velasco, Gabriela
Hontecillas, Raquel

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